Research Interest: Business Economics, Knowledge Management, Cost Benefit Analysis Method – application in company and in medical device market development, Healthcare, efectivness of medical equipment development. 

Weihua Qiao, MD, PhD, is a Cardiovascular Surgeon and Associate Professor of Surgery at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Dr. Qiao earned his medical degree from Chongqing Medical University in 2011. He obtained his PhD in the Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology with Dr. Nianguo Dong in 2016. His clinical interests include complex congenital cardiac surgery, minimally invasive cardiac surgery, and cardiac transplantation. Dr. Qiao serves as Principal Investigator on grants funded by National Key Research and Development Plan of China, National Natural Science Foundation of China, and other national/funding resources. His research is focused on biomedical materials and cardiovascular tissue engineering. Dr. Qiao has published more than 40 peer-review research papers including Circulation, European Heart Journal, Advanced Functional Materials and Acta Biomaterialia, and filed more than 10 patents. He has served as an editorial member and peer reviewer for several scientific journals in cardiovascular research and biomaterials. He has also served as mentor or advisor for a number of postdoctoral fellows, medical students, graduate and undergraduate students.

Research Interest: Biomedical materials and cardiovascular tissue engineering.

Publication List:

1. Ziwen Cai^#, Miaomiao Zhu^#, Li Xu^#, Yue Wang, Yin Xu, Wai Yen Yim, Hong Cao, Ruikang Guo, Xiang Qiu, Ximiao He, Jiawei Shi, Weihua Qiao* and Nianguo Dong*. Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells. Circulation. 2024. DOI: 10.1161/CIRCULATIONAHA.123.065143. (Co-corresponding author).
2. Shijie Wang, Weihua Qiao*, Nianguo Dong*. Residual shunt and microthrombosis associated with new-onset migraine after transcatheter atrial septal defect closure. European Heart Journal. 2023, 44(43): 4605-4605. (Co-corresponding author).
3. Ying Zhou^#, Ge Yan^#, Shuyu Wen, Wai Yen Yim, Zihao Wang, Xing Chen, Yin Xu, Xue Chen, Hong Cao, Peng Bai, Fei Li, Jiawei Shi, Jianglin Wang, Weihua Qiao*, Nianguo Dong*. Nitric Oxide Generation and Endothelial Progenitor Cells Recruitment for Improving Hemocompatibility and Accelerating Endothelialization of Tissue Engineering Heart Valve. Advanced Functional Materials. 2023, 33(9): 2211267. (Co-corresponding author).
4. Hong Cao^#, Qian Zhou^#, Chungeng Liu, Yecen Zhang, Minghui Xie, Weihua Qiao*, Nianguo Dong*. Substrate stiffness regulates differentiation of induced pluripotent stem cells into heart valve endothelial cells. Acta Biomaterialia. 2022, 143: 115-126. (Co-corresponding author).
5. Xing Chen, Yunlong Wu, Rui Li, Chenghao Li, Li Xu*, Weihua Qiao*, Nianguo Dong*. Galactose-modified nanoparticles for delivery of microRNA to mitigate the progress of abdominal aortic aneurysms via regulating macrophage polarization. Nanomedicine: Nanotechnology, Biology and Medicine. 2022, 44: 102564. (Co-corresponding author).
6. Shuangshuang Zhu^#, Yanting Zhang^#, Weihua Qiao^#, Yixuan Wang, Yuji Xie, Xin Zhang, Chun Wu, Guohua Wan4, Yuman Li, Nianguo Dong*, Mingxing Xie*, Li Zhang*. Incremental value of preoperative right ventricular function in predicting moderate to severe acute kidney injury after heart transplantation. Frontiers in cardiovascular medicine. 2022, 9: 931517. (Co-first author).
7. Xing Chen^#, Wei-hua Qiao^#, Hong Cao^#, Jia-wei Shi, Xin-ling Du*, Nian-guo Dong*. Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage. Current Medical Science. 2022, 42(3): 555-560. (Co-first author).
8. Shuyu Wen^#, Ying Zhou^#, Wai Yen Yim, Shijie Wang, Li Xu, Jiawei Shi, Weihua Qiao*, Nianguo Dong*. Mechanisms and Drug Therapies of Bioprosthetic Heart Valve Calcification. Frontiers in Pharmacology. 2022, 13: 909801. (Co-corresponding author).
9. Ge Yan, Yuqi Liu, Minghui Xie, Jiawei Shi, Weihua Qiao*, Nianguo Dong*. Experimental and computational models for tissue-engineered heart valves: a narrative review. Biomaterials Translational. 2021; 2(4): 361–375. (Co-corresponding author).
