Research Interest: Nano-Biomaterials Development, Cellular and Tissue Engineering Drug and Gene Delivery, Molecular Diagnostics Photobioreactor Design

Research Interest: Since 2008 Paola Saccomandi has been involved in research activities in the fields of biomedical instrumentations and measurements applied to medicine. From 2008 to 2011 she worked under the supervisio of Prof. Sergio Silvestri and Dr. Emiliano Schena in the fied of mechanical ventilation. In particular she worked on development of optoelectronic and fiber optic-based flow sensors, as well as on ventilatory gases humidification. In 2011 she started her main research activity in the field of laser ablation of cancer, with particular regard to pancreatic tumor. She developed a mathematic model aiming to predic effects of laser light o pancreas, in terms of ablated volume and temperature distribution. Since 2012 she has been investigating the field of invasive (fiber optic sensors, thermocouples) and non-ivasive (based on diagnostic images) thermometry for temperature monitoring during laser ablation of tumour. In this activity she is actively collaborating with the team of research of the Institute for Diagnostic and Interventional Radiology of J. W. Goethe Universität Frankfurt am Main, headed by Prof. Thomas J. Vogl. Since 2013 she has been working in the fied of optical characterization of biological tissue, aiming to estimate optical properties of pancreas. She is collaborating with the team of Biophysics Institute J. W. Goethe Universität Frankfurt am Main, headed by Prof. Werner Mäntele. In the framework of laser ablation for the removal of pancreatic cancer, she has participated at the study approved by UCBM Ethics Committee -ComEt UCBM-, Prot. N. 4011/2011. The study aims to treat with laser ablation patients with inoperable pancreatic cancer. Since 2014 she is also involved in the design and development of tactile sensors for robotic artificial prosthetics

Research Interest: Applied research specifically in tissue engineering, biomaterials and regenerative medicine. Currently focus is bionanomedicine, bionanocomposites and bionanotechnology

Research Interest:  His research interests concentrate on the biosensors (e.g. living cell sensor, DNA sensor and protein sensor) and BioMEMS system.

Research Interest:  Biomedical  instrumentation,  Health  monitoring  system,  System  modeling  and control, robotics

Research Interest: Scaffold Design For Tissue Engineering, Composites hydrogels For Bone Repair, Electrospinning and Electrospraying technology, Scanning and Trasmission Electron Microscopy, Image Analysis For Porosity Measurements, Chemical And Physical Properties Characterization Of Composite And/Or Polymeric Substrates, Injectable Composite Cements For Bone Cavity Filling.

