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    Editor-in-Chief

    Wei Min HUANG

    Wei Min HUANG
    Nanyang Technological University, Singapore
    Email: shape_memory_material@hotmail.com, mwmhuang@ntu.edu.sg
    Tel: 0065 84664500
    Fax: 0065 67924062
    Skype: shape_memory_material@hotmail.com

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    Executive Editors

    Carlo Massaroni
    School of Engineering
    Università Campus Bio-Medico di Roma
    Italy
    c.massaroni@unicampus.it
    ABSE

    Carlo Massaroni was born in Anzio (Rome) in 1988.

    He received the B.S. Degree in Biomedical Engineering from Università Campus Bio-Medico di Roma in December 2010. The Bachelor thesis title was "Perception Analysis of the form by the use of a numerical chessboard" and it was carried out in collaboration with the Bioinformatics Lab of the same University.

    He received the M.S. Degree  with highest honors in Biomedical Engineering from Università Campus Bio-Medico di Roma in December 2012. His graduation Thesis was entitled "Preliminary validation of a respiratory apparatus simulator for the assessment of metrological characteristics of a optoelectronic plethysmograph".

    With his thesis he won two relevant National Price. On September he has been awarded the 2013 SIAMOC Dissertation Prize by the Italian Society of Clinical Movement Analysis (SIAMOC) in recognition of the outstanding quality of his undergraduate research. On October he has been awarded the 2013 GNB Dissertation Price by the Italian National Bioengineering Group (GNB) for outstanding contribute in the field of Rehabilitation and Prosthetics.

    From April 2013 to January 2014 he worked as Biomechanical Researcher in the Unit of Rehabilitation at Scientific Institute for Research IRCCS Eugenio Medea of Conegliano (TV), as Scholarship Winner and Assignee for 2013.

    He was PhD Student in Biomedical Engineering at Università Campus Bio-Medico di Roma from January 2014 to December 2016: he started working in the Laboratory of Measurements and Biomedical Instrumentation in January 2014, under the supervision of Prof. Sergio Silvestri.

    In 2014 he has achieved the Professional Qualification as Industrial Engineer (Section A). He was Jury Aggregate Member as Topic expert in Biomedical Instrumentation during the State Examinations enabling the exercise of the profession of Engineer on behalf of Ordine degli Ingegneri of Rome. Section A - Industrial Section.

    From February 2015 is Student Mentor for the International Biomechanics Society (ISB) in Instrumentation for Human Motion, Optoelectronic Systems and Optoelectronic Plethysmography.  

    On July 2015 he has been awarded the International Grant Travel Program Award by the International Society of Biomechanics (ISB) with the project "MoCBA - MOtion Capture for Breathing Assessment". MoCBA is an interdisciplinary project taking advantage of the research cooperation between the School of Sport & Exercise Sciences (SSES) at the University of Kent (Dr. Dickinson and Dr. Winter) and the School of Engineering, Research Unit of Measurement and Biomedical Instrumentation (UCBM) at the Campus Bio-Medico di Roma University. He is currently (until 22/04/2016) a Visiting PhD Student  at University of Kent (Medway Campus, Kent, UK), where he is working in the Respiratory Clinic Unit.

    On September 2017 he has been awarded the 2017 GNB Thesis Award by the Italian National Bioengineering Group (GNB) for outstanding contribute in the field of Biorobotics and Biomechanics.

    URL: http://mtmbilaben.weebly.com/carlo-massaroni.html

    Grant Details:

    2017 IEEE Sensor Council Travel Award (€ 1000) to attend the 2nd IEEE Sensors Summer
    School on Optical Fibre Sensors at the University of Limerick, Ireland. 26th – 30th
    June 2017 - Limerick, Ireland.
    2016 European Society of Biomechanics (ESB) Travel Award (€ 400) to attend the 22nd
    Congress of the European Society of Biomechanics (Respiratory Biomechanics
    Session) - Lyon, France.
    2015 International Society of Biomechanics (ISB) International Travel Grant (ITG2015) ($
    2500) to fund the Research Project “MoCBA: Motion Capture for Breathing
    Assessment” and to fund the foreign period of 6 months at University of Kent (UK).

    Number of Publications: 43 </xml> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0in; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-ansi-language:EN-IN;} </style> List of Publications: 43

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    Editorial Board

    Francesco D Angelo
    Angeglantoni Life Science
    Italy
    francescodangelo@hotmail.it
    ABSE

    Research Interest: Stem cells and Regenerative Medicine, Tissue Regeneration, Tissue Engineering Stem Cells Biology and Differentiation, Stem cells biomaterials interaction, Mechanotransduction

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    Herng-Hua Chang
    Assistant Professor
    Department of Engineering Science & Ocean Engineering
    National Taiwan University
    Taiwan
    herbertchang@ntu.edu.tw
    ABSE

    Research Interest: Medical Image Analysis and Processing  Computer Simulations of Nanoscale Systems  Communications and Mobile Computing  Bioinformatics and Computational Biology Computational Neuroscience and Vascular Flow Dynamics Biometrics and Bio-robotics Computer Aided Diagnosis and Guided Surgerya

