Research Interest: Medical Image Analysis and Processing  Computer Simulations of Nanoscale Systems  Communications and Mobile Computing  Bioinformatics and Computational Biology Computational Neuroscience and Vascular Flow Dynamics Biometrics and Bio-robotics Computer Aided Diagnosis and Guided Surgerya

Research Interest: Medical Physics, Health physics, Radiation detection, Technique of Radiation Therapy, Treatment Planning in Radiation Therapy.

Research Interest: Berber phonetics, Automatic Speech processing, Speech disorders Acoustic phonetics, Automatic Speech Recognition, Speech Synthesis, Artificial Neural NetworksArabic phonetics

Weihua Qiao, MD, PhD, is a Cardiovascular Surgeon and Associate Professor of Surgery at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Dr. Qiao earned his medical degree from Chongqing Medical University in 2011. He obtained his PhD in the Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology with Dr. Nianguo Dong in 2016. His clinical interests include complex congenital cardiac surgery, minimally invasive cardiac surgery, and cardiac transplantation. Dr. Qiao serves as Principal Investigator on grants funded by National Key Research and Development Plan of China, National Natural Science Foundation of China, and other national/funding resources. His research is focused on biomedical materials and cardiovascular tissue engineering. Dr. Qiao has published more than 40 peer-review research papers including Circulation, European Heart Journal, Advanced Functional Materials and Acta Biomaterialia, and filed more than 10 patents. He has served as an editorial member and peer reviewer for several scientific journals in cardiovascular research and biomaterials. He has also served as mentor or advisor for a number of postdoctoral fellows, medical students, graduate and undergraduate students.

Research Interest: Biomedical materials and cardiovascular tissue engineering.

Publication List:

1. Ziwen Cai^#, Miaomiao Zhu^#, Li Xu^#, Yue Wang, Yin Xu, Wai Yen Yim, Hong Cao, Ruikang Guo, Xiang Qiu, Ximiao He, Jiawei Shi, Weihua Qiao* and Nianguo Dong*. Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells. Circulation. 2024. DOI: 10.1161/CIRCULATIONAHA.123.065143. (Co-corresponding author).
2. Shijie Wang, Weihua Qiao*, Nianguo Dong*. Residual shunt and microthrombosis associated with new-onset migraine after transcatheter atrial septal defect closure. European Heart Journal. 2023, 44(43): 4605-4605. (Co-corresponding author).
3. Ying Zhou^#, Ge Yan^#, Shuyu Wen, Wai Yen Yim, Zihao Wang, Xing Chen, Yin Xu, Xue Chen, Hong Cao, Peng Bai, Fei Li, Jiawei Shi, Jianglin Wang, Weihua Qiao*, Nianguo Dong*. Nitric Oxide Generation and Endothelial Progenitor Cells Recruitment for Improving Hemocompatibility and Accelerating Endothelialization of Tissue Engineering Heart Valve. Advanced Functional Materials. 2023, 33(9): 2211267. (Co-corresponding author).
4. Hong Cao^#, Qian Zhou^#, Chungeng Liu, Yecen Zhang, Minghui Xie, Weihua Qiao*, Nianguo Dong*. Substrate stiffness regulates differentiation of induced pluripotent stem cells into heart valve endothelial cells. Acta Biomaterialia. 2022, 143: 115-126. (Co-corresponding author).
5. Xing Chen, Yunlong Wu, Rui Li, Chenghao Li, Li Xu*, Weihua Qiao*, Nianguo Dong*. Galactose-modified nanoparticles for delivery of microRNA to mitigate the progress of abdominal aortic aneurysms via regulating macrophage polarization. Nanomedicine: Nanotechnology, Biology and Medicine. 2022, 44: 102564. (Co-corresponding author).
6. Shuangshuang Zhu^#, Yanting Zhang^#, Weihua Qiao^#, Yixuan Wang, Yuji Xie, Xin Zhang, Chun Wu, Guohua Wan4, Yuman Li, Nianguo Dong*, Mingxing Xie*, Li Zhang*. Incremental value of preoperative right ventricular function in predicting moderate to severe acute kidney injury after heart transplantation. Frontiers in cardiovascular medicine. 2022, 9: 931517. (Co-first author).
7. Xing Chen^#, Wei-hua Qiao^#, Hong Cao^#, Jia-wei Shi, Xin-ling Du*, Nian-guo Dong*. Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage. Current Medical Science. 2022, 42(3): 555-560. (Co-first author).
8. Shuyu Wen^#, Ying Zhou^#, Wai Yen Yim, Shijie Wang, Li Xu, Jiawei Shi, Weihua Qiao*, Nianguo Dong*. Mechanisms and Drug Therapies of Bioprosthetic Heart Valve Calcification. Frontiers in Pharmacology. 2022, 13: 909801. (Co-corresponding author).
9. Ge Yan, Yuqi Liu, Minghui Xie, Jiawei Shi, Weihua Qiao*, Nianguo Dong*. Experimental and computational models for tissue-engineered heart valves: a narrative review. Biomaterials Translational. 2021; 2(4): 361–375. (Co-corresponding author).
10. Baocheng Zhang^#, Yuan Xu^#, Sitian Ma, Linfeng Wang, Changjun Liu, Weilin Xu, Jiawei Shi, Weihua Qiao*, Hongjun Yang*. Small-diameter polyurethane vascular graft with high strength and excellent compliance            . Journal of the Mechanical Behavior of Biomedical Materials. 2021, 121: 104614. (Co-corresponding author).
11. Changjun Liu^#, Weihua Qiao^#, Chaorong Wang, Han Wang, Yingshan Zhou, Shaojin Gua, Weilin Xu, Yan Zhuang, Jiawei Shi*, Hongjun Yang*. Effect of poly (lactic acid) porous membrane prepared via phase inversion induced by water droplets on 3T3 cell behavior. International Journal of Biological Macromolecules. 2021, 183: 2205-2214. (Co-first author).
12. Chungeng Liu^#, Weihua Qiao^#, Hong Cao, Jinchi Dai, Fei Li, Jiawei Shi* and Nianguo Dong*. A riboflavin–ultraviolet light A-crosslinked decellularized heart valve for improved biomechanical properties, stability, and biocompatibility. Biomaterials Science. 2020, 8(9): 2549-2563. (Co-first author).
13. Han Wang^#, Weihua Qiao^#, Sitian Ma, Linfeng Wang, Changjun Liu, Yingshan Zhou, Shaojin Gu, Weilin Xu, Jiawei Shi*, Hongjun Yang*. Effect of temperature on the thermal property and crystallization behavior of poly (lactic acid) porous membrane prepared via phase separation induced by water microdroplets. International Journal of Biological Macromolecules. 2020, 147: 1185-1192. (Co-first author).
14. Shuyu Wen^#, Weihua Qiao^#, Yuan Zhang, and Nianguo Dong*. Development and trend in the field of valvular heart disease in China: an analysis based on the National Natural Science Foundation of China. Annals of Translational Medicine, 2020, 8(7): 449. (Co-first author).
15. Jinchi Dai^#, Weihua Qiao^#, Jiawei Shi, Chungen Liu, Xingjian Hu, Nianguo Dong. Modifying Decellularized Aortic Valve Scaffolds with Stromal Cell-derived Factor-1α Loaded Proteolytically Degradable Hydrogel for Recellularization and Remodeling. Acta Biomaterialia, 2019, 88: 280-292. (Co-first author).
16. Wei-hua Qiao^#, Peng Liu, Dan Hu, Mahmoud Al Shirbini, Xian-ming Zhou, Nian-guo Dong*. Sequential hydrophile and lipophile solubilization as an efficient method for decellularization of porcine aortic valve: structure, mechanical property and biocompatibility study. Journal of Tissue Engineering and Regenerative Medicine. 2018, 12(2): e828-e840.
17. Geng Li^#, Weihua Qiao^#, Wenjing Zhang, Fei Li, Jiawei Shi, Nianguo Dong*. The shift of macrophages toward M1 phenotype promotes aortic valvular calcification. Journal of Thoracic and Cardiovascular Surgery. 2017, 153(6): 1318-1327. e1. (Co-first author).
18. Peng Liu^#, Wei-Hua Qiao^#, Fu-Qiang Sun, Xin-Long Ruan, Mahmoud Al Shirbini, Dan Hu, Si Chen, Nian-Guo Dong*. Should a Mechanical or Biological Prosthesis Be Used for a Tricuspid Valve Replacement? A Meta-Analysis. Journal of Cardiac Surgery. 2016, 31(5): 294-302. (Co-first author).
19. Weihua Qiao^#, Nianguo Dong, Peng Liu, Dan Hu, Fayuan Liu, Jiawei Shi. Perfusion decellularization method for the fabrication of decellularized porcine aortic valve scaffold. Chinese Journal of Experimental Surgery. 2016, 33(4): 1023-1025. (Chinese journal)
20. Weihua Qiao^#, Peng Liu, Jiawei Shi, Yin Wang, Nianguo Dong. Changes of Left Ventricular Morphology and Contractile Function after Mitral Valve Replacement of Patients with Mitral Stenosis and Small Left Ventricle: A Meta-analysis. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery. 2016, 23(6): 589-594. (Chinese journal)
21. Weihua Qiao^#, Nianguo Dong, Jiawei Shi. Meta-Analysis of the Association between TBX1 Gene Mutation and Conotruncal Defects. Chinese Journal of Practical Pediatrics. 2014, 29(9): 677-680. (Chinese journal)
22. Weihua Qiao^#, Nianguo Dong. Is there an age limit for the use of biologic valve? Journal of Clinical Cardiology. 2014, 30(9): 745-748. (Chinese journal)
23. Shuyu Wen, Ying Zhou, Weihua Qiao, Yixuan Wang, Jing Zhang, Nianguo Dong. Infant heart transplantation with extremely oversized donor heart: is the donor–recipient size matching too conservative?. ESC Heart Failure. 2023, 10(2): 1431-1434.
24. Yuanming Li, Ying Zhou, Weihua Qiao, Jiawei Shi, Xuefeng Qiu*, Nianguo Dong*. Application of decellularized vascular matrix in small-diameter vascular grafts. Frontiers in Bioengineering and Biotechnology. 2023, 10: 1081233.
25. Yuqi Zheng, Shuyu Wen, Shijiu Jiang, Shaolin He, Weihua Qiao, Yi Liu, Wenling Yang, Jin Zhou, Boyuan Wang, Dazhu Li, Jibin Lin. CircRNA/lncRNA-miRNA-mRNA network and gene landscape in calcific aortic valve disease. BMC genomics. 2023, 24(1): 419.
26. Yuqi Chen, Zongtao Liu, Fayuan Liu, Li Xu, Geng Li, Weihua Qiao, Yixuan Wang, Nianguo Dong. T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation. Clinical Immunology. 2023, 252: 109647.
27. Xue Chen, Nianguo Dong, Xu Xu, Ying Zhou, Jiawei Shi, Weihua Qiao, Hao Hong. Re-endothelialization of Decellularized Scaffolds With Endothelial Progenitor Cell Capturing Aptamer: A New Strategy for Tissue-Engineered Heart Valve. ASAIO Journal. 2023, 69(9): 885-893.
28. Shuyu Wen, Weihua Qiao, Nianguo Dong. Current status and progress of aortic valve surgery treatment. Journal of Clinical Cardiology. 2023, 39(6): 417-424. (Chinese journal)
29. Peng Bai, Gangcheng Kong, Weihua Qiao, Yu Song, Yixuan Wang, Jiawei Shi, Nan Zhang, Chungeng Liu, Chong Chu, Tixiusi Xiong, Ying Zhou, Cuifen Lu, Lin Wang, Nianguo Dong. A Novel Method to Improve the Physical Property and Biocompatibility of Decellularized Heart Valve Scaffold with Sericin and Polydopamine. Journal of Bionic Engineering. 2022, 19(4): 1109-1123.
30. Chanchan Song, Linli Wang, Qingyang Li, Baoyi Liao, Weihua Qiao, Qiang Li, Nianguo Dong, Liangping Li. Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells. Stem cell research & therapy. 2022, 13(1): 1-17.
31. Ming-Hui Xie, Wei-Hua Qiao, Hong Cao, Jia-Wei Shi, Nian-Guo Dong. Progress in the Role of Mechanical Stimulus in Cardiac Development. Acta Academiae Medicinae Sinicae. 2022, 44(1): 164-172. (Chinese journal)
32. Peng Liu, Dong-Sheng Xia, Wei-Hua Qiao, Dan Hu, Adnan Ahmed, Nian-Guo Dong, Si Chen. Which is the best prosthesis in an isolated or combined tricuspid valve replacement?. European Journal of Cardio-Thoracic Surgery. 2021, 59(1): 170-179.
33. Shuangshuang Zhu, Yuji Xie, Weihua Qiao, Fangyan Tian, Wei Sun, Yixuan Wang, Chun Wu, He Li, Luyang Yi, Yi Zhong, Nianguo Dong, Yuman Li, Mingxing Xie, Li Zhang. Impaired left atrial function in clinically well heart transplant patients. The International Journal of Cardiovascular Imaging. 2021, 37: 1937-1945.
34. LinXi Cheng, MingHui Xie, WeiHua Qiao, Yu Song, YanYong Zhang, YingChao Geng, WeiLin Xu, Lin Wang, Zheng Wang, Kai Huang, NianGuo Dong, YuHua Sun. Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells. Communications Biology. 2021, 4(1): 1039.
35. Qin WANG, Yuzhi QIU, Weihua QIAO, Nianguo DONG, Yajiang YANG. Gelation Systems and Mechanisms of Chondroitin Sulfate-Based Injectable Hydrogels. Journal of Functional Polymers. 2021, 34(3): 243-259. (Chinese journal)
36. Shuyu Wen, Weihua Qiao, Nianguo Dong. Applications of enhanced recovery after surgery in cardiovascular surgery. Journal of Clinical Cardiology. 2021, 37(9): 787-790. (Chinese journal)
37. Ge YAN, Wei-hua QIAO, Hong CAO, Jia-wei SHI, Nian-guo DONG. Application of surface modification of polydopamine in tissue engineering. China Biotechnology. 2021, 40(12): 75-81. (Chinese journal)
38. Shuangshuang Zhu, Wei Sun, Weihua Qiao, Meng Li, Yuman Li, Bo Liang, Jing Wang, Nianguo Dong, Li Zhang, Mingxing Xie. Real time three-dimensional echocardiographic quantification of left atrial volume in orthotopic heart transplant recipients: Comparisons with cardiac magnetic resonance imaging. Echocardiography. 2020, 37(8): 1243-1250.
39. Peng Bai, Weihua Qiao, Nan Zhang, Chungen Liu, Jiawei Shi, Nianguo Dong. Advances in research on recellularization of tissue engineered heart valves based on decellularized matrix. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong. 2018, 47(2): 244-250. (Chinese journal)
40. Huadong Li, Jiawei Shi, Weihua Qiao, Nianguo Dong, Gangjian Qin. Abstract 43: SIRT1 Enhances Oxidized Low-density Lipoprotein Induced Autophagy in Human Valve Interstitial Cells. Circulation Research. 2016, 119(suppl_1).
41. Qi Liu^#, Wei-Hua Qiao, Fei-fei Li, Peng Deng, and Zhi-wei Hu*. The Role of Interleukin-13 in Patients with Rheumatic Valvular Fibrosis: A Clinical and Histological Study. Journal of Heart Valve Disease. 2015, 24(4):496-501.