Dr. Mohammed Rachidi received his PhD/ Doctorate Degree in Human and Molecular Genetics (with High Honors) at the prestigious ''Pasteur Institute'' (Paris, France), in the Department of Molecular and Cellular Genetics headed by the Professor François JACOB (Nobel Prize in Physiology/Medicine), where he studied the Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System development, CaMKinases & Biological Clock Function in Drosophila. Dr. Rachidi extended these Molecular Genetics works to Functional Genomics at Pasteur Institute and at Center National of Research Scientific CNRS and played key fundamental roles in different collaborative research projects with prestigious laboratories in Europe, Japan & United States. Remarkably, Dr. Rachidi collaborated with the Professor Michael ROSBASH (Nobel Prize in Physiology/Medicine 2017) in the Molecular Mechanisms of 2 genes involved in Circadian Clock.  Dr. Rachidi published with Professor ROSBASH this important work in the EMBO Journal Entitled : ''A New Gene encoding a putative Transcritpion Factor Regulated by the Drosophila Circadian Clock''. Postdoctoral training & Assistant Professor with Professor Nicole LeDOUARIN at the prestigious ''College De France'' & Institute of Cellular & Molecular Embryology (Paris), Dr. Rachidi studied some Chicken & Xenopus molecules acting in Bone Morphogenetic Protein BMP signaling pathways and identified their Mouse & Human homologs involved in differentiation of specific domains of neuronal progenitors, in cerebellum development and Joubert syndrome (a form of cerebellar ataxia). These experiences of Dr. Rachidi in the Molecular Genetics and in several Animal Models were extended to Human Molecular Genetics of Down syndrome (DS) & to Molecular and Cellular Mechanisms underlying Brain morphogenesis of Trisomic & Transgenic Mouse Models of DS and also of numerous stages of Embryonic & Fetal DS patients to elucidate the Neurogenetic Basis of Functional alterations Associated with Mental Retardation. Director of Research in Human Molecular Genetics, Faculty of Medicine University Paris 5 (France), with High Honours for Notable Scientific Research Contributions, Breakthroughs & Discoveries in Drosophila & Mouse & Human Molecular Genetics & Neurosciences, Dr. Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neuroscience & Biomedical Research. Dr. Rachidi realized numerous ''Discoveries and Innovations'' to name a few:  (1) - Discovery of Quantitative Assessment of Gene [removed]QAGE) as a New Method in situ detecting Differential Overexpression of Candidate Genes for Mental Retardation in Down syndrome Brain Regions & for Other Diseases caused by Regionalized Quantitative Transcriptional Alterations for greater interpretation of functional processes driving gene expression. (2) - Discovery of New Cerebellar & Cerebral Phenotypes in Transgenic mouse in vivo Library of Human Down syndrome Critical Region. (3) - Discovery of a Novel Light Microscopy Technology as Powerful Tool in Developmental Biology & Biomedical & Neuroscience Research. (4) - Discovery of New Genes involved in Brain Morphogenesis & in Visual System development; in Biological Clock; in Learning & Memory and in Mental Retardation in Down syndrome & Joubert syndrome. (5) - Discovery of the First Proposed Model of Molecular and Cellular Mechanism Elucidating Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Mental Retardation in Down syndrome: in this Model Gene Dosage Effects on transcriptional variations and the nature of gene products and their functional relationships are explained with the different aspects of neuronal differentiation. Dr. Rachidi published numerous articles in highly Prestigious International Journals with High Impact Factor like EMBO, Genomics, DNA Research, Gene, Mechanisms of Development, Cytogenetics & Genome Research, Neuroscience Research, International Journal of Developmental Neuroscience, Cell Tissue Research, American Journal of Intellectual Developmental Disability, European Journal of Paediatric Neurology...and in numerous journals of Elsevier & Springer. He has also authored numerous Chapters & Books. Dr. Rachidi has been honoured worldwide as Invited Distinguished Speaker, Chairman or Invited Honourable Organizing Committee Member in numerous International Conferences, Seminars & Workshops in Europe, USA & Asia. Dr Rachidi received numerous Awards & Honors and He is an Editor, Associate Editor, Executive Editor & Editor in Chief in numerous International peer-reviewed Journals.

Research Interest:

Dr. Mohammed Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neurosciences & Biomedical Research, to name a few : Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System, Biological Clock, Synaptic Protein Targeting, Synaptic Plasticity, CaMKII & CAMGUK/MAGUK, Learning and Memory. Functional Genomics & Mechanisms controlling Transposition at Cell Cycle. Transcription, Protein Translation & Virus-Like Particle Formation. Bone Morphogenetic Protein BMP signaling pathways, Mouse and Human Homeobox Genes, Cell Fate Determination and Differentiation, Neuronal Progenitors in Cerebellum development and Joubert syndrome. Trisomy 21, Intellectual Disability, Candidate Genes, Expression studies, Genotype-Phenotype Associations, Trisomic and Transgenic Mouse Models of Down syndrome, Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability.  Drosophila & Mouse & Human.

List of Publications:

- Rachidi, M. (2019). Pharmacotherapeutic Challenges for Rescuing Mental Retardation and Improving Brain Function in Down Syndrome.  Biophamaceutics and Therapeutic Challenges, 2019, (In Press).

- Rachidi, M. (2018). The Genetic Dosage Imbalance Linked to Clinical Brain Alterations and Mental Disability in Down syndrome could be Targeted for Therapeutics Development.
Medical Journal of Clinical Trials and Case studies. 2018, 2 (5): 000150.

- Rachidi, M. (2018). The Molecular Pathogenesis of Down Syndrome-Associated Diseases and the Promising Potential Therapeutic Targets.
Clinical and Medical Investigations, 2018, Vol. 3(1), 1-2.

- Rachidi, M. (2018). Trisomy of Chromosome 21 provides a Genetic Model for the Role of Aneuploidy in Cell Cycle Alterations, Leukemia, Tumors and Cancer   (In Press).

- Rachidi, M. (2016). Neurogenetic Disorders of Down Syndrome and Potential Pharmacotherapies for Mental Retardation.
American Journal of Clinical Neurology and Neurosurgery, 2016, Vol. 2, No. 4, 2016, pp. 45-49.