10. Baocheng Zhang^#, Yuan Xu^#, Sitian Ma, Linfeng Wang, Changjun Liu, Weilin Xu, Jiawei Shi, Weihua Qiao*, Hongjun Yang*. Small-diameter polyurethane vascular graft with high strength and excellent compliance            . Journal of the Mechanical Behavior of Biomedical Materials. 2021, 121: 104614. (Co-corresponding author).
11. Changjun Liu^#, Weihua Qiao^#, Chaorong Wang, Han Wang, Yingshan Zhou, Shaojin Gua, Weilin Xu, Yan Zhuang, Jiawei Shi*, Hongjun Yang*. Effect of poly (lactic acid) porous membrane prepared via phase inversion induced by water droplets on 3T3 cell behavior. International Journal of Biological Macromolecules. 2021, 183: 2205-2214. (Co-first author).
12. Chungeng Liu^#, Weihua Qiao^#, Hong Cao, Jinchi Dai, Fei Li, Jiawei Shi* and Nianguo Dong*. A riboflavin–ultraviolet light A-crosslinked decellularized heart valve for improved biomechanical properties, stability, and biocompatibility. Biomaterials Science. 2020, 8(9): 2549-2563. (Co-first author).
13. Han Wang^#, Weihua Qiao^#, Sitian Ma, Linfeng Wang, Changjun Liu, Yingshan Zhou, Shaojin Gu, Weilin Xu, Jiawei Shi*, Hongjun Yang*. Effect of temperature on the thermal property and crystallization behavior of poly (lactic acid) porous membrane prepared via phase separation induced by water microdroplets. International Journal of Biological Macromolecules. 2020, 147: 1185-1192. (Co-first author).
14. Shuyu Wen^#, Weihua Qiao^#, Yuan Zhang, and Nianguo Dong*. Development and trend in the field of valvular heart disease in China: an analysis based on the National Natural Science Foundation of China. Annals of Translational Medicine, 2020, 8(7): 449. (Co-first author).
15. Jinchi Dai^#, Weihua Qiao^#, Jiawei Shi, Chungen Liu, Xingjian Hu, Nianguo Dong. Modifying Decellularized Aortic Valve Scaffolds with Stromal Cell-derived Factor-1α Loaded Proteolytically Degradable Hydrogel for Recellularization and Remodeling. Acta Biomaterialia, 2019, 88: 280-292. (Co-first author).
16. Wei-hua Qiao^#, Peng Liu, Dan Hu, Mahmoud Al Shirbini, Xian-ming Zhou, Nian-guo Dong*. Sequential hydrophile and lipophile solubilization as an efficient method for decellularization of porcine aortic valve: structure, mechanical property and biocompatibility study. Journal of Tissue Engineering and Regenerative Medicine. 2018, 12(2): e828-e840.
17. Geng Li^#, Weihua Qiao^#, Wenjing Zhang, Fei Li, Jiawei Shi, Nianguo Dong*. The shift of macrophages toward M1 phenotype promotes aortic valvular calcification. Journal of Thoracic and Cardiovascular Surgery. 2017, 153(6): 1318-1327. e1. (Co-first author).
18. Peng Liu^#, Wei-Hua Qiao^#, Fu-Qiang Sun, Xin-Long Ruan, Mahmoud Al Shirbini, Dan Hu, Si Chen, Nian-Guo Dong*. Should a Mechanical or Biological Prosthesis Be Used for a Tricuspid Valve Replacement? A Meta-Analysis. Journal of Cardiac Surgery. 2016, 31(5): 294-302. (Co-first author).
19. Weihua Qiao^#, Nianguo Dong, Peng Liu, Dan Hu, Fayuan Liu, Jiawei Shi. Perfusion decellularization method for the fabrication of decellularized porcine aortic valve scaffold. Chinese Journal of Experimental Surgery. 2016, 33(4): 1023-1025. (Chinese journal)
20. Weihua Qiao^#, Peng Liu, Jiawei Shi, Yin Wang, Nianguo Dong. Changes of Left Ventricular Morphology and Contractile Function after Mitral Valve Replacement of Patients with Mitral Stenosis and Small Left Ventricle: A Meta-analysis. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery. 2016, 23(6): 589-594. (Chinese journal)
21. Weihua Qiao^#, Nianguo Dong, Jiawei Shi. Meta-Analysis of the Association between TBX1 Gene Mutation and Conotruncal Defects. Chinese Journal of Practical Pediatrics. 2014, 29(9): 677-680. (Chinese journal)
22. Weihua Qiao^#, Nianguo Dong. Is there an age limit for the use of biologic valve? Journal of Clinical Cardiology. 2014, 30(9): 745-748. (Chinese journal)
23. Shuyu Wen, Ying Zhou, Weihua Qiao, Yixuan Wang, Jing Zhang, Nianguo Dong. Infant heart transplantation with extremely oversized donor heart: is the donor–recipient size matching too conservative?. ESC Heart Failure. 2023, 10(2): 1431-1434.
24. Yuanming Li, Ying Zhou, Weihua Qiao, Jiawei Shi, Xuefeng Qiu*, Nianguo Dong*. Application of decellularized vascular matrix in small-diameter vascular grafts. Frontiers in Bioengineering and Biotechnology. 2023, 10: 1081233.