Research Interest: Applied research specifically in tissue engineering, biomaterials and regenerative medicine. Currently focus is bionanomedicine, bionanocomposites and bionanotechnology

Research Interest: Electroporation, Electroloading, Electrochemotherapy, Drug and Gene Delivery Systems, Molecular Imaging (EPR imaging; optical imaging; multimodal imaging – MRI/EPR, MRI/optical), Cancer Biochemistry

Research Interest: Design, fabrication, and optical properties of nanomaterials,- Biomedical applications (biosensing, bioimaging, therapy) of nanomaterials ,- Surface-enhanced Raman scattering and related biomedical applications

Research Interest: His research focuses on computer assisted surgery, including medical image analysis, surgical navigation, surgery simulation, surgical robots, biomedical manufacturing, etc.

Research Interest:  Designing and preparing new nanobiomaterials Characterizing physical and chemical properties, biocompatibility and bioactivity of the nanobiomaterials

Research Interest:  Cell Printing, Now, he is especially interested in the novel cell printing method. With the different own designed cell printers, the project about how to printing vessels and the organ at the same time is underway. Organ on a chip, Now, he is especially interested in designing new method to 3D printing microfluidic chips which can be used in cell culture and the prototype of organ

Research Interest:  His research interests concentrate on the biosensors (e.g. living cell sensor, DNA sensor and protein sensor) and BioMEMS system.

Research Interest:  His research interests concentrate on the biosensors (e.g. living cell sensor, DNA sensor and protein sensor) and BioMEMS system.

Research Interest:  Biofabrication, Selective laser sintering, Nanotechnology, 3D Printing Biomaterials, Tissue Engineering

Research Interest:  Biomedical  instrumentation,  Health  monitoring  system,  System  modeling  and control, robotics

Research Interest:  Non-point source, soil heavy metal, absorbing Material, and restoration

Dr. Rajasekharredy Pala is a Nano biotechnologist specialized in the synthesis of various metal and metal oxide nanoparticles with their application as drug delivery agents to the primary cilia. After his post-graduation he was selected for ICMR-Senior Research Fellowship under Biomedical Sciences in 2011 and during this period of his doctoral studies at CSIR-Indian Institute of Chemical Technology, India, he has earned handsome experience on the physical and chemical characterizations techniques of nanoparticles that are enveloped with various biologically active compounds such as protein, lipids and small molecular drugs for their biomedical applications. Dr. Pala working as a research associate in Chapman University and University of California Irvine from 2015.

Research Interest: Nanomedicine, Hypertension, Cancer, Renal diseases

URL: https://sites.chapman.edu/cilia/pala-rajasekharreddy/

Skype ID: raaja.biotech

List of Publications: 

Rajasekharreddy Pala, Ashraf M. Mohieldin, Kiumars Shamloo, Rinzhin T. Sherpa, Sarmed H.

Kathem, Jing Zhou, Zhongyue Luan, Jian-Guo Zheng, Amir Ahsan, and Surya M. Nauli.

Personalized Nanotherapy by Specifically Targeting Cell Organelles To Improve Vascular

Hypertension. Nano Letters Article ASAP DOI: 10.1021/acs.nanolett.8b04138

2. Zeng, Y., Zhu, J., Wang, J., Parasuraman, P., Busi, S., Nauli, S. M., Wáng, Y., Pala,

Rajasekharreddy, Liu, G. (2018). Functional probes for cardiovascular molecular

imaging. Quantitative imaging in medicine and surgery, 8(8), 838-852 (co-corresponding

author).

3. Pala, Rajasekharreddy., Jamal, M., Alshammari, Q., Nauli, S.M. The Roles of Primary Cilia in

Cardiovascular Diseases. Cells 2018, 7, 233. (Published as cover page)

4. Rajasekharreddy Pala, Yun Zeng, Subhaswaraj Pattnaik, Siddhardha Busi, Alomari Nedaa,

Nauli Surya M, Gang Liu, (2018). Functionalized Silver Nanoparticles for Sensing, Molecular

Imaging and Therapeutic Applications. Current Nanomedicine, Pages 1 - 17 (17).

5. Pala Rajasekharreddy, Pathipati Usha Rani, Mattapally Saidulu & Sanjay K. Banerjee (2017).

Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus

aureus disease in silkworm model, Materials Science and Engineering: C, 77, 990-1002

(corresponding author).

6. Pala Rajasekharreddy, Chao Huang, Siddhardha Busi, Jobina Rajkumari, Ming-Hong Tai, Gang

Liu (2017). Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment:

Principles, Challenges and the Road Ahead. Current Medicinal Chemistry, 24, 1-17. Doi.

10.2174/0929867324666170309124327.

7. Jobina Rajkumari, Siddhardha Busi, Aneesh Cherukunnel Vasu, Pala Rajasekharreddy (2017),

Facile green synthesis of baicalein fabricated gold nanoparticles and their antibiofilm activity

against Pseudomonas aeruginosa PAO1. Microbial Pathogenesis, 107: 261-269.

8. Rajasekharreddy Pala, Nedaa Alomari, Surya M. Nauli (2017). Primary Cilium-Dependent

Signaling Mechanisms, International Journal of Molecular Sciences, 18, 2272.

9. Kiumars Shamloo, Juan Chen, Jasmine Sardar, Rinzhin T. Sherpa, Rajasekharreddy

Pala, Kimberly F. Atkinson,William J. Pearce, Lubo Zhang, Surya M. Nauli (2017). Chronic

Hypobaric Hypoxia Modulates Primary Cilia Differently in Adult and Fetal Ovine Kidneys.

Frontiers in Physiology, 8: 677.

10. Nauli, Surya M., Rajasekharreddy Pala, and Steven J. Kleene (2016). "Calcium channels in

primary cilia." Current Opinion in Nephrology and Hypertension 25 (5): 452-458.

11. Pala Rajasekharreddy and Pathipati Usha Rani (2014). Biofabrication of Ag nanoparticles using

Sterculia foetida L. seed extract and their toxic potential against mosquito vectors and HeLa

cancer cells. Materials Science and Engineering: C, 39, 203-212.

12. Pala Rajasekharreddy and Pathipati Usha Rani (2014). Biosynthesis and characterization of Pd

and Pt nanoparticles using Piper betle L. plant in a photoreduction method. Journal of Cluster

Science, 25: 1377-1388.

13. Praveen Kumar Kalavagunta, Rajasekharreddy Pala, Usha Rani Pathipati and Narender Ravirala

(2014). Identification of β-Naphthol derivatives as novel antifeedants and insecticides-I. Journal

of Agricultural and Food Chemistry, 62, 6571−6576.

14. Pala Rajasekharreddy and Pathipati Usha Rani (2012) Nontoxic effects of biologically

synthesized silver nanoparticles on silkworm, Bombyx mori L. Hexapoda 19 (1): 74–78.

Pathipati Usha Rani and Pala Rajasekharreddy (2011) Green synthesis of silver-protein (core–

shell) nanoparticles using Piper betle L. leaf extract and its ecotoxicological studies on Daphnia

magna. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 389 (1-3): 188-194.

16. Pathipati Usha Rani, Pala Rajasekharreddy and Kommu Nagaiah (2011). Allelopathic effects of

(2n-octylcycloprop-1-enyl)-octanoic acid (I) against Four Major Weeds. Allelopathy Journal. 28

(2) 179-188.

17. Pala Rajasekharreddy, Pathipati Usha Rani and Bojja Sreedhar (2010). Qualitative assessment of

silver and gold nanoparticle synthesis in various plants: a photobiological approach. Journal of

Nanoparticle Research, 12: 1711-1721.