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    Yan Xie
    Queensland University of Technology
    Australia
    y2.xie@qut.edu.au
    ABSE

    Research Interest: Tissue & organ repair and regeneration, Tissue engineering, Wound healing, Clinical medicine, dimensional tissue equivalent models, Novel wound and scar remediation therapies, Chinese herbal medicine, Growth factor/extracellular matrix protein complexes, Pharmaceutical and drugs

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    Mohammed Rachidi
    Doctor
    Department of Sciences
    University Paris Diderot, Paris
    France
    rachidi.med1@yahoo.com
    ABSE

    Dr. Mohammed Rachidi received his PhD/ Doctorate Degree in Human and Molecular Genetics (with High Honors) at the prestigious ''Pasteur Institute'' (Paris, France), in the Department of Molecular and Cellular Genetics headed by the Professor François JACOB (Nobel Prize in Physiology/Medicine), where he studied the Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System development, CaMKinases & Biological Clock Function in Drosophila. Dr. Rachidi extended these Molecular Genetics works to Functional Genomics at Pasteur Institute and at Center National of Research Scientific CNRS and played key fundamental roles in different collaborative research projects with prestigious laboratories in Europe, Japan & United States. Remarkably, Dr. Rachidi collaborated with the Professor Michael ROSBASH (Nobel Prize in Physiology/Medicine 2017) in the Molecular Mechanisms of 2 genes involved in Circadian Clock.  Dr. Rachidi published with Professor ROSBASH this important work in the EMBO Journal Entitled : ''A New Gene encoding a putative Transcritpion Factor Regulated by the Drosophila Circadian Clock''. Postdoctoral training & Assistant Professor with Professor Nicole LeDOUARIN at the prestigious ''College De France'' & Institute of Cellular & Molecular Embryology (Paris), Dr. Rachidi studied some Chicken & Xenopus molecules acting in Bone Morphogenetic Protein BMP signaling pathways and identified their Mouse & Human homologs involved in differentiation of specific domains of neuronal progenitors, in cerebellum development and Joubert syndrome (a form of cerebellar ataxia). These experiences of Dr. Rachidi in the Molecular Genetics and in several Animal Models were extended to Human Molecular Genetics of Down syndrome (DS) & to Molecular and Cellular Mechanisms underlying Brain morphogenesis of Trisomic & Transgenic Mouse Models of DS and also of numerous stages of Embryonic & Fetal DS patients to elucidate the Neurogenetic Basis of Functional alterations Associated with Mental Retardation. Director of Research in Human Molecular Genetics, Faculty of Medicine University Paris 5 (France), with High Honours for Notable Scientific Research Contributions, Breakthroughs & Discoveries in Drosophila & Mouse & Human Molecular Genetics & Neurosciences, Dr. Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neuroscience & Biomedical Research. Dr. Rachidi realized numerous ''Discoveries and Innovations'' to name a few:  (1) - Discovery of Quantitative Assessment of Gene [removed]QAGE) as a New Method in situ detecting Differential Overexpression of Candidate Genes for Mental Retardation in Down syndrome Brain Regions & for Other Diseases caused by Regionalized Quantitative Transcriptional Alterations for greater interpretation of functional processes driving gene expression. (2) - Discovery of New Cerebellar & Cerebral Phenotypes in Transgenic mouse in vivo Library of Human Down syndrome Critical Region. (3) - Discovery of a Novel Light Microscopy Technology as Powerful Tool in Developmental Biology & Biomedical & Neuroscience Research. (4) - Discovery of New Genes involved in Brain Morphogenesis & in Visual System development; in Biological Clock; in Learning & Memory and in Mental Retardation in Down syndrome & Joubert syndrome. (5) - Discovery of the First Proposed Model of Molecular and Cellular Mechanism Elucidating Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Mental Retardation in Down syndrome: in this Model Gene Dosage Effects on transcriptional variations and the nature of gene products and their functional relationships are explained with the different aspects of neuronal differentiation. Dr. Rachidi published numerous articles in highly Prestigious International Journals with High Impact Factor like EMBO, Genomics, DNA Research, Gene, Mechanisms of Development, Cytogenetics & Genome Research, Neuroscience Research, International Journal of Developmental Neuroscience, Cell Tissue Research, American Journal of Intellectual Developmental Disability, European Journal of Paediatric Neurology...and in numerous journals of Elsevier & Springer. He has also authored numerous Chapters & Books. Dr. Rachidi has been honoured worldwide as Invited Distinguished Speaker, Chairman or Invited Honourable Organizing Committee Member in numerous International Conferences, Seminars & Workshops in Europe, USA & Asia. Dr Rachidi received numerous Awards & Honors and He is an Editor, Associate Editor, Executive Editor & Editor in Chief in numerous International peer-reviewed Journals.