25. Yuqi Zheng, Shuyu Wen, Shijiu Jiang, Shaolin He, Weihua Qiao, Yi Liu, Wenling Yang, Jin Zhou, Boyuan Wang, Dazhu Li, Jibin Lin. CircRNA/lncRNA-miRNA-mRNA network and gene landscape in calcific aortic valve disease. BMC genomics. 2023, 24(1): 419.
26. Yuqi Chen, Zongtao Liu, Fayuan Liu, Li Xu, Geng Li, Weihua Qiao, Yixuan Wang, Nianguo Dong. T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation. Clinical Immunology. 2023, 252: 109647.
27. Xue Chen, Nianguo Dong, Xu Xu, Ying Zhou, Jiawei Shi, Weihua Qiao, Hao Hong. Re-endothelialization of Decellularized Scaffolds With Endothelial Progenitor Cell Capturing Aptamer: A New Strategy for Tissue-Engineered Heart Valve. ASAIO Journal. 2023, 69(9): 885-893.
28. Shuyu Wen, Weihua Qiao, Nianguo Dong. Current status and progress of aortic valve surgery treatment. Journal of Clinical Cardiology. 2023, 39(6): 417-424. (Chinese journal)
29. Peng Bai, Gangcheng Kong, Weihua Qiao, Yu Song, Yixuan Wang, Jiawei Shi, Nan Zhang, Chungeng Liu, Chong Chu, Tixiusi Xiong, Ying Zhou, Cuifen Lu, Lin Wang, Nianguo Dong. A Novel Method to Improve the Physical Property and Biocompatibility of Decellularized Heart Valve Scaffold with Sericin and Polydopamine. Journal of Bionic Engineering. 2022, 19(4): 1109-1123.
30. Chanchan Song, Linli Wang, Qingyang Li, Baoyi Liao, Weihua Qiao, Qiang Li, Nianguo Dong, Liangping Li. Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells. Stem cell research & therapy. 2022, 13(1): 1-17.
31. Ming-Hui Xie, Wei-Hua Qiao, Hong Cao, Jia-Wei Shi, Nian-Guo Dong. Progress in the Role of Mechanical Stimulus in Cardiac Development. Acta Academiae Medicinae Sinicae. 2022, 44(1): 164-172. (Chinese journal)
32. Peng Liu, Dong-Sheng Xia, Wei-Hua Qiao, Dan Hu, Adnan Ahmed, Nian-Guo Dong, Si Chen. Which is the best prosthesis in an isolated or combined tricuspid valve replacement?. European Journal of Cardio-Thoracic Surgery. 2021, 59(1): 170-179.
33. Shuangshuang Zhu, Yuji Xie, Weihua Qiao, Fangyan Tian, Wei Sun, Yixuan Wang, Chun Wu, He Li, Luyang Yi, Yi Zhong, Nianguo Dong, Yuman Li, Mingxing Xie, Li Zhang. Impaired left atrial function in clinically well heart transplant patients. The International Journal of Cardiovascular Imaging. 2021, 37: 1937-1945.
34. LinXi Cheng, MingHui Xie, WeiHua Qiao, Yu Song, YanYong Zhang, YingChao Geng, WeiLin Xu, Lin Wang, Zheng Wang, Kai Huang, NianGuo Dong, YuHua Sun. Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells. Communications Biology. 2021, 4(1): 1039.
35. Qin WANG, Yuzhi QIU, Weihua QIAO, Nianguo DONG, Yajiang YANG. Gelation Systems and Mechanisms of Chondroitin Sulfate-Based Injectable Hydrogels. Journal of Functional Polymers. 2021, 34(3): 243-259. (Chinese journal)
36. Shuyu Wen, Weihua Qiao, Nianguo Dong. Applications of enhanced recovery after surgery in cardiovascular surgery. Journal of Clinical Cardiology. 2021, 37(9): 787-790. (Chinese journal)
37. Ge YAN, Wei-hua QIAO, Hong CAO, Jia-wei SHI, Nian-guo DONG. Application of surface modification of polydopamine in tissue engineering. China Biotechnology. 2021, 40(12): 75-81. (Chinese journal)
38. Shuangshuang Zhu, Wei Sun, Weihua Qiao, Meng Li, Yuman Li, Bo Liang, Jing Wang, Nianguo Dong, Li Zhang, Mingxing Xie. Real time three-dimensional echocardiographic quantification of left atrial volume in orthotopic heart transplant recipients: Comparisons with cardiac magnetic resonance imaging. Echocardiography. 2020, 37(8): 1243-1250.
39. Peng Bai, Weihua Qiao, Nan Zhang, Chungen Liu, Jiawei Shi, Nianguo Dong. Advances in research on recellularization of tissue engineered heart valves based on decellularized matrix. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong. 2018, 47(2): 244-250. (Chinese journal)
40. Huadong Li, Jiawei Shi, Weihua Qiao, Nianguo Dong, Gangjian Qin. Abstract 43: SIRT1 Enhances Oxidized Low-density Lipoprotein Induced Autophagy in Human Valve Interstitial Cells. Circulation Research. 2016, 119(suppl_1).
41. Qi Liu^#, Wei-Hua Qiao, Fei-fei Li, Peng Deng, and Zhi-wei Hu*. The Role of Interleukin-13 in Patients with Rheumatic Valvular Fibrosis: A Clinical and Histological Study. Journal of Heart Valve Disease. 2015, 24(4):496-501.

