Research Interest: Super-resolution technology; Stochastic Optical Reconstruction Microscopy(STORM); Cell Imaging and Structure; Propagation and Scattering of Light in Random and Complex Media; Classical Coherence Theory; Laser Communications and LaserRadar Systems; Near-field Scattering; Optical Imaging System

Research Interest: Surgical planning and simulation in esthetical facial surgeryTelemedicine o Biomedical engineering 

Research Interest: Biophotonics and Biosensors

Research Interest: Tissue & organ repair and regeneration, Tissue engineering, Wound healing, Clinical medicine, dimensional tissue equivalent models, Novel wound and scar remediation therapies, Chinese herbal medicine, Growth factor/extracellular matrix protein complexes, Pharmaceutical and drugs

Research Interest: Development of new lanthanide complexes for MRI and optical imaging: synthesis, purification (HPLC, flash chromatography) and physicochemical characterization (NMR spectroscopy, mass spectrometry, luminescence, UV-visible, FTIR).  

Research Interest: Bone and cartilage disease modeling, drug screening and gene correctionDirect differentiation of pluripotent stem cells toward cartilage and boneBone reprogramming of fibroblasts using defined factors Gene therapy for cartilage regeneration and repair in regenerative medicine Signaling pathway of genes regulating cartilage differentiation of human mesenchymal stem cells.Molecular basis of mesenchymal stem cells maintaining their stemness. Stem cell biology and technique

Publications List:

