Microwave Irradiated and Conventional Synthesis, Antibacterial Activity Evaluation Studies of Tryptamine-Azole-Fluoroquinolone Conjugates

Yıldız Uygun Cebeci1, Serap Basoglu Özdemir1, Ahmet Demirbas1, Neslihan Demirbas* and Sengül Alpay Karaoglu

Tryptamine was converted to the corresponding 1,2,4-triazole, 1,3,4-oxadiazole, 5-oxo-1,3-thia(oxa)zolidine and 5-(4-chlorophenyl)-1,3-thia(oxa)zole derivatives via several steps. 1,3,4-oxadiazole and 1,2,4-triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-components procedure. Conventional and microwave-assisted methods were applied for all syntheses. All the newly synthesized compounds were screened for their antibacterial and most of them were found to have good–moderate antibacterial activity.

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Published on: Dec 21, 2018 Pages: 10-20

Full Text PDF Full Text HTML DOI: 10.17352/abse.000009
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