Research Interest: Military toxicology; Acetylcholinesterase reactivators as treatment of nerve agent and pesticide intoxications; Acetylcholinesterase inhibitors in Alzheimer´s disease and Myasthenia Gravis treatment; Synthesis of the detergents as disinfectants, decontamination means and environment for micellar catalysis; Drug design and Development; Chemical warfare agents; Biological warfare agents; Pharmaceutical Industry; Project Management; Scientific Management; Technology Transfer; Commercialization; Fund Raising; Cloud computing; Parallel computing; medical devices development; toxins. 

Research Interest: Development of new lanthanide complexes for MRI and optical imaging: synthesis, purification (HPLC, flash chromatography) and physicochemical characterization (NMR spectroscopy, mass spectrometry, luminescence, UV-visible, FTIR).  

Research Interest: Surgical planning and simulation in esthetical facial surgeryTelemedicine o Biomedical engineering 

Research Interest: Synthesis and characterization of inorganic and hybrid organic-inorganic nanomaterials, calcium phosphates, biomaterials, drug delivery, biomineralization and nanomedicine.

Research Interest: Design, fabrication, and optical properties of nanomaterials,- Biomedical applications (biosensing, bioimaging, therapy) of nanomaterials ,- Surface-enhanced Raman scattering and related biomedical applications

Research Interest: His current research interests include non-linear analysis of biomedical time series, specially the analysis of electroencephalographic and magnetoencephalographic recordings to help physicians in the diagnosis of brain disorders

Biography:

My research focuses on establishing the clinical applicability of two new diagnostic parameters (to detect coronary artery disease) using a set of bench-top experiments, computational analysis, pre-clinical and clinical trials in our research group. These proposed diagnostic parameters based on fluid dynamic principles, pressure drop coefficient and lesion flow coefficient, have the potential to make a real paradigm shift in clinical decision making related to cardiovascular intervention. As part of my research involving pre-clinical and clinical trials I had collaborated with clinicians and scientists at College of Medicine, University of Cincinnati and at Cincinnati Children's Hospital and Medical Center. Preliminary results from these studies have concluded the clinical applicability of these parameters to distinguish between stenoses of various severity.
More recently, at Weill Cornell Medical College, I am working on using 3D printing, machine learning and computational fluid dynamics to predict and prevent coronary artery disease from non-invasive CCTA imaging data.

Research Interest: 3D printing, Computational fluid dynamics, clinical radiology, non-invasive CCTA scanning, machine learning, interventional cardiology, applied mathematics, bio-heat transfer

List of Publications:

1. Al'Aref SJ, Anchouche K, Singh G, Slomka PJ, Kolli KK, Kumar A, Pandey M, Maliakal G, van Rosendael AR, Beecy AN, Berman DS, Leipsic J, Nieman K, Andreini D, Pontone G, Schoepf UJ, Shaw LJ, Chang HJ, Narula J, Bax JJ, Guan Y, Min JK. Clinical applications of machine learning in cardiovascular disease and its relevance to cardiac imaging. Eur Heart J. 2018. Epub 2018/07/31. doi: 10.1093/eurheartj/ehy404. PubMed PMID: 30060039. Available from: https://www.ncbi.nlm.nih.gov/pubmed/30060039.

2. Kolli KK, Min JK. Image-based computational fluid dynamic analysis for surgical planning of sequential grafts in coronary artery bypass grafting. Accepted as Contributed full paper for publication in Conference Proceedings for IEEE Engineering in Medicine and Biology Society Conference. 2018. [Accepted]

3. van Rosendael AR, Maliakal G, Kolli KK, Beecy A, Al'Aref SJ, Dwivedi A, Singh G, Panday M, Kumar A, Ma X, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Gransar H, Lu Y, Jones EC, Pena JM, Lin FY, Min JK. Maximization of the usage of coronary CTA derived plaque information using a machine learning based algorithm to improve risk stratification; insights from the CONFIRM registry. J Cardiovasc Comput Tomogr. 2018;12(3):204-9. Epub 2018/05/14. doi: 10.1016/j.jcct.2018.04.011. PubMed PMID: 29753765. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29753765.

4. Singh G, Al'Aref SJ, Van Assen M, Kim TS, van Rosendael A, Kolli KK, Dwivedi A, Maliakal G, Pandey M, Wang J, Do V, Gummalla M, De Cecco CN, Min JK. Machine learning in cardiac CT: Basic concepts and contemporary data. J Cardiovasc Comput Tomogr. 2018; 12(3):192-201. Epub 2018/05/15. doi: 10.1016/j.jcct.2018.04.010. PubMed PMID: 29754806. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29754806.

5. Beecy AN, Chang Q, Anchouche K, Baskaran L, Elmore K, Kolli KK, Wang H, Al'Aref S, Pena JM, Knight-Greenfield A, Patel P, Sun P, Zhang T, Kamel H, Gupta A, Min JK. A Novel Deep Learning Approach for Automated Diagnosis of Acute Ischemic Infarction on Computed Tomography. JACC Cardiovascular imaging. 2018. Epub 2018/05/21. doi: 10.1016/j.jcmg.2018.03.012. PubMed PMID: 29778866. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29778866.

6. Peelukhana SV, Banerjee R, van de Hoef TP, Kolli KK, Effat M, Helmy T, Leesar M, Kerr H, Piek JJ, Succop P, Back L, Arif I. Evaluation of lesion flow coefficient for the detection of coronary artery disease in patient groups from two academic medical centers. Cardiovascular Revascularization
Kranthi Kolli 6 10/05/2018Medicine. 2018;19(3 Pt B):348-54. Epub 2017/10/19. doi: 10.1016/j.carrev.2017.08.018. PubMed PMID: 29037762. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29037762.

7. Han D, Starikov A, Xiong G, Hartaigh B, Granser H, Kolli KK, Lee J, Rizvi A, Baskaran L, Schulman-Marcus J, Lin FY, Min JK. Relationship between endothelial wall shear stress and high-risk atherosclerotic plaque characteristic for identification of coronary lesions that cause ischemia: A direct comparison to fractional flow reserve. Journal of the American Heart Association. 2016; 5(12). doi: 10.1161/JAHA.116.004186. PubmMed PMID: 27993831. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27993831

8. Kolli KK, Min JK, Ha S, Soohoo H, Xiong G. Effect of Varying Hemodynamic and Vascular Conditions on Fractional Flow Reserve: An In Vitro Study. Journal of the American Heart Association. 2016;5(7). doi: 10.1161/JAHA.116.003634. PubMed PMID: 27364988. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27364988.

9. Kolli KK, van de Hoef TP, Effat MA, Banerjee RK, Peelukhana SV, Succop P, Leesar MA, Imran A, Piek JJ, Helmy TA. Diagnostic cutoff for pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve: A patient-level analysis. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2016;87(2):273-82. doi: 10.1002/ccd.26063. PubMed PMID: 26424295. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26424295.

10. Peelukhana SV, Effat M, Kolli KK, Arif I, Helmy T, Leesar M, Kerr H, Back LH, Banerjee R. Lesion flow coefficient: a combined anatomical and functional parameter for detection of coronary artery disease--a clinical study. The Journal of invasive cardiology. 2015;27(1):54-64. PubMed PMID: 25589702. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25589702.