1. Liu TM*, Yingnan Wu. Editorial: Advancing Gene and Cell Therapy using Human Mesenchymal Stem Cells. Front Cell Dev Biol, 2023, 11:1294460. doi: 10.3389/fcell.2023.1294460. eCollection 2023. (IF 6.081, *corresponding author). Published on 13 Oct 2023.
2. Yufeng Shou, Ling Liu, Zhicheng Le, Khang Leng Lee, Xianlei Li, DionZhanyun Koh, Yuwen Wang, Tong Ming Liu, Zheng Yang, Chwee Teck Lim, Christine Cheung, Andy Tay. Mechano-responsive hydrogel for directing stem cell manufacturing and therapy. Bioact Mater, 2023, 24:387-400. doi: 10.1016/j.bioactmat.2022.12.019. eCollection 2023 Jun. eCollection 2023 Jun. (IF 16.44). (2023 Jan 2)
3. Liu TM*. Application of mesenchymal stem cells derived from human pluripotent stem cells in regenerative medicine. World J Stem cells, 2021,13(12): 1826-1844. doi: 10.4252/wjsc.v13.i12.1826  (Invited review, IF 5.326, *corresponding author). (2021 Dec 26)
4. Srinivasan A, Sathiyanathan P, Yin L, Liu TM, Lam A, Ravikumar M, Smith RAA, Loh HP, Zhang Y, Ling L, Ng SK, Yang YS, Lezhava A, Hui J, Oh S, Cool SM. Strategies to Enhance Immunomodulatory Properties and Reduce Heterogeneity in Mesenchymal Stromal Cells during ex vivo Expansion. Cytotherapy (IF 5.414). 2022 May;24(5):456-472. doi: 10.1016/j.jcyt.2021.11.009. Epub 2022 Feb 25. PMID: 35227601
5. Liu TM*, Yildirim ED, Li P, Fang HT, Denslin V, Kumar V, Loh YH, Lee EH, Cool SM, Teh BT, Hui JH, Lim B, Shyh-Chang N. Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells.  Stem Cell Reports, 2020, 14:210-225 (IF 7.765, *corresponding author, cited 7). doi: 10.1016/j.stemcr.2020.01.002. Epub 2020 Jan 30. 11 February 2020.
6. Liu TM*. Regulation of chondrogenesis. Ann Stem Cell Res Ther. 2019; 3(1): 1028. (Invited Editorial, *corresponding author).
7. Liu TM, Shyh-Chang N. SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nat Cell Biol. 2017 Apr 27; 19(5):412-414. doi: 10.1038/ncb3522 (IF 20.06, cited 12).
8. Liu TM*. Stemness of Mesenchymal Stem Cells. J Stem Cell Ther Transplant. 2017; 1: 071-073 (Invited Editorial, *corresponding author, cited 9).
9. Cheng H, Ang HY, A El Farran C, Li P, Fang HT, Liu TM, Kong SL, Chin ML, Ling WY, Lim EK, Li H, Huber T, Loh KM, Loh YH, Lim B. Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors. Nat. Commun. 2016 Nov 21; 7:13396. doi: 10.1038/ncomms13396 (IF 11.3, cited 17).
10. Liu TM*, Lee EH, Lim B, Shyh-Chang N. Balancing Stem Cell Self-renewal and Differentiation with PLZF. Stem cells, 2016 Feb; 34(2):277-87. doi: 10.1002/stem.2270. Epub 2016 Jan 5 (IF 7.133, *corresponding author, cited 54).
11. Liu TM*. Stem Cell-Based Therapies for Cartilage Repair and Regeneration. J Stem Cells Res, Rev &. Rep. 2014, 1(1): 1-2 (Invited Editorial, *corresponding author).
12. Tan HK, Toh CX, Ma D, Yang B, Liu TM, Lu J, Wong CW, Tan TK, Li H, Syn C, Tan EL, Lim B, Lim YP, Cook SA, Loh YH. Human Finger-Prick Induced Pluripotent Stem Cells Facilitate the Development of Stem Cell Banking. Stem Cells Transl Med. 2014 May; 3(5):586-98. doi: 10.5966/sctm.2013-0195. Epub 2014 Mar 19. (IF 5.709, cited 42)
13. Liu TM*, Lee EH. Transcriptional regulatory cascades in Runx2-dependent bone development. Tissue Eng Part B Rev, 2013, 19(3):254-63. doi: 10.1089/ten.TEB.2012.0527. (*corresponding author). (IF 4.448, cited 238)
14. Liu TM*, Ng WM, Tan HS, Vinitha D, Yang Z, Fan JB, Zou Y, Hui JH, Lee EH, Lim B. Molecular basis of immortalization of human mesenchymal stem cells by combination of p53 knockdown and human telomerase reverse transcriptase overexpression. Stem Cells Dev. 2013 Jan 15; 22(2):268-78. doi: 10.1089/scd.2012.0222. Epub 2012 Aug 21. (IF4.67, *corresponding author, cited 67).
15. Liu TM*. Gene therapy for articular cartilage repair. Pharmaceutica Analytica Acta, 2012,3:e1112. doi:10.4172/2153-2435.1000e112 (Invited Editorial, *Corresponding author).
16. Yang Z, Zou Y, Guo XM, Tan HS, Denslin V, Yeow CH, Ren XF, Liu TM, Hui JH, Lee EH. Temporal activation of ß-catenin signaling in the chondrogenic process of mesenchymal stem cells affects the phenotype of the cartilage generated. Stem Cells Dev. 2012, 21:1966-1976. 2011 Dec 1. [Epub ahead of print]. (IF4.791, cited 35).
17. Liu TM^*, Guo XM, Tan HS, Hui JH, Lim B, Lee EH. Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair. Arthritis Rheum. 2011 Sep; 63(9):2711-20. doi: 10.1002/art.30430. (IF8.435, *Corresponding author, cited 72).
18. Liu T, Liu L, Wei Q, Hong Y. Sperm nuclear transfer and transgenic production in the fish medaka. Int J Biol Sci, 2011, 7(4): 469-475. (IF 3.215, cited 22)
19. Liu TM, Wu YN, Guo XM, Hui JH, Lee EH, Lim B. Effects of ectopic Nanog and Oct4 overexpression on mesenchymal stem cells. Stem Cells Dev. 2009 Sep;18(7):1013-22. doi: 10.1089/scd.2008.0335. (IF4.45, cited 164)
20. Liu TM, Martina M, Hutmacher DW, Hui JH, Lee EH, Lim B. Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells. 2007 Mar;25(3):750-60. doi: 10.1634/stemcells.2006-0394. Epub 2006 Nov 9. (IF 7.751, cited 524)
21. Lian Q, Lye E, Suan Yeo K, Khia Way Tan E, Salto-Tellez M, Liu TM, Palanisamy N, El Oakley RM, Lee EH, Lim B, Lim SK. Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs. Stem Cells. 2007 Feb; 25(2):425-36. doi: 10.1634/stemcells.2006-0420. Epub 2006 Oct 19. (IF 7.751, cited 298).
22. Y.H. Hong, T.M. Liu, H.B. Zhao, H.Y. Xu, W.J. Wang, R. Liu, T.S. Chen. Establishment of a normal medakafish spermatogonial cell line capable of sperm production in vitro. Proc. Natl. Acad. Sci. USA., 2004, 101(21): 8011-8016. (IF 10.3, cited 213)
23. Y.H. Hong, C. Winkler, T.M. Liu, G.X. Chai, M. Schartl. Activation of the mouse Oct4 promoter in medaka embryonic stem cells and its use for ablation of spontaneous differentiation. Mech. Dev., 2004, 121: 933-943. (IF 3.16, cited 61)
24. TM Liu, QJ Wu, YZ Ye. Studies on the artificial induce gynogenesia and the sex revesal in loach (Misgurnus anguillicaudatus). Acta Hydrobiologica Sinica, 2004, 28: 445-447 (cited 6).
25. TM Liu, XM Yu, YZ Ye, JF Zhou, ZW Wang, JG Tong, QJ Wu. 2002. Factors affecting the efficiency of somatic cell nuclear transplantation in the fish embryo. The Journal of Experimental Zoology, 2002, 293:719-725 (cited 20)
26. T. M. Liu, Q. J. Wu, X. M. Yu, X.Y. Li. Effects of cell-cycle arrest agents on cleavage and development of loach (Misgurnus anguillicaudatus) embryos. Fish Physiology and Biochemistry, 2002, 25:3-9.
27. TM Liu, XM Yu, YZ Ye, ZW Wang, JF Zhou, QJ Wu. Studies on factors affecting the development of embryos from somatic cell nuclear transplantation in the fish. Zoological Research, 2002, 23(2): 107-112.
28. YD Liu, LR Song, XY Li, TM Liu. The toxic effects of microcystin-LR on embry-larval and juvenile development of loach, Misgurnus Mizolipis Gunthe. Toxicon, 2002, 40(4): 395-399 (cited 137).
29. TM Liu and QJ Wu. 2000. Progress of nuclear transplantation in teleost.   Biotechnology Information, 6:24-28.
30. TM Liu, JW Cao, LY Wan, Y Liu, YX Yu. Subcloning of alkalophilic gene from alkalophilic Bacillus sp. NTT36 and its expression in Escherichia coli and Agrobacterium tumefaciens. Amino Acids & Biotic Resources, 1999, 21(2): 37-40.
31. LY Wang, JW Cao, TM Liu, XQ Zhang. Cloning and expression of promoter from an alkalophilic Bacillus sp. NTT89 in Escherichia coli. Journal of Wuhan University (Natural Science Edition), 2000, 46(2): 257-260.
32. Y Gong, JW Cao, TM Liu. Clone and subclone of the alkalophilic gene from alkalophilic Bacillus sp. NTT36 and analysis of expressed products in E.coli. Journal of Wuhan University (Natural Science Edition), 1998, 44(6): 775-780.