18. Pala Rajasekharreddy and Pathipati Usha Rani (2010). Toxic properties of certain botanical

extracts against three major stored product pests. Journal of Biopesticides. 3(3): 586-589.

19. Pathipati Usha Rani and Pala Rajasekharreddy (2010). Insecticidal activity of (2n-octylcycloprop-

1-enyl)-octanoic acid (I) against three coleopteran stored product insects from Sterculia foetida

(L.). Journal of Pest Science, 83(3); 273-279.

20. Pathipati Usha Rani and Pala Rajasekharreddy (2009). Toxic and antifeedant activities of Sterculia

foetida (L.) seed crude extract against Spodoptera litura (F.) and Achaea janata (L.). Journal of

Biopesticides 2(2): 161-164.

Pathipati Usha Rani and Pala Rajasekharreddy (2013). Plants: The green factories for synthesis

of nanomaterials” in the book “Nanotechnology Environment” Edited by J.N. Govil. Studium Press

LLC, USA.

A method for isolation of an Ortho Quinone Methide intermediate. Pala Rajasekharreddy

and K.P Kumar and (PCT/IB2015/057628), WIPO publication no. WO/2016/059511.

• Green synthesis of highly monodispersed silver nanoparticles by plant. P. Usha Rani and Pala

Rajasekharreddy (File No. 4020/DEL/2012).

• Novel synthesis of 2-aminobenzothiazolomethyl naphthol derivatives and their

antifeedant activity. KP Kumar, Pala Rajasekharreddy, V. Narendar & P. Usha Rani (File No

0802/DEL/2013).

Research Interest: Super-resolution technology; Stochastic Optical Reconstruction Microscopy(STORM); Cell Imaging and Structure; Propagation and Scattering of Light in Random and Complex Media; Classical Coherence Theory; Laser Communications and LaserRadar Systems; Near-field Scattering; Optical Imaging System

Research Interest: Image / signal processing, Machine learning, Computer-aided clinical diagnosis and treatment selection

Research Interest: Biophotonics, BioMEMS, Optofluidics, Surface Wettability, Drug Delivery

Research Interest: Functional Brain Imaging, Pre-surgical Brain Mapping, Biomedical signal and Image Processing, Neural Engineering

Biography:

My research focuses on establishing the clinical applicability of two new diagnostic parameters (to detect coronary artery disease) using a set of bench-top experiments, computational analysis, pre-clinical and clinical trials in our research group. These proposed diagnostic parameters based on fluid dynamic principles, pressure drop coefficient and lesion flow coefficient, have the potential to make a real paradigm shift in clinical decision making related to cardiovascular intervention. As part of my research involving pre-clinical and clinical trials I had collaborated with clinicians and scientists at College of Medicine, University of Cincinnati and at Cincinnati Children's Hospital and Medical Center. Preliminary results from these studies have concluded the clinical applicability of these parameters to distinguish between stenoses of various severity.
More recently, at Weill Cornell Medical College, I am working on using 3D printing, machine learning and computational fluid dynamics to predict and prevent coronary artery disease from non-invasive CCTA imaging data.

Research Interest: 3D printing, Computational fluid dynamics, clinical radiology, non-invasive CCTA scanning, machine learning, interventional cardiology, applied mathematics, bio-heat transfer

List of Publications:

1. Al'Aref SJ, Anchouche K, Singh G, Slomka PJ, Kolli KK, Kumar A, Pandey M, Maliakal G, van Rosendael AR, Beecy AN, Berman DS, Leipsic J, Nieman K, Andreini D, Pontone G, Schoepf UJ, Shaw LJ, Chang HJ, Narula J, Bax JJ, Guan Y, Min JK. Clinical applications of machine learning in cardiovascular disease and its relevance to cardiac imaging. Eur Heart J. 2018. Epub 2018/07/31. doi: 10.1093/eurheartj/ehy404. PubMed PMID: 30060039. Available from: https://www.ncbi.nlm.nih.gov/pubmed/30060039.

2. Kolli KK, Min JK. Image-based computational fluid dynamic analysis for surgical planning of sequential grafts in coronary artery bypass grafting. Accepted as Contributed full paper for publication in Conference Proceedings for IEEE Engineering in Medicine and Biology Society Conference. 2018. [Accepted]

3. van Rosendael AR, Maliakal G, Kolli KK, Beecy A, Al'Aref SJ, Dwivedi A, Singh G, Panday M, Kumar A, Ma X, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Gransar H, Lu Y, Jones EC, Pena JM, Lin FY, Min JK. Maximization of the usage of coronary CTA derived plaque information using a machine learning based algorithm to improve risk stratification; insights from the CONFIRM registry. J Cardiovasc Comput Tomogr. 2018;12(3):204-9. Epub 2018/05/14. doi: 10.1016/j.jcct.2018.04.011. PubMed PMID: 29753765. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29753765.

4. Singh G, Al'Aref SJ, Van Assen M, Kim TS, van Rosendael A, Kolli KK, Dwivedi A, Maliakal G, Pandey M, Wang J, Do V, Gummalla M, De Cecco CN, Min JK. Machine learning in cardiac CT: Basic concepts and contemporary data. J Cardiovasc Comput Tomogr. 2018; 12(3):192-201. Epub 2018/05/15. doi: 10.1016/j.jcct.2018.04.010. PubMed PMID: 29754806. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29754806.

5. Beecy AN, Chang Q, Anchouche K, Baskaran L, Elmore K, Kolli KK, Wang H, Al'Aref S, Pena JM, Knight-Greenfield A, Patel P, Sun P, Zhang T, Kamel H, Gupta A, Min JK. A Novel Deep Learning Approach for Automated Diagnosis of Acute Ischemic Infarction on Computed Tomography. JACC Cardiovascular imaging. 2018. Epub 2018/05/21. doi: 10.1016/j.jcmg.2018.03.012. PubMed PMID: 29778866. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29778866.

6. Peelukhana SV, Banerjee R, van de Hoef TP, Kolli KK, Effat M, Helmy T, Leesar M, Kerr H, Piek JJ, Succop P, Back L, Arif I. Evaluation of lesion flow coefficient for the detection of coronary artery disease in patient groups from two academic medical centers. Cardiovascular Revascularization
Kranthi Kolli 6 10/05/2018Medicine. 2018;19(3 Pt B):348-54. Epub 2017/10/19. doi: 10.1016/j.carrev.2017.08.018. PubMed PMID: 29037762. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29037762.

7. Han D, Starikov A, Xiong G, Hartaigh B, Granser H, Kolli KK, Lee J, Rizvi A, Baskaran L, Schulman-Marcus J, Lin FY, Min JK. Relationship between endothelial wall shear stress and high-risk atherosclerotic plaque characteristic for identification of coronary lesions that cause ischemia: A direct comparison to fractional flow reserve. Journal of the American Heart Association. 2016; 5(12). doi: 10.1161/JAHA.116.004186. PubmMed PMID: 27993831. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27993831

8. Kolli KK, Min JK, Ha S, Soohoo H, Xiong G. Effect of Varying Hemodynamic and Vascular Conditions on Fractional Flow Reserve: An In Vitro Study. Journal of the American Heart Association. 2016;5(7). doi: 10.1161/JAHA.116.003634. PubMed PMID: 27364988. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27364988.

9. Kolli KK, van de Hoef TP, Effat MA, Banerjee RK, Peelukhana SV, Succop P, Leesar MA, Imran A, Piek JJ, Helmy TA. Diagnostic cutoff for pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve: A patient-level analysis. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2016;87(2):273-82. doi: 10.1002/ccd.26063. PubMed PMID: 26424295. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26424295.

10. Peelukhana SV, Effat M, Kolli KK, Arif I, Helmy T, Leesar M, Kerr H, Back LH, Banerjee R. Lesion flow coefficient: a combined anatomical and functional parameter for detection of coronary artery disease--a clinical study. The Journal of invasive cardiology. 2015;27(1):54-64. PubMed PMID: 25589702. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25589702.

11. Peelukhana SV, Banerjee R, Kolli KK, Fernandez-Ulloa M, Arif I, Effat M, Helmy T, Kerr H. Benefit of ECG-gated rest and stress N-13 cardiac PET imaging for quantification of LVEF in ischemic patients. Nuclear medicine communications. 2015;36(10):986-98. doi: 10.1097/MNM.0000000000000352. PubMed PMID: 26225941. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26225941.

12. Peelukhana SV, Kolli KK, Leesar MA, Effat MA, Helmy TA, Arif I, Schneeberger EW, Succop P, Banerjee RK. Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model. Heart and vessels. 2014;29(1):97-109. doi: 10.1007/s00380-013-0355-9. PubMed PMID: 23624760. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23624760.

13. Peelukhana SV, Kerr H, Kolli KK, Fernandez-Ulloa M, Gerson M, Effat M, Arif I, Helmy T, Banerjee R. Benefit of cardiac N-13 PET CFR for combined anatomical and functional diagnosis of ischemic coronary artery disease: a pilot study. Annals of nuclear medicine. 2014;28(8):746-60. doi: 10.1007/s12149-014-0869-y. PubMed PMID: 24950752. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24950752.

14. Kolli KK, Helmy TA, Peelukhana SV, Arif I, Leesar MA, Back LH, Banerjee RK, Effat MA. Functional diagnosis of coronary stenoses using pressure drop coefficient: a pilot study in humans. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2014;83(3):377-85. doi: 10.1002/ccd.25085. PubMed PMID: 23785016. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23785016.

15. Kolli KK, Effat MA, Peelukhana SV, Succop P, Back LH, Leesar MA, Helmy TA, Imran A, Banerjee RK. Hyperemia-free delineation of epicardial and microvascular impairments using a basal index. Annals of biomedical engineering. 2014;42(8):1681-90. doi: 10.1007/s10439-014-1020-x. PubMed PMID: 24806315. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24806315.
Kranthi Kolli 7 10/05/2018

16. Kolli KK, Arif I, Peelukhana SV, Succop P, Back LH, Helmy TA, Leesar MA, Effat MA, Banerjee RK. Diagnostic performance of pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve. The Journal of invasive cardiology. 2014;26(5):188-95. PubMed PMID: 24791716. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24791716.

17. Kolli KK, Paul AK, Back LH, Effat MA, Banerjee RK. Optimization of balloon obstruction for simulating equivalent pressure drop in physiological stenoses. Biorheology. 2013;50(5-6):257-68. doi: 10.3233/BIR-130640. PubMed PMID: 24398608. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24398608.

18. Peelukhana SV, Banerjee RK, Kolli KK, Effat MA, Helmy TA, Leesar MA, Schneeberger EW, Succop P, Gottliebson W, Irif A. Effect of heart rate on hemodynamic endpoints under concomitant microvascular disease in a porcine model. American journal of physiology Heart and circulatory physiology. 2012;302(8):H1563-73. doi: 10.1152/ajpheart.01042.2011. PubMed PMID: 22287585. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22287585.

19. Kolli KK, Banerjee RK, Peelukhana SV, Effat MA, Leesar MA, Arif I, Schneeberger EW, Succop P, Gottliebson WM, Helmy TA. Effect of changes in contractility on pressure drop coefficient and fractional flow reserve in a porcine model. The Journal of invasive cardiology. 2012;24(1):6-12. PubMed PMID: 22210582. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22210582.

20. Rajabi-Jaghargh E, Kolli KK, Back LH, Banerjee RK. Effect of guidewire on contribution of loss due to momentum change and viscous loss to the translesional pressure drop across coronary artery stenosis: an analytical approach. Biomedical engineering online. 2011;10:51. doi: 10.1186/1475-925X-10-51. PubMed PMID: 21658283; PMCID: 3141581. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21658283.