    Research Interest:

    Dr. Mohammed Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neurosciences & Biomedical Research, to name a few : Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System, Biological Clock, Synaptic Protein Targeting, Synaptic Plasticity, CaMKII & CAMGUK/MAGUK, Learning and Memory. Functional Genomics & Mechanisms controlling Transposition at Cell Cycle. Transcription, Protein Translation & Virus-Like Particle Formation. Bone Morphogenetic Protein BMP signaling pathways, Mouse and Human Homeobox Genes, Cell Fate Determination and Differentiation, Neuronal Progenitors in Cerebellum development and Joubert syndrome. Trisomy 21, Intellectual Disability, Candidate Genes, Expression studies, Genotype-Phenotype Associations, Trisomic and Transgenic Mouse Models of Down syndrome, Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability.  Drosophila & Mouse & Human.

    List of Publications:

    - Rachidi, M. (2019). Pharmacotherapeutic Challenges for Rescuing Mental Retardation and Improving Brain Function in Down Syndrome.  Biophamaceutics and Therapeutic Challenges, 2019, (In Press).

    - Rachidi, M. (2018). The Genetic Dosage Imbalance Linked to Clinical Brain Alterations and Mental Disability in Down syndrome could be Targeted for Therapeutics Development.
    Medical Journal of Clinical Trials and Case studies. 2018, 2 (5): 000150.

    - Rachidi, M. (2018). The Molecular Pathogenesis of Down Syndrome-Associated Diseases and the Promising Potential Therapeutic Targets.
    Clinical and Medical Investigations, 2018, Vol. 3(1), 1-2.

    - Rachidi, M. (2018). Trisomy of Chromosome 21 provides a Genetic Model for the Role of Aneuploidy in Cell Cycle Alterations, Leukemia, Tumors and Cancer   (In Press).

    - Rachidi, M. (2016). Neurogenetic Disorders of Down Syndrome and Potential Pharmacotherapies for Mental Retardation.
    American Journal of Clinical Neurology and Neurosurgery, 2016, Vol. 2, No. 4, 2016, pp. 45-49.

    - Rachidi, M. (2015). Towards the Identification of Genetic Targets for Therapeutics of Intellectual Disability in Down syndrome.
    J.J. Cenetics, 2015.

    - Rachidi, M. and Lopes, C. (2013).  Mental Retardation and Human Chromosome 21 Gene Overdosage: From Functional Genomics and Molecular Mechanisms towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome.
    Handbook of Neurochemistry and Molecular Neurobiology. In Genomics, Proteomics, and the Nervous System, Advances in Neurobiology, Springer Publishers 3rd Ed 2013.

    - Rachidi M., Tetaria C., Lopes C. (2011). “Cell cycle alteration in Down syndrome”. In Berhardt LV. (Ed.), Advances in Medicine and Biology, 2011, Vol. 20. Nova Science Publisher.

    - Rachidi, M. and Lopes, C. (2010). Molecular and Cellular Mechanisms Elucidating the Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability in Down syndrome.
    American Journal of  Intellectual Developmental Disabilities, 2010; 115., 83-112.

    - Rachidi, M. and Lopes, C. (2010). Cell Cycle Alteration in Down syndrome.
    International Journal of Medical and Biological Frontiers, 2010, Volume 16, Issue 3/4,  Nova Science Publishers.

    - Rachidi, M. and Lopes, C. (2009). Gene Expression Regulation in Down syndrome: Dosage Imbalance Effects at Transcriptome and Proteome Levels. Handbook of Down syndrome Research, Edition Nova Science Publishers, Inc., 2009, 55-87

    - Rachidi, M., Delezoide, A-L., Delabar, J.M. and Lopes, C. (2009). A quantitative assessment of gene [removed]QAGE) reveals differential overexpression of DOPEY2, a candidate gene for mental retardation, in Down syndrome brain regions.
    International Journal of Developmental Neuroscience, 2009, 27, 393-398.

    - Rachidi, M., Tetaria, C., and Lopes, C. (2008). Trisomy of Human Chromosome 21 and Cell Cycle Control. In Leroy NH., Fournier NT. (Eds.): Cell Cycle Control: New Research, Nova Science Publishers, Inc., 2008, 159-189.

    - Rachidi, M. and Lopes, C. (2008). Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways.
    European Journal of Paediatric Neurology, 2008, 12, 168-182.

    - Rachidi, M. and Lopes, C. (2008). Molecular Mechanisms of Mental Retardation in Down syndrome. Rachidi, M. and Lopes, C. (Editors), Nova Biomedical Book: Edition Nova Science Publishers, Inc., 2008, pp 1-94.

    - Rachidi, M., Lopes, C.; C Vayssettes, D J. Smith, E M Rubin, J.M Delabar. (2007). New Cerebellar Phenotypes in YAC Transgenic mouse in vivo Library of Human Down syndrome Critical Region 1.
    Biochemical Biophysical Research Communications, 2007, 364(3), 488-494.

    - Rachidi, M. and Lopes, C. (2007). Molecular Mechanisms of Mental Retardation in Down Syndrome. In Carson MI. (Ed.): Focus on Mental Retardation Research. Nova Science Publishers, Inc. 2007, pp. 77-134.

    - Rachidi, M. and Lopes, C. (2007). Mental retardation in Down syndrome: From gene dosage imbalance to molecular and cellular mechanisms.
    Neuroscience Research, 2007, 59(4), 349-369.