- Rachidi, M. (2015). Towards the Identification of Genetic Targets for Therapeutics of Intellectual Disability in Down syndrome.
J.J. Cenetics, 2015.

- Rachidi, M. and Lopes, C. (2013).  Mental Retardation and Human Chromosome 21 Gene Overdosage: From Functional Genomics and Molecular Mechanisms towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome.
Handbook of Neurochemistry and Molecular Neurobiology. In Genomics, Proteomics, and the Nervous System, Advances in Neurobiology, Springer Publishers 3rd Ed 2013.

- Rachidi M., Tetaria C., Lopes C. (2011). “Cell cycle alteration in Down syndrome”. In Berhardt LV. (Ed.), Advances in Medicine and Biology, 2011, Vol. 20. Nova Science Publisher.

- Rachidi, M. and Lopes, C. (2010). Molecular and Cellular Mechanisms Elucidating the Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability in Down syndrome.
American Journal of  Intellectual Developmental Disabilities, 2010; 115., 83-112.

- Rachidi, M. and Lopes, C. (2010). Cell Cycle Alteration in Down syndrome.
International Journal of Medical and Biological Frontiers, 2010, Volume 16, Issue 3/4,  Nova Science Publishers.

- Rachidi, M. and Lopes, C. (2009). Gene Expression Regulation in Down syndrome: Dosage Imbalance Effects at Transcriptome and Proteome Levels. Handbook of Down syndrome Research, Edition Nova Science Publishers, Inc., 2009, 55-87

- Rachidi, M., Delezoide, A-L., Delabar, J.M. and Lopes, C. (2009). A quantitative assessment of gene [removed]QAGE) reveals differential overexpression of DOPEY2, a candidate gene for mental retardation, in Down syndrome brain regions.
International Journal of Developmental Neuroscience, 2009, 27, 393-398.

- Rachidi, M., Tetaria, C., and Lopes, C. (2008). Trisomy of Human Chromosome 21 and Cell Cycle Control. In Leroy NH., Fournier NT. (Eds.): Cell Cycle Control: New Research, Nova Science Publishers, Inc., 2008, 159-189.

- Rachidi, M. and Lopes, C. (2008). Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways.
European Journal of Paediatric Neurology, 2008, 12, 168-182.

- Rachidi, M. and Lopes, C. (2008). Molecular Mechanisms of Mental Retardation in Down syndrome. Rachidi, M. and Lopes, C. (Editors), Nova Biomedical Book: Edition Nova Science Publishers, Inc., 2008, pp 1-94.

- Rachidi, M., Lopes, C.; C Vayssettes, D J. Smith, E M Rubin, J.M Delabar. (2007). New Cerebellar Phenotypes in YAC Transgenic mouse in vivo Library of Human Down syndrome Critical Region 1.
Biochemical Biophysical Research Communications, 2007, 364(3), 488-494.

- Rachidi, M. and Lopes, C. (2007). Molecular Mechanisms of Mental Retardation in Down Syndrome. In Carson MI. (Ed.): Focus on Mental Retardation Research. Nova Science Publishers, Inc. 2007, pp. 77-134.

- Rachidi, M. and Lopes, C. (2007). Mental retardation in Down syndrome: From gene dosage imbalance to molecular and cellular mechanisms.
Neuroscience Research, 2007, 59(4), 349-369.

- Rachidi, M. and Lopes, C. (2006). Differential transcription of Barhl1 homeobox gene in restricted functional domains of the central nervous system suggests a role in brain patterning.
International Journal of Developmental Neuroscience, 2006, 24(1), 35-44.

- Rachidi, M., Lopes, C., Delezoide, A.L. and Delabar, J.M. (2006). C21orf5, a human candidate gene for brain abnormalities and mental retardation in Down Syndrome.
Cytogenetics and Genome Research, 2006, 112(1-2), 16-22.

- Lopes, C., Delezoide, A.L., Delabar, J.M. and Rachidi, M. (2006). BARHL1 homeogene, the human ortholog of the mouse Barhl1 involved in cerebellum development, shows regional and cellular specificities in restricted domains of developing human central nervous system.
Biochemical Biophysical Research Communications, 2006, 339, 296-304.

- Rachidi, M., Lopes, C., Costantine, M. and Delabar J.M. (2005). C21orf5, a new member of dopey family involved in morphogenesis, could participate to neurological alterations and mental retardation in Down syndrome.
DNA Research, 2005, 12, 203-210.