21. Kolli KK, Banerjee RK, Peelukhana SV, Helmy TA, Leesar MA, Arif I, Schneeberger EW, Hand D, Succop P, Gottliebson WM, Effat MA. Influence of heart rate on fractional flow reserve, pressure drop coefficient, and lesion flow coefficient for epicardial coronary stenosis in a porcine model. American journal of physiology Heart and circulatory physiology. 2011;300(1):H382-7. doi: 10.1152/ajpheart.00412.2010. PubMed PMID: 20935151. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20935151.

Research Interest: Time-domain optical brain imaging, functional near-infrared  ectroscopy,  fluorescence measurements, analyses of an optical properties of the media, development of optical imaging systems, brain optics, clinical applications

Research Interest: Tissue & organ repair and regeneration, Tissue engineering, Wound healing, Clinical medicine, dimensional tissue equivalent models, Novel wound and scar remediation therapies, Chinese herbal medicine, Growth factor/extracellular matrix protein complexes, Pharmaceutical and drugs

Research Interest: Surgical planning and simulation in esthetical facial surgeryTelemedicine o Biomedical engineering 

Research Interest: Development of new lanthanide complexes for MRI and optical imaging: synthesis, purification (HPLC, flash chromatography) and physicochemical characterization (NMR spectroscopy, mass spectrometry, luminescence, UV-visible, FTIR).  

Dr. Mohammed Rachidi received his PhD/ Doctorate Degree in Human and Molecular Genetics (with High Honors) at the prestigious ''Pasteur Institute'' (Paris, France), in the Department of Molecular and Cellular Genetics headed by the Professor François JACOB (Nobel Prize in Physiology/Medicine), where he studied the Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System development, CaMKinases & Biological Clock Function in Drosophila. Dr. Rachidi extended these Molecular Genetics works to Functional Genomics at Pasteur Institute and at Center National of Research Scientific CNRS and played key fundamental roles in different collaborative research projects with prestigious laboratories in Europe, Japan & United States. Remarkably, Dr. Rachidi collaborated with the Professor Michael ROSBASH (Nobel Prize in Physiology/Medicine 2017) in the Molecular Mechanisms of 2 genes involved in Circadian Clock.  Dr. Rachidi published with Professor ROSBASH this important work in the EMBO Journal Entitled : ''A New Gene encoding a putative Transcritpion Factor Regulated by the Drosophila Circadian Clock''. Postdoctoral training & Assistant Professor with Professor Nicole LeDOUARIN at the prestigious ''College De France'' & Institute of Cellular & Molecular Embryology (Paris), Dr. Rachidi studied some Chicken & Xenopus molecules acting in Bone Morphogenetic Protein BMP signaling pathways and identified their Mouse & Human homologs involved in differentiation of specific domains of neuronal progenitors, in cerebellum development and Joubert syndrome (a form of cerebellar ataxia). These experiences of Dr. Rachidi in the Molecular Genetics and in several Animal Models were extended to Human Molecular Genetics of Down syndrome (DS) & to Molecular and Cellular Mechanisms underlying Brain morphogenesis of Trisomic & Transgenic Mouse Models of DS and also of numerous stages of Embryonic & Fetal DS patients to elucidate the Neurogenetic Basis of Functional alterations Associated with Mental Retardation. Director of Research in Human Molecular Genetics, Faculty of Medicine University Paris 5 (France), with High Honours for Notable Scientific Research Contributions, Breakthroughs & Discoveries in Drosophila & Mouse & Human Molecular Genetics & Neurosciences, Dr. Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neuroscience & Biomedical Research. Dr. Rachidi realized numerous ''Discoveries and Innovations'' to name a few:  (1) - Discovery of Quantitative Assessment of Gene [removed]QAGE) as a New Method in situ detecting Differential Overexpression of Candidate Genes for Mental Retardation in Down syndrome Brain Regions & for Other Diseases caused by Regionalized Quantitative Transcriptional Alterations for greater interpretation of functional processes driving gene expression. (2) - Discovery of New Cerebellar & Cerebral Phenotypes in Transgenic mouse in vivo Library of Human Down syndrome Critical Region. (3) - Discovery of a Novel Light Microscopy Technology as Powerful Tool in Developmental Biology & Biomedical & Neuroscience Research. (4) - Discovery of New Genes involved in Brain Morphogenesis & in Visual System development; in Biological Clock; in Learning & Memory and in Mental Retardation in Down syndrome & Joubert syndrome. (5) - Discovery of the First Proposed Model of Molecular and Cellular Mechanism Elucidating Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Mental Retardation in Down syndrome: in this Model Gene Dosage Effects on transcriptional variations and the nature of gene products and their functional relationships are explained with the different aspects of neuronal differentiation. Dr. Rachidi published numerous articles in highly Prestigious International Journals with High Impact Factor like EMBO, Genomics, DNA Research, Gene, Mechanisms of Development, Cytogenetics & Genome Research, Neuroscience Research, International Journal of Developmental Neuroscience, Cell Tissue Research, American Journal of Intellectual Developmental Disability, European Journal of Paediatric Neurology...and in numerous journals of Elsevier & Springer. He has also authored numerous Chapters & Books. Dr. Rachidi has been honoured worldwide as Invited Distinguished Speaker, Chairman or Invited Honourable Organizing Committee Member in numerous International Conferences, Seminars & Workshops in Europe, USA & Asia. Dr Rachidi received numerous Awards & Honors and He is an Editor, Associate Editor, Executive Editor & Editor in Chief in numerous International peer-reviewed Journals.

Research Interest:

Dr. Mohammed Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neurosciences & Biomedical Research, to name a few : Cellular & Molecular Mechanisms underlying Brain Morphogenesis, Visual System, Biological Clock, Synaptic Protein Targeting, Synaptic Plasticity, CaMKII & CAMGUK/MAGUK, Learning and Memory. Functional Genomics & Mechanisms controlling Transposition at Cell Cycle. Transcription, Protein Translation & Virus-Like Particle Formation. Bone Morphogenetic Protein BMP signaling pathways, Mouse and Human Homeobox Genes, Cell Fate Determination and Differentiation, Neuronal Progenitors in Cerebellum development and Joubert syndrome. Trisomy 21, Intellectual Disability, Candidate Genes, Expression studies, Genotype-Phenotype Associations, Trisomic and Transgenic Mouse Models of Down syndrome, Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability.  Drosophila & Mouse & Human.

List of Publications:

- Rachidi, M. (2019). Pharmacotherapeutic Challenges for Rescuing Mental Retardation and Improving Brain Function in Down Syndrome.  Biophamaceutics and Therapeutic Challenges, 2019, (In Press).

- Rachidi, M. (2018). The Genetic Dosage Imbalance Linked to Clinical Brain Alterations and Mental Disability in Down syndrome could be Targeted for Therapeutics Development.
Medical Journal of Clinical Trials and Case studies. 2018, 2 (5): 000150.

- Rachidi, M. (2018). The Molecular Pathogenesis of Down Syndrome-Associated Diseases and the Promising Potential Therapeutic Targets.
Clinical and Medical Investigations, 2018, Vol. 3(1), 1-2.

- Rachidi, M. (2018). Trisomy of Chromosome 21 provides a Genetic Model for the Role of Aneuploidy in Cell Cycle Alterations, Leukemia, Tumors and Cancer   (In Press).

- Rachidi, M. (2016). Neurogenetic Disorders of Down Syndrome and Potential Pharmacotherapies for Mental Retardation.
American Journal of Clinical Neurology and Neurosurgery, 2016, Vol. 2, No. 4, 2016, pp. 45-49.

- Rachidi, M. (2015). Towards the Identification of Genetic Targets for Therapeutics of Intellectual Disability in Down syndrome.
J.J. Cenetics, 2015.

- Rachidi, M. and Lopes, C. (2013).  Mental Retardation and Human Chromosome 21 Gene Overdosage: From Functional Genomics and Molecular Mechanisms towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome.
Handbook of Neurochemistry and Molecular Neurobiology. In Genomics, Proteomics, and the Nervous System, Advances in Neurobiology, Springer Publishers 3rd Ed 2013.

- Rachidi M., Tetaria C., Lopes C. (2011). “Cell cycle alteration in Down syndrome”. In Berhardt LV. (Ed.), Advances in Medicine and Biology, 2011, Vol. 20. Nova Science Publisher.

- Rachidi, M. and Lopes, C. (2010). Molecular and Cellular Mechanisms Elucidating the Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability in Down syndrome.
American Journal of  Intellectual Developmental Disabilities, 2010; 115., 83-112.

- Rachidi, M. and Lopes, C. (2010). Cell Cycle Alteration in Down syndrome.
International Journal of Medical and Biological Frontiers, 2010, Volume 16, Issue 3/4,  Nova Science Publishers.

- Rachidi, M. and Lopes, C. (2009). Gene Expression Regulation in Down syndrome: Dosage Imbalance Effects at Transcriptome and Proteome Levels. Handbook of Down syndrome Research, Edition Nova Science Publishers, Inc., 2009, 55-87

- Rachidi, M., Delezoide, A-L., Delabar, J.M. and Lopes, C. (2009). A quantitative assessment of gene [removed]QAGE) reveals differential overexpression of DOPEY2, a candidate gene for mental retardation, in Down syndrome brain regions.
International Journal of Developmental Neuroscience, 2009, 27, 393-398.

- Rachidi, M., Tetaria, C., and Lopes, C. (2008). Trisomy of Human Chromosome 21 and Cell Cycle Control. In Leroy NH., Fournier NT. (Eds.): Cell Cycle Control: New Research, Nova Science Publishers, Inc., 2008, 159-189.

- Rachidi, M. and Lopes, C. (2008). Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways.
European Journal of Paediatric Neurology, 2008, 12, 168-182.

- Rachidi, M. and Lopes, C. (2008). Molecular Mechanisms of Mental Retardation in Down syndrome. Rachidi, M. and Lopes, C. (Editors), Nova Biomedical Book: Edition Nova Science Publishers, Inc., 2008, pp 1-94.

- Rachidi, M., Lopes, C.; C Vayssettes, D J. Smith, E M Rubin, J.M Delabar. (2007). New Cerebellar Phenotypes in YAC Transgenic mouse in vivo Library of Human Down syndrome Critical Region 1.
Biochemical Biophysical Research Communications, 2007, 364(3), 488-494.

- Rachidi, M. and Lopes, C. (2007). Molecular Mechanisms of Mental Retardation in Down Syndrome. In Carson MI. (Ed.): Focus on Mental Retardation Research. Nova Science Publishers, Inc. 2007, pp. 77-134.

- Rachidi, M. and Lopes, C. (2007). Mental retardation in Down syndrome: From gene dosage imbalance to molecular and cellular mechanisms.
Neuroscience Research, 2007, 59(4), 349-369.

- Rachidi, M. and Lopes, C. (2006). Differential transcription of Barhl1 homeobox gene in restricted functional domains of the central nervous system suggests a role in brain patterning.
International Journal of Developmental Neuroscience, 2006, 24(1), 35-44.

- Rachidi, M., Lopes, C., Delezoide, A.L. and Delabar, J.M. (2006). C21orf5, a human candidate gene for brain abnormalities and mental retardation in Down Syndrome.
Cytogenetics and Genome Research, 2006, 112(1-2), 16-22.

- Lopes, C., Delezoide, A.L., Delabar, J.M. and Rachidi, M. (2006). BARHL1 homeogene, the human ortholog of the mouse Barhl1 involved in cerebellum development, shows regional and cellular specificities in restricted domains of developing human central nervous system.
Biochemical Biophysical Research Communications, 2006, 339, 296-304.