11. Peelukhana SV, Banerjee R, Kolli KK, Fernandez-Ulloa M, Arif I, Effat M, Helmy T, Kerr H. Benefit of ECG-gated rest and stress N-13 cardiac PET imaging for quantification of LVEF in ischemic patients. Nuclear medicine communications. 2015;36(10):986-98. doi: 10.1097/MNM.0000000000000352. PubMed PMID: 26225941. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26225941.

12. Peelukhana SV, Kolli KK, Leesar MA, Effat MA, Helmy TA, Arif I, Schneeberger EW, Succop P, Banerjee RK. Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model. Heart and vessels. 2014;29(1):97-109. doi: 10.1007/s00380-013-0355-9. PubMed PMID: 23624760. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23624760.

13. Peelukhana SV, Kerr H, Kolli KK, Fernandez-Ulloa M, Gerson M, Effat M, Arif I, Helmy T, Banerjee R. Benefit of cardiac N-13 PET CFR for combined anatomical and functional diagnosis of ischemic coronary artery disease: a pilot study. Annals of nuclear medicine. 2014;28(8):746-60. doi: 10.1007/s12149-014-0869-y. PubMed PMID: 24950752. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24950752.

14. Kolli KK, Helmy TA, Peelukhana SV, Arif I, Leesar MA, Back LH, Banerjee RK, Effat MA. Functional diagnosis of coronary stenoses using pressure drop coefficient: a pilot study in humans. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2014;83(3):377-85. doi: 10.1002/ccd.25085. PubMed PMID: 23785016. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23785016.

15. Kolli KK, Effat MA, Peelukhana SV, Succop P, Back LH, Leesar MA, Helmy TA, Imran A, Banerjee RK. Hyperemia-free delineation of epicardial and microvascular impairments using a basal index. Annals of biomedical engineering. 2014;42(8):1681-90. doi: 10.1007/s10439-014-1020-x. PubMed PMID: 24806315. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24806315.
Kranthi Kolli 7 10/05/2018

16. Kolli KK, Arif I, Peelukhana SV, Succop P, Back LH, Helmy TA, Leesar MA, Effat MA, Banerjee RK. Diagnostic performance of pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve. The Journal of invasive cardiology. 2014;26(5):188-95. PubMed PMID: 24791716. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24791716.

17. Kolli KK, Paul AK, Back LH, Effat MA, Banerjee RK. Optimization of balloon obstruction for simulating equivalent pressure drop in physiological stenoses. Biorheology. 2013;50(5-6):257-68. doi: 10.3233/BIR-130640. PubMed PMID: 24398608. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24398608.

18. Peelukhana SV, Banerjee RK, Kolli KK, Effat MA, Helmy TA, Leesar MA, Schneeberger EW, Succop P, Gottliebson W, Irif A. Effect of heart rate on hemodynamic endpoints under concomitant microvascular disease in a porcine model. American journal of physiology Heart and circulatory physiology. 2012;302(8):H1563-73. doi: 10.1152/ajpheart.01042.2011. PubMed PMID: 22287585. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22287585.

19. Kolli KK, Banerjee RK, Peelukhana SV, Effat MA, Leesar MA, Arif I, Schneeberger EW, Succop P, Gottliebson WM, Helmy TA. Effect of changes in contractility on pressure drop coefficient and fractional flow reserve in a porcine model. The Journal of invasive cardiology. 2012;24(1):6-12. PubMed PMID: 22210582. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22210582.

20. Rajabi-Jaghargh E, Kolli KK, Back LH, Banerjee RK. Effect of guidewire on contribution of loss due to momentum change and viscous loss to the translesional pressure drop across coronary artery stenosis: an analytical approach. Biomedical engineering online. 2011;10:51. doi: 10.1186/1475-925X-10-51. PubMed PMID: 21658283; PMCID: 3141581. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21658283.

21. Kolli KK, Banerjee RK, Peelukhana SV, Helmy TA, Leesar MA, Arif I, Schneeberger EW, Hand D, Succop P, Gottliebson WM, Effat MA. Influence of heart rate on fractional flow reserve, pressure drop coefficient, and lesion flow coefficient for epicardial coronary stenosis in a porcine model. American journal of physiology Heart and circulatory physiology. 2011;300(1):H382-7. doi: 10.1152/ajpheart.00412.2010. PubMed PMID: 20935151. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20935151.

Research Interest: Functional Brain Imaging, Pre-surgical Brain Mapping, Biomedical signal and Image Processing, Neural Engineering

Research Interest: Applied research specifically in tissue engineering, biomaterials and regenerative medicine. Currently focus is bionanomedicine, bionanocomposites and bionanotechnology

Research Interest: Since 2008 Paola Saccomandi has been involved in research activities in the fields of biomedical instrumentations and measurements applied to medicine. From 2008 to 2011 she worked under the supervisio of Prof. Sergio Silvestri and Dr. Emiliano Schena in the fied of mechanical ventilation. In particular she worked on development of optoelectronic and fiber optic-based flow sensors, as well as on ventilatory gases humidification. In 2011 she started her main research activity in the field of laser ablation of cancer, with particular regard to pancreatic tumor. She developed a mathematic model aiming to predic effects of laser light o pancreas, in terms of ablated volume and temperature distribution. Since 2012 she has been investigating the field of invasive (fiber optic sensors, thermocouples) and non-ivasive (based on diagnostic images) thermometry for temperature monitoring during laser ablation of tumour. In this activity she is actively collaborating with the team of research of the Institute for Diagnostic and Interventional Radiology of J. W. Goethe Universität Frankfurt am Main, headed by Prof. Thomas J. Vogl. Since 2013 she has been working in the fied of optical characterization of biological tissue, aiming to estimate optical properties of pancreas. She is collaborating with the team of Biophysics Institute J. W. Goethe Universität Frankfurt am Main, headed by Prof. Werner Mäntele. In the framework of laser ablation for the removal of pancreatic cancer, she has participated at the study approved by UCBM Ethics Committee -ComEt UCBM-, Prot. N. 4011/2011. The study aims to treat with laser ablation patients with inoperable pancreatic cancer. Since 2014 she is also involved in the design and development of tactile sensors for robotic artificial prosthetics