- Rachidi, M., Lopes, C., Charron, G., Delezoide, AL., Paly, E., Bloch, B. and Delabar, JM. (2005). Spatial and temporal localization during embryonic and fetal human development of the transcription factor SIM2 in brain regions altered in Down syndrome.
International Journal of Developmental Neuroscience, 2005, 23, 475-484.

- Rachidi, M., Lopes, C., Benichou, J.C., Hellio, R. and Maisonhaute, C. (2005). Virus-like particle formation in Drosophila melanogaster germ cells suggests a complex translational regulation of the retrotransposon cycle and new mechanisms inhibiting transposition.
Cytogenetics and Genome Research, 2005, 111(1), 88-95.

- Lopes, C., Chettouh, Z., Delabar, J.M. and Rachidi, M. (2003). The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice. Biochemical Biophysical Research Communications, 2003, 305, 915-924.

- Takamatsu, Y., *Nakagoshi, H., *Rachidi, M., Lopes, C. Nishida, Y. and Ohsako, S. (2002). Characterization of the dCaMKII-GAL4 driver line whose expression is controlled by the. Drosophila Ca²+/calmodulin dependent protein kinase II promoter.
Cell Tissue Research., 2002, 310(2), 237-252.

- Lopes, C., Gassanova, S., Delabar, J.M. and Rachidi, M. (2001). The CASK/Lin-2 Drosophila Homologue, Camguk, Could Play a Role in Epithelial Patterning and in Neuronal Targeting.
Biochemical Biophysical Research Communications, 2001, 284(4), 1004-1010.

- Lopes, C., Rachidi, M., Charron, G., Chamoun, Z., Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B., Delezoide, A.L. and Delabar, JM. (2001). Conservation of the CNS expression pattern of new genes from the Down syndrome chromosomal region-1: human genes and their murine orthologs.
Cytogenetics and Cell Genetics, 2001, 92(1-2), 1-22.

- Rachidi, M., Lopes, C., Gassanova, S., Sinet, P.M., Vekemans, M., Attie, T., Delezoide, A.L. and Delabar, J.M. (2000). Regional and cellular specificity of TPRD, the tetratricopeptide Down Syndrome gene, during embryonic development.
Mechanisms of Development, 2000, 93(1-2), 189-193.

- Delabar, J.M., Rachidi, M., Lopes, C., Charron, G., Chamoun, Z, Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B. and Delezoide, A.L. (2000). Conservation of the CNS expression pattern of new genes from the Down Syndrome Chromosomal Region-1: Human genes and their Murine orthologs.
European Journal Neuroscience, 2000, 12(Supp 11), 297.

- Orti, R., Rachidi, M., Viallard, F., Toyama, K., Lopes, C., Taudien, S., Rosenthal, A., Sinet, P.M. and Delabar, J.M. (2000). Characterisation of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and its murine ortholog.
Genomics, 2000, 64(2), 203-210.

- Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1999). Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues.
European Journal of Human Genetics, 1999, 7(Supp.1), 111.

- Rachidi, M., Lopes, C., Takamatsu, Y., Ohsako, S., Benichou J.C. and Delabar, J.M. (1999). Dynamic expression pattern of Ca2+/calmodulin-dependent protein kinase II gene in the central nervous system of Drosophila throughout development.
Biochemical Biophysical Research Communications, 1999, 260(3), 707-711.

- Lopes, C., Rachidi, M., Gassanova, S., Sinet, P.M. and Delabar, J.M. (1999). Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1.
Mechanisms of Development, 1999, 84(1-2), 189-193.

- Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1998). Expression of the Mnb (dyrk) protein in adult and embryonic mouse tissues.
Biochemical Biophysical Research Communications,  1998, 253(2), 514-518.

- Rachidi, M., Lopes, C. and Benichou, J.C. (1997). Genetical analysis of visual system disorganizer (vid), a new gene involved in normal development of eye and optic lobe of the brain in Drosophila melanogaster. 
Genetica, 1997, 99, 31-45.

- Rachidi, M., Lopes, C., Benichou, J.C. and Rouyer, F. (1997). Analyse of period circadian expression in the Drosophila head by in situ hybridization. Journal of Neurogenetics, 1997, 11, 255-263.