- Rachidi, M., Lopes, C., Costantine, M. and Delabar J.M. (2005). C21orf5, a new member of dopey family involved in morphogenesis, could participate to neurological alterations and mental retardation in Down syndrome.
DNA Research, 2005, 12, 203-210.

- Rachidi, M., Lopes, C., Charron, G., Delezoide, AL., Paly, E., Bloch, B. and Delabar, JM. (2005). Spatial and temporal localization during embryonic and fetal human development of the transcription factor SIM2 in brain regions altered in Down syndrome.
International Journal of Developmental Neuroscience, 2005, 23, 475-484.

- Rachidi, M., Lopes, C., Benichou, J.C., Hellio, R. and Maisonhaute, C. (2005). Virus-like particle formation in Drosophila melanogaster germ cells suggests a complex translational regulation of the retrotransposon cycle and new mechanisms inhibiting transposition.
Cytogenetics and Genome Research, 2005, 111(1), 88-95.

- Lopes, C., Chettouh, Z., Delabar, J.M. and Rachidi, M. (2003). The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice. Biochemical Biophysical Research Communications, 2003, 305, 915-924.

- Takamatsu, Y., *Nakagoshi, H., *Rachidi, M., Lopes, C. Nishida, Y. and Ohsako, S. (2002). Characterization of the dCaMKII-GAL4 driver line whose expression is controlled by the. Drosophila Ca²+/calmodulin dependent protein kinase II promoter.
Cell Tissue Research., 2002, 310(2), 237-252.

- Lopes, C., Gassanova, S., Delabar, J.M. and Rachidi, M. (2001). The CASK/Lin-2 Drosophila Homologue, Camguk, Could Play a Role in Epithelial Patterning and in Neuronal Targeting.
Biochemical Biophysical Research Communications, 2001, 284(4), 1004-1010.

- Lopes, C., Rachidi, M., Charron, G., Chamoun, Z., Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B., Delezoide, A.L. and Delabar, JM. (2001). Conservation of the CNS expression pattern of new genes from the Down syndrome chromosomal region-1: human genes and their murine orthologs.
Cytogenetics and Cell Genetics, 2001, 92(1-2), 1-22.

- Rachidi, M., Lopes, C., Gassanova, S., Sinet, P.M., Vekemans, M., Attie, T., Delezoide, A.L. and Delabar, J.M. (2000). Regional and cellular specificity of TPRD, the tetratricopeptide Down Syndrome gene, during embryonic development.
Mechanisms of Development, 2000, 93(1-2), 189-193.

- Delabar, J.M., Rachidi, M., Lopes, C., Charron, G., Chamoun, Z, Dahmane, N., Toyama, K., Chettouh, Z., Vekemans, M., Bloch, B. and Delezoide, A.L. (2000). Conservation of the CNS expression pattern of new genes from the Down Syndrome Chromosomal Region-1: Human genes and their Murine orthologs.
European Journal Neuroscience, 2000, 12(Supp 11), 297.

- Orti, R., Rachidi, M., Viallard, F., Toyama, K., Lopes, C., Taudien, S., Rosenthal, A., Sinet, P.M. and Delabar, J.M. (2000). Characterisation of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and its murine ortholog.
Genomics, 2000, 64(2), 203-210.

- Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1999). Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues.
European Journal of Human Genetics, 1999, 7(Supp.1), 111.

- Rachidi, M., Lopes, C., Takamatsu, Y., Ohsako, S., Benichou J.C. and Delabar, J.M. (1999). Dynamic expression pattern of Ca2+/calmodulin-dependent protein kinase II gene in the central nervous system of Drosophila throughout development.
Biochemical Biophysical Research Communications, 1999, 260(3), 707-711.

- Lopes, C., Rachidi, M., Gassanova, S., Sinet, P.M. and Delabar, J.M. (1999). Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1.
Mechanisms of Development, 1999, 84(1-2), 189-193.

- Rahmani, Z., Lopes, C., Rachidi, M. and Delabar, J.M. (1998). Expression of the Mnb (dyrk) protein in adult and embryonic mouse tissues.
Biochemical Biophysical Research Communications,  1998, 253(2), 514-518.

- Rachidi, M., Lopes, C. and Benichou, J.C. (1997). Genetical analysis of visual system disorganizer (vid), a new gene involved in normal development of eye and optic lobe of the brain in Drosophila melanogaster. 
Genetica, 1997, 99, 31-45.

- Rachidi, M., Lopes, C., Benichou, J.C. and Rouyer, F. (1997). Analyse of period circadian expression in the Drosophila head by in situ hybridization. Journal of Neurogenetics, 1997, 11, 255-263.

- Rouyer, F., Rachidi, M., Pikielny, C. and Rosbash, M. (1997). A new gene encoding a putative transcritpion factor regulated by the Drosophila circadian clock.
EMBO Journal, 1997, 16(13), 3944-3954.

- Haoudi, A., Rachidi, M., Kim, M.H., Champion, S., Best-Belpomme, M. and Maisonhaute, C. (1997). Developmental expression analysis of the 1731 retrotransposon reveals an enhancement of Gag-Pol frameshifting in males of Drosophila melanogaster.
Gene, 1997, 196 (1-2), 83-93.

- Fassouane, A., Rachidi, M., Rouffaud, M.A., El-Abbouyi, A. and Nguyen, V.H. (1995). In vitro antifungal activity of Bacillus licheniformis FSJ-2 products against dermatophytes.
Journal of Mycology and Medicine, 1995, 5, 244-248.

- Rachidi, M. (1993). The Drosophila visual system: An elaborated building and a powerful model for developmental studies. Biomatec Journal, 1993, 4-5, 2-8.

Research Interest: Military toxicology; Acetylcholinesterase reactivators as treatment of nerve agent and pesticide intoxications; Acetylcholinesterase inhibitors in Alzheimer´s disease and Myasthenia Gravis treatment; Synthesis of the detergents as disinfectants, decontamination means and environment for micellar catalysis; Drug design and Development; Chemical warfare agents; Biological warfare agents; Pharmaceutical Industry; Project Management; Scientific Management; Technology Transfer; Commercialization; Fund Raising; Cloud computing; Parallel computing; medical devices development; toxins. 

Dr. Idress Hamad Attitalla, (Professor, 2015) has completed his PhD at the age of 31 years from Uppsala University (Sweden) and postdoctoral studies from USM University Sains Malaysia. I use to work as the director of Research and Study at Agriculture Research Center (ARC) up to 2014, also a Consultant and Director of European Branch at Libyan Commission for Education, Culture and Science. and Scientific Consultant, Libya and director of departments of microbiology at (Omar Al-Mukhtar University, Al-Bayda, Libyaوup to now), dean of Faculty of Mdecal Technology . He published more than 80 papers in reputed journals and serving as an editorial board member of repute, and 1 book in Arabic about Algae and 1 translated book about proteomic. I act as a Editor and Reviwers in many organization including Elsevier, with ORCID  0000-0002-1037-4837

Research Interest:

Microbiology; Molecular Biology and Biotechnology; Biosciences; Mycology and Bacteriology; Biomedical and Life Sciences; Agriculture and Forestry; Molecular Evolution.

List Of Publications:

1.    Idress H. Attitalla, S. Brishammar and S, Camyon. 1998. Effects of soil Moisture and Temperature on Incidence of Fusarium Wilt on Tomato. Journal of Mycology and Plant Pathology. 28: (3), 308-313. (ISI).

2.    Idress H. Attitalla, P. Quintanilla and S. Brishammar. 1998. Induced Resistance in Tomato Plants against Fusarium Wilt Invoked by Fusarium sp, Salicylic Acid and Phytophthora cryptogea. Acta Phytopathologica et Entomologica Hungarica. 33: (1-2), 89-95. (ISI).

3.    Idress H. Attitalla, P. Johnson, S. Brishammar and P. Quintanilla. 2001. Systemic Resistance to Fusarium Wilt in Tomato Induced by Phytophthora cryptogea. Journal of Phytopathology. 149, 373-380. (ISI, IF: 0.983).

4.    Idress. H. Attitalla, P. Maria Johansson, Sture Brishammar and Berndt Gerhardson. 2001. Pseudomonas sp. strain MF30 suppresses Fusarium wilt of tomato in vivo. Phyopathologia Mediterranea. 40, 234-239. (ISI, IF: 1.117).

5.    Idress H. Attitalla and S. Brishammar. 2002. Oxalic-Acid Elicited Resistance to Fusarium Wilt in Lycopersicon esculentum Mill. Plant Protection Science. 1, 128-131.

6.    Idress H. Attitalla, Jamshid Fatehi, Jens Levenfors and Sture Brishammar. 2004. A rapid molecular method for differentiating two special forms (lycopersici and radicis-lycopersici) of Fusarium oxysporum. Mycological Research. 108 (7): 787–794. (ISI, IF 2.92).

7.    Khaled, S. A., Faituri, M. Y., Idress H. Attitalla, El-Maraghy, S.S. M., and Issa, A.A. 2006. Physiology Responses of Wheat and Barley to Biofertilization. Assuit University Journal of Botany. 35 (2) 215–222. (ISI).

8.    Idress H. Attitalla, I.H. Bataw, A., Borowicz, J.J. and Brishammar, S. 2007. 16S rDNA analysis for characterization of Pseudomonas sp. strain MF30 isolated from Rumex acetoclla roots in northern Sweden. Arab Journal of Biotechnology. 10 (2): 97–106. (ISI).

9.    IdressAttitalla  et al. 2007. Adaptation of some plant communities in Xerophytes and Halophytes in East Libya. Al-Mukhtar Journal of Sciences.16: 96–81.

10.    Idress H. Attitalla, Laith K.T. Al-Ani, Muftah A. Nasib, Ibrahim A.A. Balal, Maziah Zakaria, Saad S.M. El-Maraghy and S.M. Rezaul Karim. 2010. Screening and identification of the associated fungi with commercial seeds and grains in El-Beida Governorate, Libya. World Applied Science Journal. 9 (7): 746–756. (ISI, Scopus). http://www.idosi.org/wasj/wasj9(7)/7.pdf

11.    Idress H. Attitalla, Latiffah Z. and Baharuddin Salleh. 2010. Biology and partial sequencing of an endophytic Fusarium oxysporum and plant defense complex. American Journal of Biochemistry and Molecular Biology. 1: 121-144 (Scopus) http://scialert.net/qredirect.php?doi=ajbmb.2011.121.144&linkid=pdf

12.    Idress H. Attitalla and Bahruddin Salleh. 2010. Improvement of Carboxymethyl cellulose, Xylanase production by alginate immobilized Trichoderma harzianum. Biotechnology. 9: 529-532 (ISI) http://scialert.net/qredirect.php?doi=biotech.2010.529.532&linkid=pdf

13.    Praveen Gehlot, Idress H. Attitalla and Baharuddin Salleh. 2010. Anamorphic Fungi: An Overview. Middle East Journal of Scientific Research. 6 (3): 201–208 (ISI) http://www.idosi.org/mejsr/mejsr6(3)/1.pdf

14.    Nagendra G. Babu, Phaninatha A. Sarma, Idress H. Attitalla and S.D.S. Murthy. 2010. Effect of Selected Heavy Metal Ions on the Photosynthetic Electron Transport and. Energy Transfer in the Thylakoid Membrane of the Cyanobacterium, Spirulina platensis. Academic Journal of Plant Sciences. 3 (1): 46-49. http://www.idosi.org/ajps/3(1)10/7.pdf

15.    Idress H. Attitalla , Abobaker M. Alhasin, Amir H. Ghazali, Latiffah Zakaria, Ibrahim A.A. Balal and Baharuddin Salleh. 2010. Occurrence and Microbiological Characteristics of Azospirillum Strains Associated with Leguminous and Non-Leguminous Plants in Al Jabal Al Akhdar Eco-region, Libya. American-Eurasian Journal of Agricultural and Environmental Sciences. 8 (6): 617-625.(ISI)
http://www.idosi.org/aejaes/jaes8(6)/1.pdf

16.    Balaji Meriga, Idress H. Attitalla, Mopuri Ramgopal, Anjaneyulu Ediga and P.B. Kavi. 2010. Differential Tolerance to Aluminium Toxicity in Rice Cultivars: Involvementof Antioxidative Enzymes and Possible Role of Aluminium Resistant Locus. Academic Journal of Plant Sciences. 3 (2): 53-63.