Research Interest: Developing inexpensive and portable optical technologies that can provide a rapid bedside assessment of brain function and health.

Research Interest:  Designing and preparing new nanobiomaterials Characterizing physical and chemical properties, biocompatibility and bioactivity of the nanobiomaterials

Research Interest:  His research interests concentrate on the biosensors (e.g. living cell sensor, DNA sensor and protein sensor) and BioMEMS system.

Research Interest: Berber phonetics, Automatic Speech processing, Speech disorders Acoustic phonetics, Automatic Speech Recognition, Speech Synthesis, Artificial Neural NetworksArabic phonetics

Research Interest:  His research interests concentrate on the biosensors (e.g. living cell sensor, DNA sensor and protein sensor) and BioMEMS system.

Dr. Rajasekharredy Pala is a Nano biotechnologist specialized in the synthesis of various metal and metal oxide nanoparticles with their application as drug delivery agents to the primary cilia. After his post-graduation he was selected for ICMR-Senior Research Fellowship under Biomedical Sciences in 2011 and during this period of his doctoral studies at CSIR-Indian Institute of Chemical Technology, India, he has earned handsome experience on the physical and chemical characterizations techniques of nanoparticles that are enveloped with various biologically active compounds such as protein, lipids and small molecular drugs for their biomedical applications. Dr. Pala working as a research associate in Chapman University and University of California Irvine from 2015.

Research Interest: Nanomedicine, Hypertension, Cancer, Renal diseases

URL: https://sites.chapman.edu/cilia/pala-rajasekharreddy/

Skype ID: raaja.biotech

List of Publications: 

Rajasekharreddy Pala, Ashraf M. Mohieldin, Kiumars Shamloo, Rinzhin T. Sherpa, Sarmed H.