- Rouyer, F., Rachidi, M., Pikielny, C. and Rosbash, M. (1997). A new gene encoding a putative transcritpion factor regulated by the Drosophila circadian clock.
EMBO Journal, 1997, 16(13), 3944-3954.

- Haoudi, A., Rachidi, M., Kim, M.H., Champion, S., Best-Belpomme, M. and Maisonhaute, C. (1997). Developmental expression analysis of the 1731 retrotransposon reveals an enhancement of Gag-Pol frameshifting in males of Drosophila melanogaster.
Gene, 1997, 196 (1-2), 83-93.

- Fassouane, A., Rachidi, M., Rouffaud, M.A., El-Abbouyi, A. and Nguyen, V.H. (1995). In vitro antifungal activity of Bacillus licheniformis FSJ-2 products against dermatophytes.
Journal of Mycology and Medicine, 1995, 5, 244-248.

- Rachidi, M. (1993). The Drosophila visual system: An elaborated building and a powerful model for developmental studies. Biomatec Journal, 1993, 4-5, 2-8.

Research Interest: His current research interests include non-linear analysis of biomedical time series, specially the analysis of electroencephalographic and magnetoencephalographic recordings to help physicians in the diagnosis of brain disorders

Research Interest: Medical Image Analysis and Processing  Computer Simulations of Nanoscale Systems  Communications and Mobile Computing  Bioinformatics and Computational Biology Computational Neuroscience and Vascular Flow Dynamics Biometrics and Bio-robotics Computer Aided Diagnosis and Guided Surgerya

Research Interest: Military toxicology; Acetylcholinesterase reactivators as treatment of nerve agent and pesticide intoxications; Acetylcholinesterase inhibitors in Alzheimer´s disease and Myasthenia Gravis treatment; Synthesis of the detergents as disinfectants, decontamination means and environment for micellar catalysis; Drug design and Development; Chemical warfare agents; Biological warfare agents; Pharmaceutical Industry; Project Management; Scientific Management; Technology Transfer; Commercialization; Fund Raising; Cloud computing; Parallel computing; medical devices development; toxins. 

Research Interest: Electromyography, muscle fatigue, motor units, innervation zone, anal sphincter, MMG, biofeedback, cervical kinematics, helical axis

Research Interest:  Non-point source, soil heavy metal, absorbing Material, and restoration

Research Interest: Bone and cartilage disease modeling, drug screening and gene correctionDirect differentiation of pluripotent stem cells toward cartilage and boneBone reprogramming of fibroblasts using defined factors Gene therapy for cartilage regeneration and repair in regenerative medicine Signaling pathway of genes regulating cartilage differentiation of human mesenchymal stem cells.Molecular basis of mesenchymal stem cells maintaining their stemness. Stem cell biology and technique

Publications List:

1. Liu TM*, Yingnan Wu. Editorial: Advancing Gene and Cell Therapy using Human Mesenchymal Stem Cells. Front Cell Dev Biol, 2023, 11:1294460. doi: 10.3389/fcell.2023.1294460. eCollection 2023. (IF 6.081, *corresponding author). Published on 13 Oct 2023.
2. Yufeng Shou, Ling Liu, Zhicheng Le, Khang Leng Lee, Xianlei Li, DionZhanyun Koh, Yuwen Wang, Tong Ming Liu, Zheng Yang, Chwee Teck Lim, Christine Cheung, Andy Tay. Mechano-responsive hydrogel for directing stem cell manufacturing and therapy. Bioact Mater, 2023, 24:387-400. doi: 10.1016/j.bioactmat.2022.12.019. eCollection 2023 Jun. eCollection 2023 Jun. (IF 16.44). (2023 Jan 2)
3. Liu TM*. Application of mesenchymal stem cells derived from human pluripotent stem cells in regenerative medicine. World J Stem cells, 2021,13(12): 1826-1844. doi: 10.4252/wjsc.v13.i12.1826  (Invited review, IF 5.326, *corresponding author). (2021 Dec 26)
4. Srinivasan A, Sathiyanathan P, Yin L, Liu TM, Lam A, Ravikumar M, Smith RAA, Loh HP, Zhang Y, Ling L, Ng SK, Yang YS, Lezhava A, Hui J, Oh S, Cool SM. Strategies to Enhance Immunomodulatory Properties and Reduce Heterogeneity in Mesenchymal Stromal Cells during ex vivo Expansion. Cytotherapy (IF 5.414). 2022 May;24(5):456-472. doi: 10.1016/j.jcyt.2021.11.009. Epub 2022 Feb 25. PMID: 35227601
5. Liu TM*, Yildirim ED, Li P, Fang HT, Denslin V, Kumar V, Loh YH, Lee EH, Cool SM, Teh BT, Hui JH, Lim B, Shyh-Chang N. Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells.  Stem Cell Reports, 2020, 14:210-225 (IF 7.765, *corresponding author, cited 7). doi: 10.1016/j.stemcr.2020.01.002. Epub 2020 Jan 30. 11 February 2020.
6. Liu TM*. Regulation of chondrogenesis. Ann Stem Cell Res Ther. 2019; 3(1): 1028. (Invited Editorial, *corresponding author).
7. Liu TM, Shyh-Chang N. SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nat Cell Biol. 2017 Apr 27; 19(5):412-414. doi: 10.1038/ncb3522 (IF 20.06, cited 12).
8. Liu TM*. Stemness of Mesenchymal Stem Cells. J Stem Cell Ther Transplant. 2017; 1: 071-073 (Invited Editorial, *corresponding author, cited 9).
9. Cheng H, Ang HY, A El Farran C, Li P, Fang HT, Liu TM, Kong SL, Chin ML, Ling WY, Lim EK, Li H, Huber T, Loh KM, Loh YH, Lim B. Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors. Nat. Commun. 2016 Nov 21; 7:13396. doi: 10.1038/ncomms13396 (IF 11.3, cited 17).
10. Liu TM*, Lee EH, Lim B, Shyh-Chang N. Balancing Stem Cell Self-renewal and Differentiation with PLZF. Stem cells, 2016 Feb; 34(2):277-87. doi: 10.1002/stem.2270. Epub 2016 Jan 5 (IF 7.133, *corresponding author, cited 54).
11. Liu TM*. Stem Cell-Based Therapies for Cartilage Repair and Regeneration. J Stem Cells Res, Rev &. Rep. 2014, 1(1): 1-2 (Invited Editorial, *corresponding author).
12. Tan HK, Toh CX, Ma D, Yang B, Liu TM, Lu J, Wong CW, Tan TK, Li H, Syn C, Tan EL, Lim B, Lim YP, Cook SA, Loh YH. Human Finger-Prick Induced Pluripotent Stem Cells Facilitate the Development of Stem Cell Banking. Stem Cells Transl Med. 2014 May; 3(5):586-98. doi: 10.5966/sctm.2013-0195. Epub 2014 Mar 19. (IF 5.709, cited 42)
13. Liu TM*, Lee EH. Transcriptional regulatory cascades in Runx2-dependent bone development. Tissue Eng Part B Rev, 2013, 19(3):254-63. doi: 10.1089/ten.TEB.2012.0527. (*corresponding author). (IF 4.448, cited 238)
14. Liu TM*, Ng WM, Tan HS, Vinitha D, Yang Z, Fan JB, Zou Y, Hui JH, Lee EH, Lim B. Molecular basis of immortalization of human mesenchymal stem cells by combination of p53 knockdown and human telomerase reverse transcriptase overexpression. Stem Cells Dev. 2013 Jan 15; 22(2):268-78. doi: 10.1089/scd.2012.0222. Epub 2012 Aug 21. (IF4.67, *corresponding author, cited 67).
15. Liu TM*. Gene therapy for articular cartilage repair. Pharmaceutica Analytica Acta, 2012,3:e1112. doi:10.4172/2153-2435.1000e112 (Invited Editorial, *Corresponding author).