17.    Mopuri Ramgopal, Idress H. Attitalla, P.Avinash, and Meriga Balaji. 2010. Evaluation of Antilipidemic and Anti obesity efficacy of Bauhinia purpurea bark extract on Rats fed with high fat diet. Academic Journal of Plant Sciences. 3 (3): 104-107. http://www.idosi.org/ajps/3(3)10/1.pdf

18.    P. Peter, A. Phaninatha Sarma, Md Azeem ul Hasan, S.D.S. Murthy and Idress H. Attitalla. 2010. Studies on the Impact of Nitrogen Starvation on the Photosynthetic Pigments Through Spectral Proprties of Cyanobacterium, Spirulina platensis;: Identification of Target Phycobiliprotein under Nitrogen Chlorosis. Botany Research International. 3 (2): 38-42.

19.    E. Anjaneyulu, Idress H. Attitalla, S. Hemalatha, S. Bharath Raj and  M. Balaji. 2011. An Efficient Protocol for Callus Induction and Plant Regeneration in Finger Millet (Eleusine coracana L.). World Applied Science Journal. (ISI, Scopus), 12 (7): 919-923. http://www.idosi.org/wasj/wasj12(7)/2.pdf

20.    Ramgopal, Ch. Saisushma, Idress Hamad Attitalla, and Abobaker M. Alhasin. 2011. A Facile Green Synthesis of Silver Nanoparticles using Soap Nuts. Research Journal of Microbiology. (Scopus), 6 (5) 432-438. http://scialert.net/qredirect.php?doi=jm.2011.432.438&linkid=pdf

21.    Armaghan Shafaei, Elham Farsi, B.M. Khadeer Ahamed, M.J. Ahmad Siddiqui, Idress Hamad Attitalla and I. Zhari. 2011. Evaluation of Toxicological and Standardization Parameters and Phytochemical Investigation of Ficus deltoidea. American Journal of Biochemistry and Molecular Biology. 1 (3): 237-243, (Scopus).http://n0143855.servername.com/qredirect.php?doi=ajbmb.2011.237.243&linkid=pdf

22.    Avinash P, Idress H. Attitalla, Ramgopal M, Santhosh Ch, Balaji. 2011. M. In vitro antimicrobial and antioxidant activities of bark extracts of Bauhinia purpurea. 2011. African Journal of Biotechnology. 10 (45): 9160-9164 (ISI, IF: 0.565). http://www.academicjournals.org/AJB/PDF/pdf2011/17Aug/Avinash et al.pdf

23.    Idress H. Attitalla and Abobaker M. Alhasin 2012. Traits Biologically Interacting Azospirillum lipoferum Strain R23. Advances in Biological Research. 6 (2): 87-94, 2012.(PubMed).
http://www.idosi.org/abr/6(2)12/7.pdf

24.    Elham Farsi, Armaghan Shafaei, Sook Yee Hor, Mohamed B. Khadeer Ahamed, Mun Fei Yam, Idress Hamad Attitalla, Mohd. Z. Asmawi, and Zhari Ismail. 2011. Correlation between enzymes inhibitory and antioxidant activities of standardized fractions of methanolic extract obtained from Ficus deltoidea leaves. African Journal of Biotechnology. 10: (67): 15184-15194.  (ISI, IF: 0.565). http://www.academicjournals.org/AJB/PDF/pdf2011/31Oct/Farsi et al.pdf

25.    Evueh, A. G, Okhuoya, J. A. and Osemwegie, O., and Idress Hamad Attitalla. 2011. Evaluation Phylloplane Fungi as Biocontrol Agent of Corynespora Leaf Disease of Rubber (Hevea Brasiliensis Muell. ARG.). 2011. World Journal of Fungal and Plant Biology. 2 (1): 01-05.
http://www.idosi.org/wjfpb/wjfpb2(1)11/1.pdf

26.    Muhammed Sarwar, Idress H. Attitalla, Mohammad Abdollahi. 2011. A Review on the Recent Advances in Pharmacological Studies on Medicinal Plants; Animal Studies are Done but Clinical Studies Needs Completing. Asian Journal of Animal and Veterinary Advances. 6 (8): 867-883. (ISI, Scopus, Impact Factor 0.869) http://scialert.net/qredirect.php?doi=ajava.2011.867.883&linkid=pdf

27.    Idress H. Attitalla. 2011. Felicia muricata Leaf Extract May not Completely Safe for Oral Remedies. Asian Journal of Animal and Veterinary Advances. 6 (9): 884-885. (ISI, Scopus, Impact Factor 0.869) http://209.238.2.121/qredirect.php?doi=ajava.2011.884.885&linkid=pdf

28.    Idress H. Attitalla. 2011. Pharmacological Properties of Cassia nigricans Vahl Against Human and Veterinary Diseases. Asian Journal of Animal and Veterinary Advances. 6 (9): 886-887. (ISI, Scopus, Impact Factor 0.869).
http://scialert.net/qredirect.php?doi=ajava.2011.886.887&linkid=pdf

29.    Idress H. Attitalla. 2011. Motivational and Educational Campaings May Enhance the Attidue 0f Blood Donors Swiftly. Trends in Applied Sciences Research. 6 (11): 1238-1240. (ISI, Scopus) http://www.scialert.net/qredirect.php?doi=tasr.2011.1238.1240&linkid=pdf

30.    Muhammed Nouman Sohail, Fiaz Rasul, Asia Karim, Uzma Kanwal and Idress H. Attitalla. 2011. Plant as a Source of Natural Antiviral Agents. Asian Journal of Animal and Veterinary. 6 (12): 1125-1152. (ISI, Scopus, Impact Factor 0.869)
http://scialert.net/qredirect.php?doi=ajava.2011.1125.1152&linkid=pdf

31.    Idress H. Attitalla. 2011. Changes in the Iron Indices is Major Reason of Serum Hormone Disturbance in Thalassemia Patients. Journal of Medical Sciences. 11: 127-128. (ISI, Scopus)
http://scialert.net/qredirect.php?doi=jms.2011.127.128&linkid=pdf

32.    Idress H. Attitalla. 2011. Ocimum gratissimum as an Analgesic and Hepatoprotective Plant. Insight Ethnopharmacology. 1 (2): 9-10. (ISI) http://docsdrive.com/pdfs/insightknowledge/ETHNOPHARMA-IK/2011/9-10.pdf

33.    G.S. Panwar, Idress Hamad Attitalla and S.K. Guru. 2011. An Efficient in vitro Clonal Propagation and Estimation of Reserpine Content in Different Plant Parts of Rauwolfia serpentina L. American-Eurasian Journal of Agricultural and Environmental Sciences. 6 (4): 217-222.(ISI)
http://www.idosi.org/aejsr/6(4)11/7.pdf

34.    Idress H. Attitalla, Hanan M.A. El-Mesmary, Muftah A. Alhorer and Farj M. Shoaeb. 2009. Growth of the green alga Ankistrodesmus under various N/P ratios with spot light on the molecular taxonomy of its three species. Al-Mukhtar Journal of Sciences.24: 22-35.

35.    Idress H. Attitalla, Mikaeel Y. Faturi, Salleh A. Kahed and Faheem A. Bin Khayal and Bataw A. Fungal and Aflatoxin Contamination of Feed stuff Samples at El-Beida and Shahat Cities, Libya. (Accepted)-Sebha University Journal (Pure and Applied Sciences).

36.    Mikaeel Y. Faturi, M. Faraj M. Shoaeb., and Idress H. Attitalla. Tolerance of some Rhizobium leguminosae bv. vicia  to different salt concentrations. (Accepted)-Al-Mukhtar Journal of Sciences.

37.    Idress Hamad Attitalla.  2011. Anti-Colon Activity in Ethanolic Extract of Phytolacca americana. Pakistan Journal of Biological Sciences. 14: 914-915. (Review Article) (Scopus, ISI) http://scialert.net/qredirect.php?doi=pjbs.2011.914.915&linkid=pdf

38.    Idress Hamad Attitalla.  2011. Aloe barbadensis Provides Antiviral Defense to Tasar Silkworm. Pakistan Journal of Biological Sciences. 14: 958-959. (Review Article) (Scopus, ISI) http://scialert.net/qredirect.php?doi=pjbs.2011.958.959&linkid=pdf

39.    Idress Hamad Attitalla. 2011. Steroidal Ester of Cassia nigricans Have Antibacterial Potential. Pakistan Journal of Biological Sciences. 14: 996-997 (Review Article) (Scopus, ISI) http://docsdrive.com/pdfs/ansinet/pjbs/2011/996-997.pdfc

40.    Idress Hamad Attitalla. 2011. Effect of Croton penduliflorus on Intestinal Enzymes Activities. Pakistan Journal of Biological Sciences. 14: 1128-1129. (Review Article) (Scopus, ISI) http://scialert.net/qredirect.php?doi=pjbs.2011.1128.1129&linkid=pdf

41.    Idress Hamad Attitalla. 2011. Salvia verticillata Effects on Diabetes and Diabetes Complications. Pakistan Journal of Biological Sciences. 14: 1130-1131. (Review Article) (Scopus, ISI) http://scialert.net/qredirect.php?doi=pjbs.2011.1130.1131&linkid=pdf

42.    Idress Hamad Attitalla. 2011. PTU Induction Provide Quick Screening of Hypo and Hyperlipidemia. Pakistan Journal of Biological Sciences. 14: 1132-1133. (Review Article) (Scopus, ISI) http://scialert.net/qredirect.php?doi=pjbs.2011.1132.1133&linkid=pdf

43.    Idress Hamad Attitalla. 2011. A Wound Healer, Ampucare can Inhibits Bacterial Growth. Pakistan Journal of Biological Sciences. 14: 1126-1127. (Review Article) (Scopus, ISI) http://docsdrive.com/pdfs/ansinet/pjbs/2011/1126-1127.pdf

44.    Idress Hamad Attitalla. 2011. Lentinus sp. RJ-2 Mushroom is Important Source of Natural Antioxidative Polysaccharides. Pakistan Journal of Biological Sciences. 14: 1070-1071. (Review Article) (Scopus, ISI) http://scialert.net/qredirect.php?doi=pjbs.2011.1070.1071&linkid=pdf

45.    Idress Hamad Attitalla. 2011. Modified CTAB Method for High Quality Genomic DNA Extraction from Medicinal Plants. Pakistan Journal of Biological Sciences. 14: 998-999. (Review Article) (Scopus, ISI) http://scialert.net/qredirect.php?doi=pjbs.2011.998.999&linkid=pdf

46.    Idress Hamad Attitalla, Suliman S. Abdelrawaf, Khawila Saeed Omar, H.M.A. El-Komy and Muhammed Sarwar, 2012. Occurrence and Microbiological Characteristics of Trichoderma in Al-Jabal Al-Akhdar Region, Libya. Journal of Biological Sciences. 12: 209-217. (Scopus, ISI)http://scialert.net/qredirect.php?doi=jbs.2012.209.217&linkid=pdf
http://scialert.net/fulltext/?doi=jbs.2012.209.217&org=11#ab

47.    Idress Hamad Attitalla and Mehmet Ozaslan, 2012. DNA Based Diagnosis of Canine Bacterial Diseases. Journal of Animal and Veterinary Advances. 11: 1954-1964. (ISI, Scopus, Impact Factor 0.869)
http://docsdrive.com/pdfs/medwelljournals/javaa/2012/1954-1964.pdf

48.    Ahmed A. Issa, Idress H. Attitalla, Hanan M. A. El-Mesmary. 2012.  A first Report of Fresh Water Algae at Suluq lake, Libya. Topclass Journal of Microbiology.  1: (1) 018-024.