Research Interest: Time-domain optical brain imaging, functional near-infrared  ectroscopy,  fluorescence measurements, analyses of an optical properties of the media, development of optical imaging systems, brain optics, clinical applications

Research Interest: Nano-Biomaterials Development, Cellular and Tissue Engineering Drug and Gene Delivery, Molecular Diagnostics Photobioreactor Design

Dr. Mohammed Rachidi received his PhD/ Doctorate Degree in Human and Molecular Genetics (with High Honors) at the prestigious ''Pasteur Institute'' (Paris, France), in the Department of Molecular and Cellular Genetics headed by the Professor François JACOB (Nobel Prize in Physiology/Medicine), where he studied the Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System development, CaMKinases & Biological Clock Function in Drosophila. Dr. Rachidi extended these Molecular Genetics works to Functional Genomics at Pasteur Institute and at Center National of Research Scientific CNRS and played key fundamental roles in different collaborative research projects with prestigious laboratories in Europe, Japan & United States. Remarkably, Dr. Rachidi collaborated with the Professor Michael ROSBASH (Nobel Prize in Physiology/Medicine 2017) in the Molecular Mechanisms of 2 genes involved in Circadian Clock.  Dr. Rachidi published with Professor ROSBASH this important work in the EMBO Journal Entitled : ''A New Gene encoding a putative Transcritpion Factor Regulated by the Drosophila Circadian Clock''. Postdoctoral training & Assistant Professor with Professor Nicole LeDOUARIN at the prestigious ''College De France'' & Institute of Cellular & Molecular Embryology (Paris), Dr. Rachidi studied some Chicken & Xenopus molecules acting in Bone Morphogenetic Protein BMP signaling pathways and identified their Mouse & Human homologs involved in differentiation of specific domains of neuronal progenitors, in cerebellum development and Joubert syndrome (a form of cerebellar ataxia). These experiences of Dr. Rachidi in the Molecular Genetics and in several Animal Models were extended to Human Molecular Genetics of Down syndrome (DS) & to Molecular and Cellular Mechanisms underlying Brain morphogenesis of Trisomic & Transgenic Mouse Models of DS and also of numerous stages of Embryonic & Fetal DS patients to elucidate the Neurogenetic Basis of Functional alterations Associated with Mental Retardation. Director of Research in Human Molecular Genetics, Faculty of Medicine University Paris 5 (France), with High Honours for Notable Scientific Research Contributions, Breakthroughs & Discoveries in Drosophila & Mouse & Human Molecular Genetics & Neurosciences, Dr. Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neuroscience & Biomedical Research. Dr. Rachidi realized numerous ''Discoveries and Innovations'' to name a few:  (1) - Discovery of Quantitative Assessment of Gene [removed]QAGE) as a New Method in situ detecting Differential Overexpression of Candidate Genes for Mental Retardation in Down syndrome Brain Regions & for Other Diseases caused by Regionalized Quantitative Transcriptional Alterations for greater interpretation of functional processes driving gene expression. (2) - Discovery of New Cerebellar & Cerebral Phenotypes in Transgenic mouse in vivo Library of Human Down syndrome Critical Region. (3) - Discovery of a Novel Light Microscopy Technology as Powerful Tool in Developmental Biology & Biomedical & Neuroscience Research. (4) - Discovery of New Genes involved in Brain Morphogenesis & in Visual System development; in Biological Clock; in Learning & Memory and in Mental Retardation in Down syndrome & Joubert syndrome. (5) - Discovery of the First Proposed Model of Molecular and Cellular Mechanism Elucidating Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Mental Retardation in Down syndrome: in this Model Gene Dosage Effects on transcriptional variations and the nature of gene products and their functional relationships are explained with the different aspects of neuronal differentiation. Dr. Rachidi published numerous articles in highly Prestigious International Journals with High Impact Factor like EMBO, Genomics, DNA Research, Gene, Mechanisms of Development, Cytogenetics & Genome Research, Neuroscience Research, International Journal of Developmental Neuroscience, Cell Tissue Research, American Journal of Intellectual Developmental Disability, European Journal of Paediatric Neurology...and in numerous journals of Elsevier & Springer. He has also authored numerous Chapters & Books. Dr. Rachidi has been honoured worldwide as Invited Distinguished Speaker, Chairman or Invited Honourable Organizing Committee Member in numerous International Conferences, Seminars & Workshops in Europe, USA & Asia. Dr Rachidi received numerous Awards & Honors and He is an Editor, Associate Editor, Executive Editor & Editor in Chief in numerous International peer-reviewed Journals.

Research Interest:

Dr. Mohammed Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neurosciences & Biomedical Research, to name a few : Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System, Biological Clock, Synaptic Protein Targeting, Synaptic Plasticity, CaMKII & CAMGUK/MAGUK, Learning and Memory. Functional Genomics & Mechanisms controlling Transposition at Cell Cycle. Transcription, Protein Translation & Virus-Like Particle Formation. Bone Morphogenetic Protein BMP signaling pathways, Mouse and Human Homeobox Genes, Cell Fate Determination and Differentiation, Neuronal Progenitors in Cerebellum development and Joubert syndrome. Trisomy 21, Intellectual Disability, Candidate Genes, Expression studies, Genotype-Phenotype Associations, Trisomic and Transgenic Mouse Models of Down syndrome, Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability.  Drosophila & Mouse & Human.