    - Rachidi, M. and Lopes, C. (2006). Differential transcription of Barhl1 homeobox gene in restricted functional domains of the central nervous system suggests a role in brain patterning.
    International Journal of Developmental Neuroscience, 2006, 24(1), 35-44.

    - Rachidi, M., Lopes, C., Delezoide, A.L. and Delabar, J.M. (2006). C21orf5, a human candidate gene for brain abnormalities and mental retardation in Down Syndrome.
    Cytogenetics and Genome Research, 2006, 112(1-2), 16-22.

    - Lopes, C., Delezoide, A.L., Delabar, J.M. and Rachidi, M. (2006). BARHL1 homeogene, the human ortholog of the mouse Barhl1 involved in cerebellum development, shows regional and cellular specificities in restricted domains of developing human central nervous system.
    Biochemical Biophysical Research Communications, 2006, 339, 296-304.

    - Rachidi, M., Lopes, C., Costantine, M. and Delabar J.M. (2005). C21orf5, a new member of dopey family involved in morphogenesis, could participate to neurological alterations and mental retardation in Down syndrome.
    DNA Research, 2005, 12, 203-210.

    - Rachidi, M., Lopes, C., Charron, G., Delezoide, AL., Paly, E., Bloch, B. and Delabar, JM. (2005). Spatial and temporal localization during embryonic and fetal human development of the transcription factor SIM2 in brain regions altered in Down syndrome.
    International Journal of Developmental Neuroscience, 2005, 23, 475-484.

    - Rachidi, M., Lopes, C., Benichou, J.C., Hellio, R. and Maisonhaute, C. (2005). Virus-like particle formation in Drosophila melanogaster germ cells suggests a complex translational regulation of the retrotransposon cycle and new mechanisms inhibiting transposition.
    Cytogenetics and Genome Research, 2005, 111(1), 88-95.

    - Lopes, C., Chettouh, Z., Delabar, J.M. and Rachidi, M. (2003). The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice. Biochemical Biophysical Research Communications, 2003, 305, 915-924.

    - Takamatsu, Y., *Nakagoshi, H., *Rachidi, M., Lopes, C. Nishida, Y. and Ohsako, S. (2002). Characterization of the dCaMKII-GAL4 driver line whose expression is controlled by the. Drosophila Ca²+/calmodulin dependent protein kinase II promoter.
    Cell Tissue Research., 2002, 310(2), 237-252.

    - Lopes, C., Gassanova, S., Delabar, J.M. and Rachidi, M. (2001). The CASK/Lin-2 Drosophila Homologue, Camguk, Could Play a Role in Epithelial Patterning and in Neuronal Targeting.
    Biochemical Biophysical Research Communications, 2001, 284(4), 1004-1010.

    - Lopes, C., Rachidi, M., Charron, G., Chamoun, Z., Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B., Delezoide, A.L. and Delabar, JM. (2001). Conservation of the CNS expression pattern of new genes from the Down syndrome chromosomal region-1: human genes and their murine orthologs.
    Cytogenetics and Cell Genetics, 2001, 92(1-2), 1-22.

    - Rachidi, M., Lopes, C., Gassanova, S., Sinet, P.M., Vekemans, M., Attie, T., Delezoide, A.L. and Delabar, J.M. (2000). Regional and cellular specificity of TPRD, the tetratricopeptide Down Syndrome gene, during embryonic development.
    Mechanisms of Development, 2000, 93(1-2), 189-193.

    - Delabar, J.M., Rachidi, M., Lopes, C., Charron, G., Chamoun, Z, Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B. and Delezoide, A.L. (2000). Conservation of the CNS expression pattern of new genes from the Down Syndrome Chromosomal Region-1: Human genes and their Murine orthologs.
    European Journal Neuroscience, 2000, 12(Supp 11), 297.

    - Orti, R., Rachidi, M., Viallard, F., Toyama, K., Lopes, C., Taudien, S., Rosenthal, A., Sinet, P.M. and Delabar, J.M. (2000). Characterisation of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and its murine ortholog.
    Genomics, 2000, 64(2), 203-210.

    - Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1999). Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues.
    European Journal of Human Genetics, 1999, 7(Supp.1), 111.

    - Rachidi, M., Lopes, C., Takamatsu, Y., Ohsako, S., Benichou J.C. and Delabar, J.M. (1999). Dynamic expression pattern of Ca2+/calmodulin-dependent protein kinase II gene in the central nervous system of Drosophila throughout development.
    Biochemical Biophysical Research Communications, 1999, 260(3), 707-711.

    - Lopes, C., Rachidi, M., Gassanova, S., Sinet, P.M. and Delabar, J.M. (1999). Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1.
    Mechanisms of Development, 1999, 84(1-2), 189-193.

    - Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1998). Expression of the Mnb (dyrk) protein in adult and embryonic mouse tissues.
    Biochemical Biophysical Research Communications,  1998, 253(2), 514-518.

    - Rachidi, M., Lopes, C. and Benichou, J.C. (1997). Genetical analysis of visual system disorganizer (vid), a new gene involved in normal development of eye and optic lobe of the brain in Drosophila melanogaster. 
    Genetica, 1997, 99, 31-45.