49.    Idress Hamad Attitalla. 2012. Wuling Capsule Can Improve Cognitive and Depression Defects of Stroke. Insight Ethnopharmacology. 2: 1-2.
http://docsdrive.com/pdfs/insightknowledge/ETHNOPHARMA-IK/2012/1-2.pdf

50.    El-Dougdoug, Kh.A., A.A. Megahed, B.A. Othman , S.M. Lashin, M.A. Ibrahim, and Idress Hamad Attitalla. 2012. Induction of Salicylic Acid in Cucumber Plants Against Cucumber mosaic cucumovirus Using Biotic Inducers. American Journal of Biochemistry and Molecular Biology. 3: 248-255 (Scopus)

51.    http://scialert.net/abstract/?doi=ajbmb.2013.248.255

52.    Ch.Santosh, Idress Hamad Attitalla, M.Madan Mohan. 2013. Phytochemical analysis, Antimicrobial and Antioxidant activity of Ethonolic extract of Vernonia anthelmintica. International Journal of Pharma and Bio Sciences. 4 (1): 960 - 966 (IF: 0.47) - http://www.ijpbs.net/archive-issue.php?issueid=21 (Number 96 in the list)

53.    Idress Hamad Attitalla. 2013. A Bacillus spp. A Probable Source of Thermophilic α-Amylaseproduction at Industrial Scale. Insight Bacteriology. 2 (1): 1-2.http://docsdrive.com/pdfs/insightknowledge/BACTERIOL-IK/2013/1-2.pdf

54.    Idress Hamad Attitalla. 2013. Lipid Related Genes Could Have a Link with the Regulation of Blood Pressure. Science International. 1: 1.
http://docsdrive.com/pdfs/scienceinternational/sciintl/2013/1-1.pdf

55.    Muhammad Nouman Sohail, S.M.N. Amin and Idress Hamad Attitalla. 2012. PCR Based Diagnosis of Fungal Diseases in Dogs. Journal of Animal and Veterinary Advances. 11: 2804-2812. (ISI, Scopus, Impact Factor 0.869)
http://docsdrive.com/pdfs/medwelljournals/javaa/2012/2804-2812.pdf

56.    Idress Hamad Attitalla and Mehmet Ozaslan. 2012. DNA Based Diagnosis of Canine Bacterial Diseases. Journal of Animal and Veterinary Advances. 11: 1954-1964. (ISI, Scopus, Impact Factor 0.869)http://docsdrive.com/pdfs/medwelljournals/javaa/2012/1954-1964.pdf

57.    Idress H. Attitalla. and Faituri, M. Y. Mass Loss and Nutrients Dynamics of Decomposing Aleppo Pine Brown Needle Litter Grown in Al-Jabel Al Akdar Ecoregion. (to be published).

58.    Mohamed Younes Abdelftah Hassan1, Omar Abdelateef Omar Saad, Magda Hassan Mahran, Ahmed Ismail Madkour, Suliman S Abdelrawaf and Idress Hamad Attitalla. 2013. A new medium for screening of gram negative bacteria in portable water. International Journal of Bioassays. 2: 379-381. (ISI, Scopus, Impact Factor 3.5).

59.    Idress Hamad Attitalla et al.. 2013. Prevalence of Trichoderma species in EL-Jabal EL-Akhdar region, Libya

60.    Idress Hamad Attitalla. 2013. Influence of Aspergillus flavus and A.terreus on the protein contents contaminated with Aflatoxins in Peanut Seeds at Al-Bayda Governorate, Libya. (to be published).

61.    Idress H. Attitalla. Some biochemical changes in Lycopersicon esculentum Mill. in response to inoculation with Phythopthora megasperma and its significance in induction of resistance against Fusarium wilt. . (to be published).

62.    Norlia Mahror, Idress H. Attitalla and Baharuddin Salleh. Screening and factors stimulate gibberellic acid production by Fusarium fujikuroi. (to be published).

63.    Idress H. Attitalla. Ibrahim A. A. Balal, Maziah Zakaria, Saad S.M. El-Maraghy. Detection of Aflatoxigenic fungi and Reduction of Aflatoxins in some Commercial Seeds and Grains in Al-Bayda Governorate, Libya. (to be published).

64.    Idress H. Attitalla. 2010. Molecular analysis of targeted FUM1 gene for the production of FB1 in Fusarium species associated with different host plants in Malaysia. (to be published).

65.    Norlia Mahror, Idress H. Attitalla and Baharuddin Salleh. Correlation between gibberellic acid production and pathogenic behavior of Fusarium fujikuroi that cause bakanae disease of rice. (to be published).

66.    Idress H. Attitalla, Saber E. Mansour, Laith K.T. Al-Ani, Aeshah M. Mohammed, Mikaeel Y. Faturi, Ibrahim A. A. Balal and Saad S.M. El-Maraghy. Influence of Aspergillus flavus and Aspergillus terreus in the protein value of the two varieties of peanut grains. (Poster at the International Mycotoxin Conference to be published - held at the Park Royal Hotel, Feringgi Beach, Penang Malaysia from 1st to 4th December 2010).

Research Interest: Business Economics, Knowledge Management, Cost Benefit Analysis Method – application in company and in medical device market development, Healthcare, efectivness of medical equipment development. 

Research Interest: Characterizing the mechanical properties and corrosion behaviour of biomaterials Mechanical surface treatments (shot peening and ball-burnishing) of metals and alloys. Coatings prior and after mechanical surface treatments. Evaluating the effects of Severe Plastic Deformations (SPD) on the materials. Characteristics Evaluation of surface layer properties (surface roughness, micro-hardness and residual stresses) of metals and alloys. Fatigue, corrosion fatigue and stress corrosion cracking of metals and alloys. Corrosion monitoring by electrochemical techniques. Analytical assessments by SEM and EDX. Analytical assessments by spectrophotometer and atomic absorption

Research Interest: Connective Tissue, Drugs Action, Microscopy, Protein Modeling, Bone Structure, Trace/major Elements, Image Processing, Electromagnetism, Spectroscopy, Biometrics, Human Networks

Research Interest: Since 2008 Paola Saccomandi has been involved in research activities in the fields of biomedical instrumentations and measurements applied to medicine. From 2008 to 2011 she worked under the supervisio of Prof. Sergio Silvestri and Dr. Emiliano Schena in the fied of mechanical ventilation. In particular she worked on development of optoelectronic and fiber optic-based flow sensors, as well as on ventilatory gases humidification. In 2011 she started her main research activity in the field of laser ablation of cancer, with particular regard to pancreatic tumor. She developed a mathematic model aiming to predic effects of laser light o pancreas, in terms of ablated volume and temperature distribution. Since 2012 she has been investigating the field of invasive (fiber optic sensors, thermocouples) and non-ivasive (based on diagnostic images) thermometry for temperature monitoring during laser ablation of tumour. In this activity she is actively collaborating with the team of research of the Institute for Diagnostic and Interventional Radiology of J. W. Goethe Universität Frankfurt am Main, headed by Prof. Thomas J. Vogl. Since 2013 she has been working in the fied of optical characterization of biological tissue, aiming to estimate optical properties of pancreas. She is collaborating with the team of Biophysics Institute J. W. Goethe Universität Frankfurt am Main, headed by Prof. Werner Mäntele. In the framework of laser ablation for the removal of pancreatic cancer, she has participated at the study approved by UCBM Ethics Committee -ComEt UCBM-, Prot. N. 4011/2011. The study aims to treat with laser ablation patients with inoperable pancreatic cancer. Since 2014 she is also involved in the design and development of tactile sensors for robotic artificial prosthetics

Research Interest: Scaffold Design For Tissue Engineering, Composites hydrogels For Bone Repair, Electrospinning and Electrospraying technology, Scanning and Trasmission Electron Microscopy, Image Analysis For Porosity Measurements, Chemical And Physical Properties Characterization Of Composite And/Or Polymeric Substrates, Injectable Composite Cements For Bone Cavity Filling.

Research Interest: Synthesis and characterization of inorganic and hybrid organic-inorganic nanomaterials, calcium phosphates, biomaterials, drug delivery, biomineralization and nanomedicine.

Research Interest: Stem cells and Regenerative Medicine, Tissue Regeneration, Tissue Engineering Stem Cells Biology and Differentiation, Stem cells biomaterials interaction, Mechanotransduction

Research Interest: Electromyography, muscle fatigue, motor units, innervation zone, anal sphincter, MMG, biofeedback, cervical kinematics, helical axis

Research Interest: Biophotonics and Biosensors

Research Interest: His current research interests include non-linear analysis of biomedical time series, specially the analysis of electroencephalographic and magnetoencephalographic recordings to help physicians in the diagnosis of brain disorders

Research Interest: Cell and tissue engineering

Research Interest: Shape memory materials and composites (bulk and thin film), Laser annealing and micro fabrication, Thin films (characterization and materials/devices) Micro/nano mechanics, nano patterning and indentation technology, Surface and optical properties of smart materials.  Advanced and novel materials.  Micro assembly and packaging, active disassembly. Deployable and bi-stable structures. Materials selection Flight mechanism in inserts Micro biomedical devices

Jin-Won Park received his B.S. degree from Korea University in 1998 and his M.S. and Ph.D. degrees from Purdue University, USA in 2003 and 2005, respectively. From 2007 to 2010, he was an assistant professor at the Gachon University, Korea. Since 2010, he has been a professor at Seoul National University of Science and Technology. His research interests are in biomimetic membranes and their applications.

Research Interests

Biophysics of Interfaces

The cell membrane, the interface between the cell and its environment, is the functional element in cellular metabolism and signaling. A great deal is found about the lipid, protein and saccharide constituents of membranes and their organization, and the physical properties are related with structures and functions.

A model has been utilized to study the physical properties of the cell membranes in which (glyco) proteins such as integrins, selectins, and lectins are involved in cellular interactions. On the other hand, direct measurements of the surface forces between lipid bilayers of phosphatidylethanolamine, phosphatidylcholoine, and galactolipids, the most common lipids in animal and plant membranes, suggest strong repulsive forces between highly hydrated head groups, which prevent membranes from coming into contact and reacting, adhering or fusing. Much could be known about the function and organization of the membrane's constituents if the physical properties of membranes could be measured with nano-meter scale lateral resolution.

Biosensing Platforms

Early detection of infectious diseases is important to enhance the quality of medical care and limit the spread of emerging infectious diseases. Thus, there is a need for rapid, sensitive, and inexpensive point-of-care sensors that have capability to identify multiple pathogens in complex samples such as blood.