Kathem, Jing Zhou, Zhongyue Luan, Jian-Guo Zheng, Amir Ahsan, and Surya M. Nauli.

Personalized Nanotherapy by Specifically Targeting Cell Organelles To Improve Vascular

Hypertension. Nano Letters Article ASAP DOI: 10.1021/acs.nanolett.8b04138

2. Zeng, Y., Zhu, J., Wang, J., Parasuraman, P., Busi, S., Nauli, S. M., Wáng, Y., Pala,

Rajasekharreddy, Liu, G. (2018). Functional probes for cardiovascular molecular

imaging. Quantitative imaging in medicine and surgery, 8(8), 838-852 (co-corresponding

author).

3. Pala, Rajasekharreddy., Jamal, M., Alshammari, Q., Nauli, S.M. The Roles of Primary Cilia in

Cardiovascular Diseases. Cells 2018, 7, 233. (Published as cover page)

4. Rajasekharreddy Pala, Yun Zeng, Subhaswaraj Pattnaik, Siddhardha Busi, Alomari Nedaa,

Nauli Surya M, Gang Liu, (2018). Functionalized Silver Nanoparticles for Sensing, Molecular

Imaging and Therapeutic Applications. Current Nanomedicine, Pages 1 - 17 (17).

5. Pala Rajasekharreddy, Pathipati Usha Rani, Mattapally Saidulu & Sanjay K. Banerjee (2017).

Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus

aureus disease in silkworm model, Materials Science and Engineering: C, 77, 990-1002

(corresponding author).

6. Pala Rajasekharreddy, Chao Huang, Siddhardha Busi, Jobina Rajkumari, Ming-Hong Tai, Gang

Liu (2017). Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment:

Principles, Challenges and the Road Ahead. Current Medicinal Chemistry, 24, 1-17. Doi.

10.2174/0929867324666170309124327.

7. Jobina Rajkumari, Siddhardha Busi, Aneesh Cherukunnel Vasu, Pala Rajasekharreddy (2017),

Facile green synthesis of baicalein fabricated gold nanoparticles and their antibiofilm activity

against Pseudomonas aeruginosa PAO1. Microbial Pathogenesis, 107: 261-269.

8. Rajasekharreddy Pala, Nedaa Alomari, Surya M. Nauli (2017). Primary Cilium-Dependent

Signaling Mechanisms, International Journal of Molecular Sciences, 18, 2272.

9. Kiumars Shamloo, Juan Chen, Jasmine Sardar, Rinzhin T. Sherpa, Rajasekharreddy

Pala, Kimberly F. Atkinson,William J. Pearce, Lubo Zhang, Surya M. Nauli (2017). Chronic

Hypobaric Hypoxia Modulates Primary Cilia Differently in Adult and Fetal Ovine Kidneys.

Frontiers in Physiology, 8: 677.

10. Nauli, Surya M., Rajasekharreddy Pala, and Steven J. Kleene (2016). "Calcium channels in

primary cilia." Current Opinion in Nephrology and Hypertension 25 (5): 452-458.

11. Pala Rajasekharreddy and Pathipati Usha Rani (2014). Biofabrication of Ag nanoparticles using

Sterculia foetida L. seed extract and their toxic potential against mosquito vectors and HeLa

cancer cells. Materials Science and Engineering: C, 39, 203-212.

12. Pala Rajasekharreddy and Pathipati Usha Rani (2014). Biosynthesis and characterization of Pd

and Pt nanoparticles using Piper betle L. plant in a photoreduction method. Journal of Cluster

Science, 25: 1377-1388.

13. Praveen Kumar Kalavagunta, Rajasekharreddy Pala, Usha Rani Pathipati and Narender Ravirala

(2014). Identification of β-Naphthol derivatives as novel antifeedants and insecticides-I. Journal

of Agricultural and Food Chemistry, 62, 6571−6576.

14. Pala Rajasekharreddy and Pathipati Usha Rani (2012) Nontoxic effects of biologically

synthesized silver nanoparticles on silkworm, Bombyx mori L. Hexapoda 19 (1): 74–78.

Pathipati Usha Rani and Pala Rajasekharreddy (2011) Green synthesis of silver-protein (core–

shell) nanoparticles using Piper betle L. leaf extract and its ecotoxicological studies on Daphnia

magna. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 389 (1-3): 188-194.