    - Rachidi, M., Lopes, C., Benichou, J.C. and Rouyer, F. (1997). Analyse of period circadian expression in the Drosophila head by in situ hybridization. Journal of Neurogenetics, 1997, 11, 255-263.

    - Rouyer, F., Rachidi, M., Pikielny, C. and Rosbash, M. (1997). A new gene encoding a putative transcritpion factor regulated by the Drosophila circadian clock.
    EMBO Journal, 1997, 16(13), 3944-3954.

    - Haoudi, A., Rachidi, M., Kim, M.H., Champion, S., Best-Belpomme, M. and Maisonhaute, C. (1997). Developmental expression analysis of the 1731 retrotransposon reveals an enhancement of Gag-Pol frameshifting in males of Drosophila melanogaster.
    Gene, 1997, 196 (1-2), 83-93.

    - Fassouane, A., Rachidi, M., Rouffaud, M.A., El-Abbouyi, A. and Nguyen, V.H. (1995). In vitro antifungal activity of Bacillus licheniformis FSJ-2 products against dermatophytes.
    Journal of Mycology and Medicine, 1995, 5, 244-248.

    - Rachidi, M. (1993). The Drosophila visual system: An elaborated building and a powerful model for developmental studies. Biomatec Journal, 1993, 4-5, 2-8.

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    Margaret Tzaphlidou
    Professor
    Department of Medical Physics
    University of Ioannina
    Greece
    mtzaphli@uoi.gr
    ABSE

    Research Interest: Connective Tissue, Drugs Action, Microscopy, Protein Modeling, Bone Structure, Trace/major Elements, Image Processing, Electromagnetism, Spectroscopy, Biometrics, Human Networks

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    Biliana Pancheva Nikolova
    Associate Professor
    Institute of Biophysics & Biomedical Engineering
    Bulgaria
    nikolova@bio21.bas.bg
    ABSE

    Research Interest: Electroporation, Electroloading, Electrochemotherapy, Drug and Gene Delivery Systems, Molecular Imaging (EPR imaging; optical imaging; multimodal imaging – MRI/EPR, MRI/optical), Cancer Biochemistry

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    Shibsekhar Roy
    Waterford Institute of Technology
    ireland
    shibsekharroy@gmail.com
    ABSE

    Research Interest: Biophotonics and Biosensors

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    Weihua Qiao
    Associate Professor
    Department of Cardiovascular Surgery, Union Hospital
    Tongji Medical College, Huazhong University of Science and Technology
    China
    Weihua_qiao@hust.edu.cn
    ABSE

    Weihua Qiao, MD, PhD, is a Cardiovascular Surgeon and Associate Professor of Surgery at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Dr. Qiao earned his medical degree from Chongqing Medical University in 2011. He obtained his PhD in the Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology with Dr. Nianguo Dong in 2016. His clinical interests include complex congenital cardiac surgery, minimally invasive cardiac surgery, and cardiac transplantation. Dr. Qiao serves as Principal Investigator on grants funded by National Key Research and Development Plan of China, National Natural Science Foundation of China, and other national/funding resources. His research is focused on biomedical materials and cardiovascular tissue engineering. Dr. Qiao has published more than 40 peer-review research papers including Circulation, European Heart Journal, Advanced Functional Materials and Acta Biomaterialia, and filed more than 10 patents. He has served as an editorial member and peer reviewer for several scientific journals in cardiovascular research and biomaterials. He has also served as mentor or advisor for a number of postdoctoral fellows, medical students, graduate and undergraduate students.

    Research Interest: Biomedical materials and cardiovascular tissue engineering.

    Publication List:

    1. Ziwen Cai#, Miaomiao Zhu#, Li Xu#, Yue Wang, Yin Xu, Wai Yen Yim, Hong Cao, Ruikang Guo, Xiang Qiu, Ximiao He, Jiawei Shi, Weihua Qiao* and Nianguo Dong*. Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells. Circulation. 2024. DOI: 10.1161/CIRCULATIONAHA.123.065143. (Co-corresponding author).
    2. Shijie Wang, Weihua Qiao*, Nianguo Dong*. Residual shunt and microthrombosis associated with new-onset migraine after transcatheter atrial septal defect closure. European Heart Journal. 2023, 44(43): 4605-4605. (Co-corresponding author).
    3. Ying Zhou#, Ge Yan#, Shuyu Wen, Wai Yen Yim, Zihao Wang, Xing Chen, Yin Xu, Xue Chen, Hong Cao, Peng Bai, Fei Li, Jiawei Shi, Jianglin Wang, Weihua Qiao*, Nianguo Dong*. Nitric Oxide Generation and Endothelial Progenitor Cells Recruitment for Improving Hemocompatibility and Accelerating Endothelialization of Tissue Engineering Heart Valve. Advanced Functional Materials. 2023, 33(9): 2211267. (Co-corresponding author).
    4. Hong Cao#, Qian Zhou#, Chungeng Liu, Yecen Zhang, Minghui Xie, Weihua Qiao*, Nianguo Dong*. Substrate stiffness regulates differentiation of induced pluripotent stem cells into heart valve endothelial cells. Acta Biomaterialia. 2022, 143: 115-126. (Co-corresponding author).
    5. Xing Chen, Yunlong Wu, Rui Li, Chenghao Li, Li Xu*, Weihua Qiao*, Nianguo Dong*. Galactose-modified nanoparticles for delivery of microRNA to mitigate the progress of abdominal aortic aneurysms via regulating macrophage polarization. Nanomedicine: Nanotechnology, Biology and Medicine. 2022, 44: 102564. (Co-corresponding author).
    6. Shuangshuang Zhu#, Yanting Zhang#, Weihua Qiao#, Yixuan Wang, Yuji Xie, Xin Zhang, Chun Wu, Guohua Wan4, Yuman Li, Nianguo Dong*, Mingxing Xie*, Li Zhang*. Incremental value of preoperative right ventricular function in predicting moderate to severe acute kidney injury after heart transplantation. Frontiers in cardiovascular medicine. 2022, 9: 931517. (Co-first author).
    7. Xing Chen#, Wei-hua Qiao#, Hong Cao#, Jia-wei Shi, Xin-ling Du*, Nian-guo Dong*. Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage. Current Medical Science. 2022, 42(3): 555-560. (Co-first author).
    8. Shuyu Wen#, Ying Zhou#, Wai Yen Yim, Shijie Wang, Li Xu, Jiawei Shi, Weihua Qiao*, Nianguo Dong*. Mechanisms and Drug Therapies of Bioprosthetic Heart Valve Calcification. Frontiers in Pharmacology. 2022, 13: 909801. (Co-corresponding author).
    9. Ge Yan, Yuqi Liu, Minghui Xie, Jiawei Shi, Weihua Qiao*, Nianguo Dong*. Experimental and computational models for tissue-engineered heart valves: a narrative review. Biomaterials Translational. 2021; 2(4): 361–375. (Co-corresponding author).
    10. Baocheng Zhang#, Yuan Xu#, Sitian Ma, Linfeng Wang, Changjun Liu, Weilin Xu, Jiawei Shi, Weihua Qiao*, Hongjun Yang*. Small-diameter polyurethane vascular graft with high strength and excellent compliance            . Journal of the Mechanical Behavior of Biomedical Materials. 2021, 121: 104614. (Co-corresponding author).
    11. Changjun Liu#, Weihua Qiao#, Chaorong Wang, Han Wang, Yingshan Zhou, Shaojin Gua, Weilin Xu, Yan Zhuang, Jiawei Shi*, Hongjun Yang*. Effect of poly (lactic acid) porous membrane prepared via phase inversion induced by water droplets on 3T3 cell behavior. International Journal of Biological Macromolecules. 2021, 183: 2205-2214. (Co-first author).
    12. Chungeng Liu#, Weihua Qiao#, Hong Cao, Jinchi Dai, Fei Li, Jiawei Shi* and Nianguo Dong*. A riboflavin–ultraviolet light A-crosslinked decellularized heart valve for improved biomechanical properties, stability, and biocompatibility. Biomaterials Science. 2020, 8(9): 2549-2563. (Co-first author).
    13. Han Wang#, Weihua Qiao#, Sitian Ma, Linfeng Wang, Changjun Liu, Yingshan Zhou, Shaojin Gu, Weilin Xu, Jiawei Shi*, Hongjun Yang*. Effect of temperature on the thermal property and crystallization behavior of poly (lactic acid) porous membrane prepared via phase separation induced by water microdroplets. International Journal of Biological Macromolecules. 2020, 147: 1185-1192. (Co-first author).
    14. Shuyu Wen#, Weihua Qiao#, Yuan Zhang, and Nianguo Dong*. Development and trend in the field of valvular heart disease in China: an analysis based on the National Natural Science Foundation of China. Annals of Translational Medicine, 2020, 8(7): 449. (Co-first author).
    15. Jinchi Dai#, Weihua Qiao#, Jiawei Shi, Chungen Liu, Xingjian Hu, Nianguo Dong. Modifying Decellularized Aortic Valve Scaffolds with Stromal Cell-derived Factor-1α Loaded Proteolytically Degradable Hydrogel for Recellularization and Remodeling. Acta Biomaterialia, 2019, 88: 280-292. (Co-first author).
    16. Wei-hua Qiao#, Peng Liu, Dan Hu, Mahmoud Al Shirbini, Xian-ming Zhou, Nian-guo Dong*. Sequential hydrophile and lipophile solubilization as an efficient method for decellularization of porcine aortic valve: structure, mechanical property and biocompatibility study. Journal of Tissue Engineering and Regenerative Medicine. 2018, 12(2): e828-e840.
    17. Geng Li#, Weihua Qiao#, Wenjing Zhang, Fei Li, Jiawei Shi, Nianguo Dong*. The shift of macrophages toward M1 phenotype promotes aortic valvular calcification. Journal of Thoracic and Cardiovascular Surgery. 2017, 153(6): 1318-1327. e1. (Co-first author).
    18. Peng Liu#, Wei-Hua Qiao#, Fu-Qiang Sun, Xin-Long Ruan, Mahmoud Al Shirbini, Dan Hu, Si Chen, Nian-Guo Dong*. Should a Mechanical or Biological Prosthesis Be Used for a Tricuspid Valve Replacement? A Meta-Analysis. Journal of Cardiac Surgery. 2016, 31(5): 294-302. (Co-first author).
