Research Interest: Super-resolution technology; Stochastic Optical Reconstruction Microscopy(STORM); Cell Imaging and Structure; Propagation and Scattering of Light in Random and Complex Media; Classical Coherence Theory; Laser Communications and LaserRadar Systems; Near-field Scattering; Optical Imaging System

Research Interest: Cell and tissue engineering

Research Interest: Characterizing the mechanical properties and corrosion behaviour of biomaterials Mechanical surface treatments (shot peening and ball-burnishing) of metals and alloys. Coatings prior and after mechanical surface treatments. Evaluating the effects of Severe Plastic Deformations (SPD) on the materials. Characteristics Evaluation of surface layer properties (surface roughness, micro-hardness and residual stresses) of metals and alloys. Fatigue, corrosion fatigue and stress corrosion cracking of metals and alloys. Corrosion monitoring by electrochemical techniques. Analytical assessments by SEM and EDX. Analytical assessments by spectrophotometer and atomic absorption

Research Interest: Image / signal processing, Machine learning, Computer-aided clinical diagnosis and treatment selection

Research Interest: Design, fabrication, and optical properties of nanomaterials,- Biomedical applications (biosensing, bioimaging, therapy) of nanomaterials ,- Surface-enhanced Raman scattering and related biomedical applications

Research Interest: Connective Tissue, Drugs Action, Microscopy, Protein Modeling, Bone Structure, Trace/major Elements, Image Processing, Electromagnetism, Spectroscopy, Biometrics, Human Networks

Research Interest:  His research interests concentrate on the biosensors (e.g. living cell sensor, DNA sensor and protein sensor) and BioMEMS system.

Research Interest: Surgical planning and simulation in esthetical facial surgeryTelemedicine o Biomedical engineering 

Research Interest: His research focuses on computer assisted surgery, including medical image analysis, surgical navigation, surgery simulation, surgical robots, biomedical manufacturing, etc.

Research Interest: Biophotonics, BioMEMS, Optofluidics, Surface Wettability, Drug Delivery

Research Interest:  His research interests concentrate on the biosensors (e.g. living cell sensor, DNA sensor and protein sensor) and BioMEMS system.

Research Interest: Applied research specifically in tissue engineering, biomaterials and regenerative medicine. Currently focus is bionanomedicine, bionanocomposites and bionanotechnology

Research Interest: Developing inexpensive and portable optical technologies that can provide a rapid bedside assessment of brain function and health.

Research Interest: Bone and cartilage disease modeling, drug screening and gene correctionDirect differentiation of pluripotent stem cells toward cartilage and boneBone reprogramming of fibroblasts using defined factors Gene therapy for cartilage regeneration and repair in regenerative medicine Signaling pathway of genes regulating cartilage differentiation of human mesenchymal stem cells.Molecular basis of mesenchymal stem cells maintaining their stemness. Stem cell biology and technique

Publications List:

1. Liu TM*, Yingnan Wu. Editorial: Advancing Gene and Cell Therapy using Human Mesenchymal Stem Cells. Front Cell Dev Biol, 2023, 11:1294460. doi: 10.3389/fcell.2023.1294460. eCollection 2023. (IF 6.081, *corresponding author). Published on 13 Oct 2023.
2. Yufeng Shou, Ling Liu, Zhicheng Le, Khang Leng Lee, Xianlei Li, DionZhanyun Koh, Yuwen Wang, Tong Ming Liu, Zheng Yang, Chwee Teck Lim, Christine Cheung, Andy Tay. Mechano-responsive hydrogel for directing stem cell manufacturing and therapy. Bioact Mater, 2023, 24:387-400. doi: 10.1016/j.bioactmat.2022.12.019. eCollection 2023 Jun. eCollection 2023 Jun. (IF 16.44). (2023 Jan 2)
3. Liu TM*. Application of mesenchymal stem cells derived from human pluripotent stem cells in regenerative medicine. World J Stem cells, 2021,13(12): 1826-1844. doi: 10.4252/wjsc.v13.i12.1826  (Invited review, IF 5.326, *corresponding author). (2021 Dec 26)
4. Srinivasan A, Sathiyanathan P, Yin L, Liu TM, Lam A, Ravikumar M, Smith RAA, Loh HP, Zhang Y, Ling L, Ng SK, Yang YS, Lezhava A, Hui J, Oh S, Cool SM. Strategies to Enhance Immunomodulatory Properties and Reduce Heterogeneity in Mesenchymal Stromal Cells during ex vivo Expansion. Cytotherapy (IF 5.414). 2022 May;24(5):456-472. doi: 10.1016/j.jcyt.2021.11.009. Epub 2022 Feb 25. PMID: 35227601
5. Liu TM*, Yildirim ED, Li P, Fang HT, Denslin V, Kumar V, Loh YH, Lee EH, Cool SM, Teh BT, Hui JH, Lim B, Shyh-Chang N. Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells.  Stem Cell Reports, 2020, 14:210-225 (IF 7.765, *corresponding author, cited 7). doi: 10.1016/j.stemcr.2020.01.002. Epub 2020 Jan 30. 11 February 2020.
6. Liu TM*. Regulation of chondrogenesis. Ann Stem Cell Res Ther. 2019; 3(1): 1028. (Invited Editorial, *corresponding author).
7. Liu TM, Shyh-Chang N. SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nat Cell Biol. 2017 Apr 27; 19(5):412-414. doi: 10.1038/ncb3522 (IF 20.06, cited 12).
8. Liu TM*. Stemness of Mesenchymal Stem Cells. J Stem Cell Ther Transplant. 2017; 1: 071-073 (Invited Editorial, *corresponding author, cited 9).
9. Cheng H, Ang HY, A El Farran C, Li P, Fang HT, Liu TM, Kong SL, Chin ML, Ling WY, Lim EK, Li H, Huber T, Loh KM, Loh YH, Lim B. Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors. Nat. Commun. 2016 Nov 21; 7:13396. doi: 10.1038/ncomms13396 (IF 11.3, cited 17).
10. Liu TM*, Lee EH, Lim B, Shyh-Chang N. Balancing Stem Cell Self-renewal and Differentiation with PLZF. Stem cells, 2016 Feb; 34(2):277-87. doi: 10.1002/stem.2270. Epub 2016 Jan 5 (IF 7.133, *corresponding author, cited 54).
11. Liu TM*. Stem Cell-Based Therapies for Cartilage Repair and Regeneration. J Stem Cells Res, Rev &. Rep. 2014, 1(1): 1-2 (Invited Editorial, *corresponding author).
12. Tan HK, Toh CX, Ma D, Yang B, Liu TM, Lu J, Wong CW, Tan TK, Li H, Syn C, Tan EL, Lim B, Lim YP, Cook SA, Loh YH. Human Finger-Prick Induced Pluripotent Stem Cells Facilitate the Development of Stem Cell Banking. Stem Cells Transl Med. 2014 May; 3(5):586-98. doi: 10.5966/sctm.2013-0195. Epub 2014 Mar 19. (IF 5.709, cited 42)
13. Liu TM*, Lee EH. Transcriptional regulatory cascades in Runx2-dependent bone development. Tissue Eng Part B Rev, 2013, 19(3):254-63. doi: 10.1089/ten.TEB.2012.0527. (*corresponding author). (IF 4.448, cited 238)
14. Liu TM*, Ng WM, Tan HS, Vinitha D, Yang Z, Fan JB, Zou Y, Hui JH, Lee EH, Lim B. Molecular basis of immortalization of human mesenchymal stem cells by combination of p53 knockdown and human telomerase reverse transcriptase overexpression. Stem Cells Dev. 2013 Jan 15; 22(2):268-78. doi: 10.1089/scd.2012.0222. Epub 2012 Aug 21. (IF4.67, *corresponding author, cited 67).
15. Liu TM*. Gene therapy for articular cartilage repair. Pharmaceutica Analytica Acta, 2012,3:e1112. doi:10.4172/2153-2435.1000e112 (Invited Editorial, *Corresponding author).
