Bacteriocin: A potent therapeutic weapon used as an alternative to antibiotics

Vidya Chauhan*

Bacteriocin has proved its potential as an alternative therapeutic molecule. The discovery of bacteriocin has been a miracle to combat Antibiotic Resistance including both multidrug-resistant and chronic bacterial infections. They are ribosomally synthesised Anti-Microbial Protein (AMP), produced by bacteria [1,2]. Many species of bacteria develop this antimicrobial defence for self-preservation and competitive advantage. In comparison to antibiotics bacteriocin are sensitive to proteases and being undisruptive for human consumption [3]. Bacteriocins are small cationic (30–60 amino acids), membrane-permeabilizing peptides produced by Gram-positive (small- 2-6kDa)/negative (large- >10kDa<20kDa) bacterial species. Bacteriocins of Gram-negative bacteria are usually released through cell lysis often dependent on SOS regulation. Gram-positive bacteria follow self-regulated and dedicated transport mechanisms to release bacteriocin. These bacteriocins have a varied spectrum of activity, mode of action and biochemical properties [4,5]. 

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Published on: Sep 14, 2020 Pages: 39-40

Full Text PDF Full Text HTML DOI: 10.17352/abse.000019
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