    19. Weihua Qiao#, Nianguo Dong, Peng Liu, Dan Hu, Fayuan Liu, Jiawei Shi. Perfusion decellularization method for the fabrication of decellularized porcine aortic valve scaffold. Chinese Journal of Experimental Surgery. 2016, 33(4): 1023-1025. (Chinese journal)
    20. Weihua Qiao#, Peng Liu, Jiawei Shi, Yin Wang, Nianguo Dong. Changes of Left Ventricular Morphology and Contractile Function after Mitral Valve Replacement of Patients with Mitral Stenosis and Small Left Ventricle: A Meta-analysis. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery. 2016, 23(6): 589-594. (Chinese journal)
    21. Weihua Qiao#, Nianguo Dong, Jiawei Shi. Meta-Analysis of the Association between TBX1 Gene Mutation and Conotruncal Defects. Chinese Journal of Practical Pediatrics. 2014, 29(9): 677-680. (Chinese journal)
    22. Weihua Qiao#, Nianguo Dong. Is there an age limit for the use of biologic valve? Journal of Clinical Cardiology. 2014, 30(9): 745-748. (Chinese journal)
    23. Shuyu Wen, Ying Zhou, Weihua Qiao, Yixuan Wang, Jing Zhang, Nianguo Dong. Infant heart transplantation with extremely oversized donor heart: is the donor–recipient size matching too conservative?. ESC Heart Failure. 2023, 10(2): 1431-1434.
    24. Yuanming Li, Ying Zhou, Weihua Qiao, Jiawei Shi, Xuefeng Qiu*, Nianguo Dong*. Application of decellularized vascular matrix in small-diameter vascular grafts. Frontiers in Bioengineering and Biotechnology. 2023, 10: 1081233.
    25. Yuqi Zheng, Shuyu Wen, Shijiu Jiang, Shaolin He, Weihua Qiao, Yi Liu, Wenling Yang, Jin Zhou, Boyuan Wang, Dazhu Li, Jibin Lin. CircRNA/lncRNA-miRNA-mRNA network and gene landscape in calcific aortic valve disease. BMC genomics. 2023, 24(1): 419.
    26. Yuqi Chen, Zongtao Liu, Fayuan Liu, Li Xu, Geng Li, Weihua Qiao, Yixuan Wang, Nianguo Dong. T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation. Clinical Immunology. 2023, 252: 109647.
    27. Xue Chen, Nianguo Dong, Xu Xu, Ying Zhou, Jiawei Shi, Weihua Qiao, Hao Hong. Re-endothelialization of Decellularized Scaffolds With Endothelial Progenitor Cell Capturing Aptamer: A New Strategy for Tissue-Engineered Heart Valve. ASAIO Journal. 2023, 69(9): 885-893.
    28. Shuyu Wen, Weihua Qiao, Nianguo Dong. Current status and progress of aortic valve surgery treatment. Journal of Clinical Cardiology. 2023, 39(6): 417-424. (Chinese journal)
    29. Peng Bai, Gangcheng Kong, Weihua Qiao, Yu Song, Yixuan Wang, Jiawei Shi, Nan Zhang, Chungeng Liu, Chong Chu, Tixiusi Xiong, Ying Zhou, Cuifen Lu, Lin Wang, Nianguo Dong. A Novel Method to Improve the Physical Property and Biocompatibility of Decellularized Heart Valve Scaffold with Sericin and Polydopamine. Journal of Bionic Engineering. 2022, 19(4): 1109-1123.
    30. Chanchan Song, Linli Wang, Qingyang Li, Baoyi Liao, Weihua Qiao, Qiang Li, Nianguo Dong, Liangping Li. Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells. Stem cell research & therapy. 2022, 13(1): 1-17.
    31. Ming-Hui Xie, Wei-Hua Qiao, Hong Cao, Jia-Wei Shi, Nian-Guo Dong. Progress in the Role of Mechanical Stimulus in Cardiac Development. Acta Academiae Medicinae Sinicae. 2022, 44(1): 164-172. (Chinese journal)
    32. Peng Liu, Dong-Sheng Xia, Wei-Hua Qiao, Dan Hu, Adnan Ahmed, Nian-Guo Dong, Si Chen. Which is the best prosthesis in an isolated or combined tricuspid valve replacement?. European Journal of Cardio-Thoracic Surgery. 2021, 59(1): 170-179.
    33. Shuangshuang Zhu, Yuji Xie, Weihua Qiao, Fangyan Tian, Wei Sun, Yixuan Wang, Chun Wu, He Li, Luyang Yi, Yi Zhong, Nianguo Dong, Yuman Li, Mingxing Xie, Li Zhang. Impaired left atrial function in clinically well heart transplant patients. The International Journal of Cardiovascular Imaging. 2021, 37: 1937-1945.
    34. LinXi Cheng, MingHui Xie, WeiHua Qiao, Yu Song, YanYong Zhang, YingChao Geng, WeiLin Xu, Lin Wang, Zheng Wang, Kai Huang, NianGuo Dong, YuHua Sun. Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells. Communications Biology. 2021, 4(1): 1039.
    35. Qin WANG, Yuzhi QIU, Weihua QIAO, Nianguo DONG, Yajiang YANG. Gelation Systems and Mechanisms of Chondroitin Sulfate-Based Injectable Hydrogels. Journal of Functional Polymers. 2021, 34(3): 243-259. (Chinese journal)
    36. Shuyu Wen, Weihua Qiao, Nianguo Dong. Applications of enhanced recovery after surgery in cardiovascular surgery. Journal of Clinical Cardiology. 2021, 37(9): 787-790. (Chinese journal)
    37. Ge YAN, Wei-hua QIAO, Hong CAO, Jia-wei SHI, Nian-guo DONG. Application of surface modification of polydopamine in tissue engineering. China Biotechnology. 2021, 40(12): 75-81. (Chinese journal)
    38. Shuangshuang Zhu, Wei Sun, Weihua Qiao, Meng Li, Yuman Li, Bo Liang, Jing Wang, Nianguo Dong, Li Zhang, Mingxing Xie. Real time three-dimensional echocardiographic quantification of left atrial volume in orthotopic heart transplant recipients: Comparisons with cardiac magnetic resonance imaging. Echocardiography. 2020, 37(8): 1243-1250.
    39. Peng Bai, Weihua Qiao, Nan Zhang, Chungen Liu, Jiawei Shi, Nianguo Dong. Advances in research on recellularization of tissue engineered heart valves based on decellularized matrix. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong. 2018, 47(2): 244-250. (Chinese journal)
    40. Huadong Li, Jiawei Shi, Weihua Qiao, Nianguo Dong, Gangjian Qin. Abstract 43: SIRT1 Enhances Oxidized Low-density Lipoprotein Induced Autophagy in Human Valve Interstitial Cells. Circulation Research. 2016, 119(suppl_1).
    41. Qi Liu#, Wei-Hua Qiao, Fei-fei Li, Peng Deng, and Zhi-wei Hu*. The Role of Interleukin-13 in Patients with Rheumatic Valvular Fibrosis: A Clinical and Histological Study. Journal of Heart Valve Disease. 2015, 24(4):496-501.