16. Yang Z, Zou Y, Guo XM, Tan HS, Denslin V, Yeow CH, Ren XF, Liu TM, Hui JH, Lee EH. Temporal activation of ß-catenin signaling in the chondrogenic process of mesenchymal stem cells affects the phenotype of the cartilage generated. Stem Cells Dev. 2012, 21:1966-1976. 2011 Dec 1. [Epub ahead of print]. (IF4.791, cited 35).
17. Liu TM^*, Guo XM, Tan HS, Hui JH, Lim B, Lee EH. Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair. Arthritis Rheum. 2011 Sep; 63(9):2711-20. doi: 10.1002/art.30430. (IF8.435, *Corresponding author, cited 72).
18. Liu T, Liu L, Wei Q, Hong Y. Sperm nuclear transfer and transgenic production in the fish medaka. Int J Biol Sci, 2011, 7(4): 469-475. (IF 3.215, cited 22)
19. Liu TM, Wu YN, Guo XM, Hui JH, Lee EH, Lim B. Effects of ectopic Nanog and Oct4 overexpression on mesenchymal stem cells. Stem Cells Dev. 2009 Sep;18(7):1013-22. doi: 10.1089/scd.2008.0335. (IF4.45, cited 164)
20. Liu TM, Martina M, Hutmacher DW, Hui JH, Lee EH, Lim B. Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells. 2007 Mar;25(3):750-60. doi: 10.1634/stemcells.2006-0394. Epub 2006 Nov 9. (IF 7.751, cited 524)
21. Lian Q, Lye E, Suan Yeo K, Khia Way Tan E, Salto-Tellez M, Liu TM, Palanisamy N, El Oakley RM, Lee EH, Lim B, Lim SK. Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs. Stem Cells. 2007 Feb; 25(2):425-36. doi: 10.1634/stemcells.2006-0420. Epub 2006 Oct 19. (IF 7.751, cited 298).
22. Y.H. Hong, T.M. Liu, H.B. Zhao, H.Y. Xu, W.J. Wang, R. Liu, T.S. Chen. Establishment of a normal medakafish spermatogonial cell line capable of sperm production in vitro. Proc. Natl. Acad. Sci. USA., 2004, 101(21): 8011-8016. (IF 10.3, cited 213)
23. Y.H. Hong, C. Winkler, T.M. Liu, G.X. Chai, M. Schartl. Activation of the mouse Oct4 promoter in medaka embryonic stem cells and its use for ablation of spontaneous differentiation. Mech. Dev., 2004, 121: 933-943. (IF 3.16, cited 61)
24. TM Liu, QJ Wu, YZ Ye. Studies on the artificial induce gynogenesia and the sex revesal in loach (Misgurnus anguillicaudatus). Acta Hydrobiologica Sinica, 2004, 28: 445-447 (cited 6).
25. TM Liu, XM Yu, YZ Ye, JF Zhou, ZW Wang, JG Tong, QJ Wu. 2002. Factors affecting the efficiency of somatic cell nuclear transplantation in the fish embryo. The Journal of Experimental Zoology, 2002, 293:719-725 (cited 20)
26. T. M. Liu, Q. J. Wu, X. M. Yu, X.Y. Li. Effects of cell-cycle arrest agents on cleavage and development of loach (Misgurnus anguillicaudatus) embryos. Fish Physiology and Biochemistry, 2002, 25:3-9.
27. TM Liu, XM Yu, YZ Ye, ZW Wang, JF Zhou, QJ Wu. Studies on factors affecting the development of embryos from somatic cell nuclear transplantation in the fish. Zoological Research, 2002, 23(2): 107-112.
28. YD Liu, LR Song, XY Li, TM Liu. The toxic effects of microcystin-LR on embry-larval and juvenile development of loach, Misgurnus Mizolipis Gunthe. Toxicon, 2002, 40(4): 395-399 (cited 137).
29. TM Liu and QJ Wu. 2000. Progress of nuclear transplantation in teleost.   Biotechnology Information, 6:24-28.
30. TM Liu, JW Cao, LY Wan, Y Liu, YX Yu. Subcloning of alkalophilic gene from alkalophilic Bacillus sp. NTT36 and its expression in Escherichia coli and Agrobacterium tumefaciens. Amino Acids & Biotic Resources, 1999, 21(2): 37-40.
31. LY Wang, JW Cao, TM Liu, XQ Zhang. Cloning and expression of promoter from an alkalophilic Bacillus sp. NTT89 in Escherichia coli. Journal of Wuhan University (Natural Science Edition), 2000, 46(2): 257-260.
32. Y Gong, JW Cao, TM Liu. Clone and subclone of the alkalophilic gene from alkalophilic Bacillus sp. NTT36 and analysis of expressed products in E.coli. Journal of Wuhan University (Natural Science Edition), 1998, 44(6): 775-780.

Research Interest: Electroporation, Electroloading, Electrochemotherapy, Drug and Gene Delivery Systems, Molecular Imaging (EPR imaging; optical imaging; multimodal imaging – MRI/EPR, MRI/optical), Cancer Biochemistry