16. Yang Z, Zou Y, Guo XM, Tan HS, Denslin V, Yeow CH, Ren XF, Liu TM, Hui JH, Lee EH. Temporal activation of ß-catenin signaling in the chondrogenic process of mesenchymal stem cells affects the phenotype of the cartilage generated. Stem Cells Dev. 2012, 21:1966-1976. 2011 Dec 1. [Epub ahead of print]. (IF4.791, cited 35).
17. Liu TM^*, Guo XM, Tan HS, Hui JH, Lim B, Lee EH. Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair. Arthritis Rheum. 2011 Sep; 63(9):2711-20. doi: 10.1002/art.30430. (IF8.435, *Corresponding author, cited 72).
18. Liu T, Liu L, Wei Q, Hong Y. Sperm nuclear transfer and transgenic production in the fish medaka. Int J Biol Sci, 2011, 7(4): 469-475. (IF 3.215, cited 22)
19. Liu TM, Wu YN, Guo XM, Hui JH, Lee EH, Lim B. Effects of ectopic Nanog and Oct4 overexpression on mesenchymal stem cells. Stem Cells Dev. 2009 Sep;18(7):1013-22. doi: 10.1089/scd.2008.0335. (IF4.45, cited 164)
20. Liu TM, Martina M, Hutmacher DW, Hui JH, Lee EH, Lim B. Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells. 2007 Mar;25(3):750-60. doi: 10.1634/stemcells.2006-0394. Epub 2006 Nov 9. (IF 7.751, cited 524)
21. Lian Q, Lye E, Suan Yeo K, Khia Way Tan E, Salto-Tellez M, Liu TM, Palanisamy N, El Oakley RM, Lee EH, Lim B, Lim SK. Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs. Stem Cells. 2007 Feb; 25(2):425-36. doi: 10.1634/stemcells.2006-0420. Epub 2006 Oct 19. (IF 7.751, cited 298).
22. Y.H. Hong, T.M. Liu, H.B. Zhao, H.Y. Xu, W.J. Wang, R. Liu, T.S. Chen. Establishment of a normal medakafish spermatogonial cell line capable of sperm production in vitro. Proc. Natl. Acad. Sci. USA., 2004, 101(21): 8011-8016. (IF 10.3, cited 213)
23. Y.H. Hong, C. Winkler, T.M. Liu, G.X. Chai, M. Schartl. Activation of the mouse Oct4 promoter in medaka embryonic stem cells and its use for ablation of spontaneous differentiation. Mech. Dev., 2004, 121: 933-943. (IF 3.16, cited 61)
24. TM Liu, QJ Wu, YZ Ye. Studies on the artificial induce gynogenesia and the sex revesal in loach (Misgurnus anguillicaudatus). Acta Hydrobiologica Sinica, 2004, 28: 445-447 (cited 6).
25. TM Liu, XM Yu, YZ Ye, JF Zhou, ZW Wang, JG Tong, QJ Wu. 2002. Factors affecting the efficiency of somatic cell nuclear transplantation in the fish embryo. The Journal of Experimental Zoology, 2002, 293:719-725 (cited 20)
26. T. M. Liu, Q. J. Wu, X. M. Yu, X.Y. Li. Effects of cell-cycle arrest agents on cleavage and development of loach (Misgurnus anguillicaudatus) embryos. Fish Physiology and Biochemistry, 2002, 25:3-9.
27. TM Liu, XM Yu, YZ Ye, ZW Wang, JF Zhou, QJ Wu. Studies on factors affecting the development of embryos from somatic cell nuclear transplantation in the fish. Zoological Research, 2002, 23(2): 107-112.
28. YD Liu, LR Song, XY Li, TM Liu. The toxic effects of microcystin-LR on embry-larval and juvenile development of loach, Misgurnus Mizolipis Gunthe. Toxicon, 2002, 40(4): 395-399 (cited 137).
29. TM Liu and QJ Wu. 2000. Progress of nuclear transplantation in teleost.   Biotechnology Information, 6:24-28.
30. TM Liu, JW Cao, LY Wan, Y Liu, YX Yu. Subcloning of alkalophilic gene from alkalophilic Bacillus sp. NTT36 and its expression in Escherichia coli and Agrobacterium tumefaciens. Amino Acids & Biotic Resources, 1999, 21(2): 37-40.
31. LY Wang, JW Cao, TM Liu, XQ Zhang. Cloning and expression of promoter from an alkalophilic Bacillus sp. NTT89 in Escherichia coli. Journal of Wuhan University (Natural Science Edition), 2000, 46(2): 257-260.
32. Y Gong, JW Cao, TM Liu. Clone and subclone of the alkalophilic gene from alkalophilic Bacillus sp. NTT36 and analysis of expressed products in E.coli. Journal of Wuhan University (Natural Science Edition), 1998, 44(6): 775-780.

Research Interest: Berber phonetics, Automatic Speech processing, Speech disorders Acoustic phonetics, Automatic Speech Recognition, Speech Synthesis, Artificial Neural NetworksArabic phonetics

Research Interest:  His research interests concentrate on the biosensors (e.g. living cell sensor, DNA sensor and protein sensor) and BioMEMS system.