    More Info.
    Jian Ye
    Associate Professor
    School of Biomedical Engineering
    Shanghai Jiao Tong University
    China
    yejian78@sjtu.edu.cn
    ABSE

    Research Interest: Design, fabrication, and optical properties of nanomaterials,- Biomedical applications (biosensing, bioimaging, therapy) of nanomaterials ,- Surface-enhanced Raman scattering and related biomedical applications

    More Info.
    Yong He
    Deputy Director
    Key Lab of 3D Printing of ZheJiang Province
    ZheJiang University
    China
    yonghe@zju.edu.cn
    ABSE

    Research Interest:  Cell Printing, Now, he is especially interested in the novel cell printing method. With the different own designed cell printers, the project about how to printing vessels and the organ at the same time is underway. Organ on a chip, Now, he is especially interested in designing new method to 3D printing microfluidic chips which can be used in cell culture and the prototype of organ

    More Info.
    Petra Maresova
    petra.maresova@uhk.cz
    ABSE

    Research Interest: Business Economics, Knowledge Management, Cost Benefit Analysis Method – application in company and in medical device market development, Healthcare, efectivness of medical equipment development. 

    More Info.
    Xiaoming Li
    Assistant Professor
    School of Biological Science and Medical Engineering
    Beihang University
    China
    x.m.li@hotmail.com
    ABSE

    Research Interest:  Designing and preparing new nanobiomaterials Characterizing physical and chemical properties, biocompatibility and bioactivity of the nanobiomaterials

    More Info.
    Yanmei Tie
    Department of Neurosurgery
    Brigham and Womens Hospital
    USA
    ytie@bwh.harvard.edu
    ABSE

    Research Interest: Functional Brain Imaging, Pre-surgical Brain Mapping, Biomedical signal and Image Processing, Neural Engineering

    More Info.
    Kang Wei
    Department of Biomedical Engineering
    Ohio State University
    USA
    wei.179@osu.edu
    ABSE

    Research Interest: Biophotonics, BioMEMS, Optofluidics, Surface Wettability, Drug Delivery

    More Info.
    Tong Ming Liu
    Stem cell group
    Genome Institute of Singapore
    Singapore
    dbsliutm@yahoo.com
    ABSE

    Research Interest: Bone and cartilage disease modeling, drug screening and gene correctionDirect differentiation of pluripotent stem cells toward cartilage and boneBone reprogramming of fibroblasts using defined factors Gene therapy for cartilage regeneration and repair in regenerative medicine Signaling pathway of genes regulating cartilage differentiation of human mesenchymal stem cells.Molecular basis of mesenchymal stem cells maintaining their stemness. Stem cell biology and technique

    More Info.
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