List of Publications:

- Rachidi, M. (2019). Pharmacotherapeutic Challenges for Rescuing Mental Retardation and Improving Brain Function in Down Syndrome.  Biophamaceutics and Therapeutic Challenges, 2019, (In Press).

- Rachidi, M. (2018). The Genetic Dosage Imbalance Linked to Clinical Brain Alterations and Mental Disability in Down syndrome could be Targeted for Therapeutics Development.
Medical Journal of Clinical Trials and Case studies. 2018, 2 (5): 000150.

- Rachidi, M. (2018). The Molecular Pathogenesis of Down Syndrome-Associated Diseases and the Promising Potential Therapeutic Targets.
Clinical and Medical Investigations, 2018, Vol. 3(1), 1-2.

- Rachidi, M. (2018). Trisomy of Chromosome 21 provides a Genetic Model for the Role of Aneuploidy in Cell Cycle Alterations, Leukemia, Tumors and Cancer   (In Press).

- Rachidi, M. (2016). Neurogenetic Disorders of Down Syndrome and Potential Pharmacotherapies for Mental Retardation.
American Journal of Clinical Neurology and Neurosurgery, 2016, Vol. 2, No. 4, 2016, pp. 45-49.

- Rachidi, M. (2015). Towards the Identification of Genetic Targets for Therapeutics of Intellectual Disability in Down syndrome.
J.J. Cenetics, 2015.

- Rachidi, M. and Lopes, C. (2013).  Mental Retardation and Human Chromosome 21 Gene Overdosage: From Functional Genomics and Molecular Mechanisms towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome.
Handbook of Neurochemistry and Molecular Neurobiology. In Genomics, Proteomics, and the Nervous System, Advances in Neurobiology, Springer Publishers 3rd Ed 2013.

- Rachidi M., Tetaria C., Lopes C. (2011). “Cell cycle alteration in Down syndrome”. In Berhardt LV. (Ed.), Advances in Medicine and Biology, 2011, Vol. 20. Nova Science Publisher.

- Rachidi, M. and Lopes, C. (2010). Molecular and Cellular Mechanisms Elucidating the Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability in Down syndrome.
American Journal of  Intellectual Developmental Disabilities, 2010; 115., 83-112.

- Rachidi, M. and Lopes, C. (2010). Cell Cycle Alteration in Down syndrome.
International Journal of Medical and Biological Frontiers, 2010, Volume 16, Issue 3/4,  Nova Science Publishers.

- Rachidi, M. and Lopes, C. (2009). Gene Expression Regulation in Down syndrome: Dosage Imbalance Effects at Transcriptome and Proteome Levels. Handbook of Down syndrome Research, Edition Nova Science Publishers, Inc., 2009, 55-87

- Rachidi, M., Delezoide, A-L., Delabar, J.M. and Lopes, C. (2009). A quantitative assessment of gene [removed]QAGE) reveals differential overexpression of DOPEY2, a candidate gene for mental retardation, in Down syndrome brain regions.
International Journal of Developmental Neuroscience, 2009, 27, 393-398.

- Rachidi, M., Tetaria, C., and Lopes, C. (2008). Trisomy of Human Chromosome 21 and Cell Cycle Control. In Leroy NH., Fournier NT. (Eds.): Cell Cycle Control: New Research, Nova Science Publishers, Inc., 2008, 159-189.

- Rachidi, M. and Lopes, C. (2008). Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways.
European Journal of Paediatric Neurology, 2008, 12, 168-182.

- Rachidi, M. and Lopes, C. (2008). Molecular Mechanisms of Mental Retardation in Down syndrome. Rachidi, M. and Lopes, C. (Editors), Nova Biomedical Book: Edition Nova Science Publishers, Inc., 2008, pp 1-94.

- Rachidi, M., Lopes, C.; C Vayssettes, D J. Smith, E M Rubin, J.M Delabar. (2007). New Cerebellar Phenotypes in YAC Transgenic mouse in vivo Library of Human Down syndrome Critical Region 1.
Biochemical Biophysical Research Communications, 2007, 364(3), 488-494.

- Rachidi, M. and Lopes, C. (2007). Molecular Mechanisms of Mental Retardation in Down Syndrome. In Carson MI. (Ed.): Focus on Mental Retardation Research. Nova Science Publishers, Inc. 2007, pp. 77-134.

- Rachidi, M. and Lopes, C. (2007). Mental retardation in Down syndrome: From gene dosage imbalance to molecular and cellular mechanisms.
Neuroscience Research, 2007, 59(4), 349-369.

- Rachidi, M. and Lopes, C. (2006). Differential transcription of Barhl1 homeobox gene in restricted functional domains of the central nervous system suggests a role in brain patterning.
International Journal of Developmental Neuroscience, 2006, 24(1), 35-44.

- Rachidi, M., Lopes, C., Delezoide, A.L. and Delabar, J.M. (2006). C21orf5, a human candidate gene for brain abnormalities and mental retardation in Down Syndrome.
Cytogenetics and Genome Research, 2006, 112(1-2), 16-22.

- Lopes, C., Delezoide, A.L., Delabar, J.M. and Rachidi, M. (2006). BARHL1 homeogene, the human ortholog of the mouse Barhl1 involved in cerebellum development, shows regional and cellular specificities in restricted domains of developing human central nervous system.
Biochemical Biophysical Research Communications, 2006, 339, 296-304.