Novel techniques have been developed for sensing pathogens, based on microfluidics. Eventually, the techniques will be platform for high throughput with low sample volume reagents and highly selective analyte sensing. These assays are designed to abstract molecular level details and mechanistic insights from biophysical and bioanalytical problems that would otherwise be difficult to approach.

Research Interest: Bone and cartilage disease modeling, drug screening and gene correctionDirect differentiation of pluripotent stem cells toward cartilage and boneBone reprogramming of fibroblasts using defined factors Gene therapy for cartilage regeneration and repair in regenerative medicine Signaling pathway of genes regulating cartilage differentiation of human mesenchymal stem cells.Molecular basis of mesenchymal stem cells maintaining their stemness. Stem cell biology and technique

Publications List:

1. Liu TM*, Yingnan Wu. Editorial: Advancing Gene and Cell Therapy using Human Mesenchymal Stem Cells. Front Cell Dev Biol, 2023, 11:1294460. doi: 10.3389/fcell.2023.1294460. eCollection 2023. (IF 6.081, *corresponding author). Published on 13 Oct 2023.
2. Yufeng Shou, Ling Liu, Zhicheng Le, Khang Leng Lee, Xianlei Li, DionZhanyun Koh, Yuwen Wang, Tong Ming Liu, Zheng Yang, Chwee Teck Lim, Christine Cheung, Andy Tay. Mechano-responsive hydrogel for directing stem cell manufacturing and therapy. Bioact Mater, 2023, 24:387-400. doi: 10.1016/j.bioactmat.2022.12.019. eCollection 2023 Jun. eCollection 2023 Jun. (IF 16.44). (2023 Jan 2)
3. Liu TM*. Application of mesenchymal stem cells derived from human pluripotent stem cells in regenerative medicine. World J Stem cells, 2021,13(12): 1826-1844. doi: 10.4252/wjsc.v13.i12.1826  (Invited review, IF 5.326, *corresponding author). (2021 Dec 26)
4. Srinivasan A, Sathiyanathan P, Yin L, Liu TM, Lam A, Ravikumar M, Smith RAA, Loh HP, Zhang Y, Ling L, Ng SK, Yang YS, Lezhava A, Hui J, Oh S, Cool SM. Strategies to Enhance Immunomodulatory Properties and Reduce Heterogeneity in Mesenchymal Stromal Cells during ex vivo Expansion. Cytotherapy (IF 5.414). 2022 May;24(5):456-472. doi: 10.1016/j.jcyt.2021.11.009. Epub 2022 Feb 25. PMID: 35227601
5. Liu TM*, Yildirim ED, Li P, Fang HT, Denslin V, Kumar V, Loh YH, Lee EH, Cool SM, Teh BT, Hui JH, Lim B, Shyh-Chang N. Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells.  Stem Cell Reports, 2020, 14:210-225 (IF 7.765, *corresponding author, cited 7). doi: 10.1016/j.stemcr.2020.01.002. Epub 2020 Jan 30. 11 February 2020.
6. Liu TM*. Regulation of chondrogenesis. Ann Stem Cell Res Ther. 2019; 3(1): 1028. (Invited Editorial, *corresponding author).
7. Liu TM, Shyh-Chang N. SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nat Cell Biol. 2017 Apr 27; 19(5):412-414. doi: 10.1038/ncb3522 (IF 20.06, cited 12).
8. Liu TM*. Stemness of Mesenchymal Stem Cells. J Stem Cell Ther Transplant. 2017; 1: 071-073 (Invited Editorial, *corresponding author, cited 9).
9. Cheng H, Ang HY, A El Farran C, Li P, Fang HT, Liu TM, Kong SL, Chin ML, Ling WY, Lim EK, Li H, Huber T, Loh KM, Loh YH, Lim B. Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors. Nat. Commun. 2016 Nov 21; 7:13396. doi: 10.1038/ncomms13396 (IF 11.3, cited 17).
10. Liu TM*, Lee EH, Lim B, Shyh-Chang N. Balancing Stem Cell Self-renewal and Differentiation with PLZF. Stem cells, 2016 Feb; 34(2):277-87. doi: 10.1002/stem.2270. Epub 2016 Jan 5 (IF 7.133, *corresponding author, cited 54).
11. Liu TM*. Stem Cell-Based Therapies for Cartilage Repair and Regeneration. J Stem Cells Res, Rev &. Rep. 2014, 1(1): 1-2 (Invited Editorial, *corresponding author).
12. Tan HK, Toh CX, Ma D, Yang B, Liu TM, Lu J, Wong CW, Tan TK, Li H, Syn C, Tan EL, Lim B, Lim YP, Cook SA, Loh YH. Human Finger-Prick Induced Pluripotent Stem Cells Facilitate the Development of Stem Cell Banking. Stem Cells Transl Med. 2014 May; 3(5):586-98. doi: 10.5966/sctm.2013-0195. Epub 2014 Mar 19. (IF 5.709, cited 42)
13. Liu TM*, Lee EH. Transcriptional regulatory cascades in Runx2-dependent bone development. Tissue Eng Part B Rev, 2013, 19(3):254-63. doi: 10.1089/ten.TEB.2012.0527. (*corresponding author). (IF 4.448, cited 238)
14. Liu TM*, Ng WM, Tan HS, Vinitha D, Yang Z, Fan JB, Zou Y, Hui JH, Lee EH, Lim B. Molecular basis of immortalization of human mesenchymal stem cells by combination of p53 knockdown and human telomerase reverse transcriptase overexpression. Stem Cells Dev. 2013 Jan 15; 22(2):268-78. doi: 10.1089/scd.2012.0222. Epub 2012 Aug 21. (IF4.67, *corresponding author, cited 67).
15. Liu TM*. Gene therapy for articular cartilage repair. Pharmaceutica Analytica Acta, 2012,3:e1112. doi:10.4172/2153-2435.1000e112 (Invited Editorial, *Corresponding author).
16. Yang Z, Zou Y, Guo XM, Tan HS, Denslin V, Yeow CH, Ren XF, Liu TM, Hui JH, Lee EH. Temporal activation of ß-catenin signaling in the chondrogenic process of mesenchymal stem cells affects the phenotype of the cartilage generated. Stem Cells Dev. 2012, 21:1966-1976. 2011 Dec 1. [Epub ahead of print]. (IF4.791, cited 35).
17. Liu TM^*, Guo XM, Tan HS, Hui JH, Lim B, Lee EH. Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair. Arthritis Rheum. 2011 Sep; 63(9):2711-20. doi: 10.1002/art.30430. (IF8.435, *Corresponding author, cited 72).
18. Liu T, Liu L, Wei Q, Hong Y. Sperm nuclear transfer and transgenic production in the fish medaka. Int J Biol Sci, 2011, 7(4): 469-475. (IF 3.215, cited 22)
19. Liu TM, Wu YN, Guo XM, Hui JH, Lee EH, Lim B. Effects of ectopic Nanog and Oct4 overexpression on mesenchymal stem cells. Stem Cells Dev. 2009 Sep;18(7):1013-22. doi: 10.1089/scd.2008.0335. (IF4.45, cited 164)
20. Liu TM, Martina M, Hutmacher DW, Hui JH, Lee EH, Lim B. Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells. 2007 Mar;25(3):750-60. doi: 10.1634/stemcells.2006-0394. Epub 2006 Nov 9. (IF 7.751, cited 524)
21. Lian Q, Lye E, Suan Yeo K, Khia Way Tan E, Salto-Tellez M, Liu TM, Palanisamy N, El Oakley RM, Lee EH, Lim B, Lim SK. Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs. Stem Cells. 2007 Feb; 25(2):425-36. doi: 10.1634/stemcells.2006-0420. Epub 2006 Oct 19. (IF 7.751, cited 298).
22. Y.H. Hong, T.M. Liu, H.B. Zhao, H.Y. Xu, W.J. Wang, R. Liu, T.S. Chen. Establishment of a normal medakafish spermatogonial cell line capable of sperm production in vitro. Proc. Natl. Acad. Sci. USA., 2004, 101(21): 8011-8016. (IF 10.3, cited 213)
23. Y.H. Hong, C. Winkler, T.M. Liu, G.X. Chai, M. Schartl. Activation of the mouse Oct4 promoter in medaka embryonic stem cells and its use for ablation of spontaneous differentiation. Mech. Dev., 2004, 121: 933-943. (IF 3.16, cited 61)
24. TM Liu, QJ Wu, YZ Ye. Studies on the artificial induce gynogenesia and the sex revesal in loach (Misgurnus anguillicaudatus). Acta Hydrobiologica Sinica, 2004, 28: 445-447 (cited 6).
25. TM Liu, XM Yu, YZ Ye, JF Zhou, ZW Wang, JG Tong, QJ Wu. 2002. Factors affecting the efficiency of somatic cell nuclear transplantation in the fish embryo. The Journal of Experimental Zoology, 2002, 293:719-725 (cited 20)
26. T. M. Liu, Q. J. Wu, X. M. Yu, X.Y. Li. Effects of cell-cycle arrest agents on cleavage and development of loach (Misgurnus anguillicaudatus) embryos. Fish Physiology and Biochemistry, 2002, 25:3-9.
27. TM Liu, XM Yu, YZ Ye, ZW Wang, JF Zhou, QJ Wu. Studies on factors affecting the development of embryos from somatic cell nuclear transplantation in the fish. Zoological Research, 2002, 23(2): 107-112.
28. YD Liu, LR Song, XY Li, TM Liu. The toxic effects of microcystin-LR on embry-larval and juvenile development of loach, Misgurnus Mizolipis Gunthe. Toxicon, 2002, 40(4): 395-399 (cited 137).
29. TM Liu and QJ Wu. 2000. Progress of nuclear transplantation in teleost.   Biotechnology Information, 6:24-28.
30. TM Liu, JW Cao, LY Wan, Y Liu, YX Yu. Subcloning of alkalophilic gene from alkalophilic Bacillus sp. NTT36 and its expression in Escherichia coli and Agrobacterium tumefaciens. Amino Acids & Biotic Resources, 1999, 21(2): 37-40.
31. LY Wang, JW Cao, TM Liu, XQ Zhang. Cloning and expression of promoter from an alkalophilic Bacillus sp. NTT89 in Escherichia coli. Journal of Wuhan University (Natural Science Edition), 2000, 46(2): 257-260.
32. Y Gong, JW Cao, TM Liu. Clone and subclone of the alkalophilic gene from alkalophilic Bacillus sp. NTT36 and analysis of expressed products in E.coli. Journal of Wuhan University (Natural Science Edition), 1998, 44(6): 775-780.

Research Interest: Protein engineering and protein chemistry, Nanobiotechnology and Protein nanocage, Biomaterials and Biomedical engineering, Industrial microbiology

Research Interest: Basic experiment skills in molecular and cell biology, immunology and zoology as follows: Molecular biology:Regular skills of molecular biology;plasmid construction, including shRNA and overexpression, GFP fusion protein, nucleic acid extraction, purification.  Biochemistry: protein expression analysis, including western blotting, immunoprecipitation and quantitative real-time RT-PCR; E.coli expressionsystem, soluble and insoluble protein purification.  Cell biology: Mammalian cell culture; plasmid transfection; development of stable transfected cell lines; immunohistochemistry; immunocytochemistry.   Others: Basic animal, especially mouse and rat handling skills;drosophila culture; familiar with ordinary operation of laser scanning confocal microscopy  (Leica,Zeiss,Olympus), fluorescence microscopy, fluorescence spectrometer;familiar with ordinary statistic and bioinformatical softwares.

Research Interest: Nano-Biomaterials Development, Cellular and Tissue Engineering Drug and Gene Delivery, Molecular Diagnostics Photobioreactor Design