16. Pathipati Usha Rani, Pala Rajasekharreddy and Kommu Nagaiah (2011). Allelopathic effects of

(2n-octylcycloprop-1-enyl)-octanoic acid (I) against Four Major Weeds. Allelopathy Journal. 28

(2) 179-188.

17. Pala Rajasekharreddy, Pathipati Usha Rani and Bojja Sreedhar (2010). Qualitative assessment of

silver and gold nanoparticle synthesis in various plants: a photobiological approach. Journal of

Nanoparticle Research, 12: 1711-1721.

18. Pala Rajasekharreddy and Pathipati Usha Rani (2010). Toxic properties of certain botanical

extracts against three major stored product pests. Journal of Biopesticides. 3(3): 586-589.

19. Pathipati Usha Rani and Pala Rajasekharreddy (2010). Insecticidal activity of (2n-octylcycloprop-

1-enyl)-octanoic acid (I) against three coleopteran stored product insects from Sterculia foetida

(L.). Journal of Pest Science, 83(3); 273-279.

20. Pathipati Usha Rani and Pala Rajasekharreddy (2009). Toxic and antifeedant activities of Sterculia

foetida (L.) seed crude extract against Spodoptera litura (F.) and Achaea janata (L.). Journal of

Biopesticides 2(2): 161-164.

Pathipati Usha Rani and Pala Rajasekharreddy (2013). Plants: The green factories for synthesis

of nanomaterials” in the book “Nanotechnology Environment” Edited by J.N. Govil. Studium Press

LLC, USA.

A method for isolation of an Ortho Quinone Methide intermediate. Pala Rajasekharreddy

and K.P Kumar and (PCT/IB2015/057628), WIPO publication no. WO/2016/059511.

• Green synthesis of highly monodispersed silver nanoparticles by plant. P. Usha Rani and Pala

Rajasekharreddy (File No. 4020/DEL/2012).

• Novel synthesis of 2-aminobenzothiazolomethyl naphthol derivatives and their

antifeedant activity. KP Kumar, Pala Rajasekharreddy, V. Narendar & P. Usha Rani (File No

0802/DEL/2013).

Research Interest: Since 2008 Paola Saccomandi has been involved in research activities in the fields of biomedical instrumentations and measurements applied to medicine. From 2008 to 2011 she worked under the supervisio of Prof. Sergio Silvestri and Dr. Emiliano Schena in the fied of mechanical ventilation. In particular she worked on development of optoelectronic and fiber optic-based flow sensors, as well as on ventilatory gases humidification. In 2011 she started her main research activity in the field of laser ablation of cancer, with particular regard to pancreatic tumor. She developed a mathematic model aiming to predic effects of laser light o pancreas, in terms of ablated volume and temperature distribution. Since 2012 she has been investigating the field of invasive (fiber optic sensors, thermocouples) and non-ivasive (based on diagnostic images) thermometry for temperature monitoring during laser ablation of tumour. In this activity she is actively collaborating with the team of research of the Institute for Diagnostic and Interventional Radiology of J. W. Goethe Universität Frankfurt am Main, headed by Prof. Thomas J. Vogl. Since 2013 she has been working in the fied of optical characterization of biological tissue, aiming to estimate optical properties of pancreas. She is collaborating with the team of Biophysics Institute J. W. Goethe Universität Frankfurt am Main, headed by Prof. Werner Mäntele. In the framework of laser ablation for the removal of pancreatic cancer, she has participated at the study approved by UCBM Ethics Committee -ComEt UCBM-, Prot. N. 4011/2011. The study aims to treat with laser ablation patients with inoperable pancreatic cancer. Since 2014 she is also involved in the design and development of tactile sensors for robotic artificial prosthetics

Research Interest: Military toxicology; Acetylcholinesterase reactivators as treatment of nerve agent and pesticide intoxications; Acetylcholinesterase inhibitors in Alzheimer´s disease and Myasthenia Gravis treatment; Synthesis of the detergents as disinfectants, decontamination means and environment for micellar catalysis; Drug design and Development; Chemical warfare agents; Biological warfare agents; Pharmaceutical Industry; Project Management; Scientific Management; Technology Transfer; Commercialization; Fund Raising; Cloud computing; Parallel computing; medical devices development; toxins. 

Research Interest: Biophotonics, BioMEMS, Optofluidics, Surface Wettability, Drug Delivery