- Rachidi, M., Lopes, C., Costantine, M. and Delabar J.M. (2005). C21orf5, a new member of dopey family involved in morphogenesis, could participate to neurological alterations and mental retardation in Down syndrome.
DNA Research, 2005, 12, 203-210.

- Rachidi, M., Lopes, C., Charron, G., Delezoide, AL., Paly, E., Bloch, B. and Delabar, JM. (2005). Spatial and temporal localization during embryonic and fetal human development of the transcription factor SIM2 in brain regions altered in Down syndrome.
International Journal of Developmental Neuroscience, 2005, 23, 475-484.

- Rachidi, M., Lopes, C., Benichou, J.C., Hellio, R. and Maisonhaute, C. (2005). Virus-like particle formation in Drosophila melanogaster germ cells suggests a complex translational regulation of the retrotransposon cycle and new mechanisms inhibiting transposition.
Cytogenetics and Genome Research, 2005, 111(1), 88-95.

- Lopes, C., Chettouh, Z., Delabar, J.M. and Rachidi, M. (2003). The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice. Biochemical Biophysical Research Communications, 2003, 305, 915-924.

- Takamatsu, Y., *Nakagoshi, H., *Rachidi, M., Lopes, C. Nishida, Y. and Ohsako, S. (2002). Characterization of the dCaMKII-GAL4 driver line whose expression is controlled by the. Drosophila Ca²+/calmodulin dependent protein kinase II promoter.
Cell Tissue Research., 2002, 310(2), 237-252.

- Lopes, C., Gassanova, S., Delabar, J.M. and Rachidi, M. (2001). The CASK/Lin-2 Drosophila Homologue, Camguk, Could Play a Role in Epithelial Patterning and in Neuronal Targeting.
Biochemical Biophysical Research Communications, 2001, 284(4), 1004-1010.

- Lopes, C., Rachidi, M., Charron, G., Chamoun, Z., Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B., Delezoide, A.L. and Delabar, JM. (2001). Conservation of the CNS expression pattern of new genes from the Down syndrome chromosomal region-1: human genes and their murine orthologs.
Cytogenetics and Cell Genetics, 2001, 92(1-2), 1-22.

- Rachidi, M., Lopes, C., Gassanova, S., Sinet, P.M., Vekemans, M., Attie, T., Delezoide, A.L. and Delabar, J.M. (2000). Regional and cellular specificity of TPRD, the tetratricopeptide Down Syndrome gene, during embryonic development.
Mechanisms of Development, 2000, 93(1-2), 189-193.

- Delabar, J.M., Rachidi, M., Lopes, C., Charron, G., Chamoun, Z, Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B. and Delezoide, A.L. (2000). Conservation of the CNS expression pattern of new genes from the Down Syndrome Chromosomal Region-1: Human genes and their Murine orthologs.
European Journal Neuroscience, 2000, 12(Supp 11), 297.

- Orti, R., Rachidi, M., Viallard, F., Toyama, K., Lopes, C., Taudien, S., Rosenthal, A., Sinet, P.M. and Delabar, J.M. (2000). Characterisation of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and its murine ortholog.
Genomics, 2000, 64(2), 203-210.

- Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1999). Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues.
European Journal of Human Genetics, 1999, 7(Supp.1), 111.

- Rachidi, M., Lopes, C., Takamatsu, Y., Ohsako, S., Benichou J.C. and Delabar, J.M. (1999). Dynamic expression pattern of Ca2+/calmodulin-dependent protein kinase II gene in the central nervous system of Drosophila throughout development.
Biochemical Biophysical Research Communications, 1999, 260(3), 707-711.

- Lopes, C., Rachidi, M., Gassanova, S., Sinet, P.M. and Delabar, J.M. (1999). Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1.
Mechanisms of Development, 1999, 84(1-2), 189-193.

- Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1998). Expression of the Mnb (dyrk) protein in adult and embryonic mouse tissues.
Biochemical Biophysical Research Communications,  1998, 253(2), 514-518.

- Rachidi, M., Lopes, C. and Benichou, J.C. (1997). Genetical analysis of visual system disorganizer (vid), a new gene involved in normal development of eye and optic lobe of the brain in Drosophila melanogaster. 
Genetica, 1997, 99, 31-45.

- Rachidi, M., Lopes, C., Benichou, J.C. and Rouyer, F. (1997). Analyse of period circadian expression in the Drosophila head by in situ hybridization. Journal of Neurogenetics, 1997, 11, 255-263.

- Rouyer, F., Rachidi, M., Pikielny, C. and Rosbash, M. (1997). A new gene encoding a putative transcritpion factor regulated by the Drosophila circadian clock.
EMBO Journal, 1997, 16(13), 3944-3954.

- Haoudi, A., Rachidi, M., Kim, M.H., Champion, S., Best-Belpomme, M. and Maisonhaute, C. (1997). Developmental expression analysis of the 1731 retrotransposon reveals an enhancement of Gag-Pol frameshifting in males of Drosophila melanogaster.
Gene, 1997, 196 (1-2), 83-93.

- Fassouane, A., Rachidi, M., Rouffaud, M.A., El-Abbouyi, A. and Nguyen, V.H. (1995). In vitro antifungal activity of Bacillus licheniformis FSJ-2 products against dermatophytes.
Journal of Mycology and Medicine, 1995, 5, 244-248.

- Rachidi, M. (1993). The Drosophila visual system: An elaborated building and a powerful model for developmental studies. Biomatec Journal, 1993, 4-5, 2-8.